The Role of Crosstalk of Immune Cells in Pathogenesis of Chronic Spontaneous Urticaria
Chronic spontaneous urticaria (CSU) is defined as recurrent episodes of spontaneous wheal development and/or angioedema for more than six weeks and at least twice a week. The core link in the pathogenesis of CSU is the activation of mast cells, T cells, eosinophils, and other immune cells infiltrati...
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| Format: | Article |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.879754/full |
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| author | Bingjing Zhou Bingjing Zhou Bingjing Zhou Bingjing Zhou Jie Li Jie Li Jie Li Jie Li Runqiu Liu Runqiu Liu Runqiu Liu Runqiu Liu Lei Zhu Lei Zhu Lei Zhu Lei Zhu Cong Peng Cong Peng Cong Peng Cong Peng |
| author_facet | Bingjing Zhou Bingjing Zhou Bingjing Zhou Bingjing Zhou Jie Li Jie Li Jie Li Jie Li Runqiu Liu Runqiu Liu Runqiu Liu Runqiu Liu Lei Zhu Lei Zhu Lei Zhu Lei Zhu Cong Peng Cong Peng Cong Peng Cong Peng |
| author_sort | Bingjing Zhou |
| collection | DOAJ |
| description | Chronic spontaneous urticaria (CSU) is defined as recurrent episodes of spontaneous wheal development and/or angioedema for more than six weeks and at least twice a week. The core link in the pathogenesis of CSU is the activation of mast cells, T cells, eosinophils, and other immune cells infiltrating around the small venules of the lesion. Increased vascular permeability, vasodilatation, and recruitment of inflammatory cells directly depend on mast cell mediators’ release. Complex regulatory systems tightly influence the critical roles of mast cells in the local microenvironment. The bias toward Th2 inflammation and autoantibodies derived from B cells, histamine expressed by basophils, and initiation of the extrinsic coagulation pathway by eosinophils or monocytes exerts powerful modulatory influences on mast cells. Cell-to-cell interactions between mast cells and eosinophils/T cells also are regulators of their function and may involve CSU’s pathomechanism. This review summarizes up-to-date knowledge regarding the crosstalk between mast cells and other immune cells, providing the impetus to develop new research concepts and treatment strategies for CSU. |
| first_indexed | 2024-04-12T17:12:11Z |
| format | Article |
| id | doaj.art-913f8afb69ad4f5d98a243f0a4aed7a2 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T17:12:11Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-913f8afb69ad4f5d98a243f0a4aed7a22022-12-22T03:23:45ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-05-011310.3389/fimmu.2022.879754879754The Role of Crosstalk of Immune Cells in Pathogenesis of Chronic Spontaneous UrticariaBingjing Zhou0Bingjing Zhou1Bingjing Zhou2Bingjing Zhou3Jie Li4Jie Li5Jie Li6Jie Li7Runqiu Liu8Runqiu Liu9Runqiu Liu10Runqiu Liu11Lei Zhu12Lei Zhu13Lei Zhu14Lei Zhu15Cong Peng16Cong Peng17Cong Peng18Cong Peng19Department of Dermatology, Xiangya Hospital, Central South University, Changsha, ChinaNational Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, ChinaNational Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, ChinaNational Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, ChinaNational Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, ChinaNational Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaChronic spontaneous urticaria (CSU) is defined as recurrent episodes of spontaneous wheal development and/or angioedema for more than six weeks and at least twice a week. The core link in the pathogenesis of CSU is the activation of mast cells, T cells, eosinophils, and other immune cells infiltrating around the small venules of the lesion. Increased vascular permeability, vasodilatation, and recruitment of inflammatory cells directly depend on mast cell mediators’ release. Complex regulatory systems tightly influence the critical roles of mast cells in the local microenvironment. The bias toward Th2 inflammation and autoantibodies derived from B cells, histamine expressed by basophils, and initiation of the extrinsic coagulation pathway by eosinophils or monocytes exerts powerful modulatory influences on mast cells. Cell-to-cell interactions between mast cells and eosinophils/T cells also are regulators of their function and may involve CSU’s pathomechanism. This review summarizes up-to-date knowledge regarding the crosstalk between mast cells and other immune cells, providing the impetus to develop new research concepts and treatment strategies for CSU.https://www.frontiersin.org/articles/10.3389/fimmu.2022.879754/fullchronic spontaneous urticaria (CSU)mast cellsimmune cellscrosstalkpathogenesis |
| spellingShingle | Bingjing Zhou Bingjing Zhou Bingjing Zhou Bingjing Zhou Jie Li Jie Li Jie Li Jie Li Runqiu Liu Runqiu Liu Runqiu Liu Runqiu Liu Lei Zhu Lei Zhu Lei Zhu Lei Zhu Cong Peng Cong Peng Cong Peng Cong Peng The Role of Crosstalk of Immune Cells in Pathogenesis of Chronic Spontaneous Urticaria Frontiers in Immunology chronic spontaneous urticaria (CSU) mast cells immune cells crosstalk pathogenesis |
| title | The Role of Crosstalk of Immune Cells in Pathogenesis of Chronic Spontaneous Urticaria |
| title_full | The Role of Crosstalk of Immune Cells in Pathogenesis of Chronic Spontaneous Urticaria |
| title_fullStr | The Role of Crosstalk of Immune Cells in Pathogenesis of Chronic Spontaneous Urticaria |
| title_full_unstemmed | The Role of Crosstalk of Immune Cells in Pathogenesis of Chronic Spontaneous Urticaria |
| title_short | The Role of Crosstalk of Immune Cells in Pathogenesis of Chronic Spontaneous Urticaria |
| title_sort | role of crosstalk of immune cells in pathogenesis of chronic spontaneous urticaria |
| topic | chronic spontaneous urticaria (CSU) mast cells immune cells crosstalk pathogenesis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.879754/full |
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