Mitochondrial Dynamics and Liver Cancer
Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer. Due to its rising incidence and limited therapeutic options, HCC has become a leading cause of cancer-related death worldwide, accounting for 85% of all deaths due to primary liver cancers. Standard therapy for advanced-stage...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/11/2571 |
| _version_ | 1797532870282051584 |
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| author | María Isabel Hernández-Alvarez Antonio Zorzano |
| author_facet | María Isabel Hernández-Alvarez Antonio Zorzano |
| author_sort | María Isabel Hernández-Alvarez |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer. Due to its rising incidence and limited therapeutic options, HCC has become a leading cause of cancer-related death worldwide, accounting for 85% of all deaths due to primary liver cancers. Standard therapy for advanced-stage HCC is based on anti-angiogenic drugs such as sorafenib and, more recently, lenvatinib and regorafenib as a second line of treatment. The identification of novel therapeutic strategies is urgently required. Mitochondrial dynamics describes a group of processes that includes the movement of mitochondria along the cytoskeleton, the regulation of mitochondrial morphology and distribution, and connectivity mediated by tethering and fusion/fission events. In recent years, mitochondrial dynamic processes have emerged as key processes in the maintenance of liver mitochondrial homeostasis. In addition, some data are accumulating on the role played by mitochondrial dynamics during cancer development, and specifically on how such dynamics act directly on tumor cells or indirectly on cells responsible for tumor aggression and defense. Here, we review the data that suggest mitochondrial dynamics to be involved in the development of liver tumors. |
| first_indexed | 2024-03-10T11:06:30Z |
| format | Article |
| id | doaj.art-9140e53348a94d0597aa20f0c3cf9ac8 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T11:06:30Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-9140e53348a94d0597aa20f0c3cf9ac82023-11-21T21:07:59ZengMDPI AGCancers2072-66942021-05-011311257110.3390/cancers13112571Mitochondrial Dynamics and Liver CancerMaría Isabel Hernández-Alvarez0Antonio Zorzano1Departament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, SpainDepartament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, SpainHepatocellular carcinoma (HCC) is the most prevalent primary liver cancer. Due to its rising incidence and limited therapeutic options, HCC has become a leading cause of cancer-related death worldwide, accounting for 85% of all deaths due to primary liver cancers. Standard therapy for advanced-stage HCC is based on anti-angiogenic drugs such as sorafenib and, more recently, lenvatinib and regorafenib as a second line of treatment. The identification of novel therapeutic strategies is urgently required. Mitochondrial dynamics describes a group of processes that includes the movement of mitochondria along the cytoskeleton, the regulation of mitochondrial morphology and distribution, and connectivity mediated by tethering and fusion/fission events. In recent years, mitochondrial dynamic processes have emerged as key processes in the maintenance of liver mitochondrial homeostasis. In addition, some data are accumulating on the role played by mitochondrial dynamics during cancer development, and specifically on how such dynamics act directly on tumor cells or indirectly on cells responsible for tumor aggression and defense. Here, we review the data that suggest mitochondrial dynamics to be involved in the development of liver tumors.https://www.mdpi.com/2072-6694/13/11/2571hepatocellular carcinomachronic liver diseaseNASHliver fibrosisinsulin resistanceMitofusin 1 |
| spellingShingle | María Isabel Hernández-Alvarez Antonio Zorzano Mitochondrial Dynamics and Liver Cancer Cancers hepatocellular carcinoma chronic liver disease NASH liver fibrosis insulin resistance Mitofusin 1 |
| title | Mitochondrial Dynamics and Liver Cancer |
| title_full | Mitochondrial Dynamics and Liver Cancer |
| title_fullStr | Mitochondrial Dynamics and Liver Cancer |
| title_full_unstemmed | Mitochondrial Dynamics and Liver Cancer |
| title_short | Mitochondrial Dynamics and Liver Cancer |
| title_sort | mitochondrial dynamics and liver cancer |
| topic | hepatocellular carcinoma chronic liver disease NASH liver fibrosis insulin resistance Mitofusin 1 |
| url | https://www.mdpi.com/2072-6694/13/11/2571 |
| work_keys_str_mv | AT mariaisabelhernandezalvarez mitochondrialdynamicsandlivercancer AT antoniozorzano mitochondrialdynamicsandlivercancer |