Updates in the Language of <italic toggle="yes">Histoplasma</italic> Biodiversity
ABSTRACT In a recent article, Sepúlveda et al. (mBio 8:e01339-17, 2017, https://doi.org/10.1128/mBio.01339-17) investigated the genetic structure and evolutionary history of the human pathogen Histoplasma. Using whole-genome resequencing data, Sepúlveda et al. found that the Histoplasma genus is com...
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2018-07-01
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| Series: | mBio |
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| Online Access: | https://journals.asm.org/doi/10.1128/mBio.00181-18 |
| _version_ | 1818844429076660224 |
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| author | Pierre Gladieux |
| author_facet | Pierre Gladieux |
| author_sort | Pierre Gladieux |
| collection | DOAJ |
| description | ABSTRACT In a recent article, Sepúlveda et al. (mBio 8:e01339-17, 2017, https://doi.org/10.1128/mBio.01339-17) investigated the genetic structure and evolutionary history of the human pathogen Histoplasma. Using whole-genome resequencing data, Sepúlveda et al. found that the Histoplasma genus is composed of at least four strongly differentiated lineages. Their tour de force is to use a smart combination of population genomic approaches to show that the advanced stage of intraspecific divergence observed within Histoplasma does not simply reflect population structure, but instead results from previously unidentified speciation events. The four independently evolving Histoplasma lineages are elevated to the species status and assigned names. The newly described species exhibit medically important differences in phenotype, and these findings, therefore, have important epidemiological implications. This work provides a blueprint for phylogenomic species recognition in fungi, opening the way for a new age of enlightenment in which fungal species are diagnosed using highly discriminatory tools within a hypothesis-testing framework. |
| first_indexed | 2024-12-19T05:13:37Z |
| format | Article |
| id | doaj.art-9143757a557f45d6bfaa3951df1e0ec0 |
| institution | Directory Open Access Journal |
| issn | 2150-7511 |
| language | English |
| last_indexed | 2024-12-19T05:13:37Z |
| publishDate | 2018-07-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj.art-9143757a557f45d6bfaa3951df1e0ec02022-12-21T20:34:45ZengAmerican Society for MicrobiologymBio2150-75112018-07-019310.1128/mBio.00181-18Updates in the Language of <italic toggle="yes">Histoplasma</italic> BiodiversityPierre Gladieux0BGPI, Université de Montpellier, INRA, CIRAD, Montpellier SupAgro, Montpellier, FranceABSTRACT In a recent article, Sepúlveda et al. (mBio 8:e01339-17, 2017, https://doi.org/10.1128/mBio.01339-17) investigated the genetic structure and evolutionary history of the human pathogen Histoplasma. Using whole-genome resequencing data, Sepúlveda et al. found that the Histoplasma genus is composed of at least four strongly differentiated lineages. Their tour de force is to use a smart combination of population genomic approaches to show that the advanced stage of intraspecific divergence observed within Histoplasma does not simply reflect population structure, but instead results from previously unidentified speciation events. The four independently evolving Histoplasma lineages are elevated to the species status and assigned names. The newly described species exhibit medically important differences in phenotype, and these findings, therefore, have important epidemiological implications. This work provides a blueprint for phylogenomic species recognition in fungi, opening the way for a new age of enlightenment in which fungal species are diagnosed using highly discriminatory tools within a hypothesis-testing framework.https://journals.asm.org/doi/10.1128/mBio.00181-18fungigene flowgenomicspathogensspeciationsystematics |
| spellingShingle | Pierre Gladieux Updates in the Language of <italic toggle="yes">Histoplasma</italic> Biodiversity mBio fungi gene flow genomics pathogens speciation systematics |
| title | Updates in the Language of <italic toggle="yes">Histoplasma</italic> Biodiversity |
| title_full | Updates in the Language of <italic toggle="yes">Histoplasma</italic> Biodiversity |
| title_fullStr | Updates in the Language of <italic toggle="yes">Histoplasma</italic> Biodiversity |
| title_full_unstemmed | Updates in the Language of <italic toggle="yes">Histoplasma</italic> Biodiversity |
| title_short | Updates in the Language of <italic toggle="yes">Histoplasma</italic> Biodiversity |
| title_sort | updates in the language of italic toggle yes histoplasma italic biodiversity |
| topic | fungi gene flow genomics pathogens speciation systematics |
| url | https://journals.asm.org/doi/10.1128/mBio.00181-18 |
| work_keys_str_mv | AT pierregladieux updatesinthelanguageofitalictoggleyeshistoplasmaitalicbiodiversity |