Cardiovascular disease risk factors induce mesenchymal features and senescence in mouse cardiac endothelial cells

Cardiovascular disease risk factors induce mesenchymal features and senescence in mouse cardiac endothelial cells

Aging, obesity, hypertension, and physical inactivity are major risk factors for endothelial dysfunction and cardiovascular disease (CVD). We applied fluorescence-activated cell sorting (FACS), RNA sequencing, and bioinformatic methods to investigate the common effects of CVD risk factors in mouse c...

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Bibliographic Details
Main Authors: Karthik Amudhala Hemanthakumar, Shentong Fang, Andrey Anisimov, Mikko I Mäyränpää, Eero Mervaala, Riikka Kivelä
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-03-01
Series:eLife
Subjects:
aging
obesity
exercise
heart
endothelium
Online Access:https://elifesciences.org/articles/62678

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