Biosynthesis of Novel Ascorbic Acid Esters and Their Encapsulation in Lignin Nanoparticles as Carriers and Stabilizing Systems
A dual-target strategy was designed for the application of lignin nanoparticles in the lipase mediated biosynthesis of novel 3-<i>O</i>-ethyl-L-ascorbyl-6-ferulate and 3-<i>O</i>-ethyl-L-ascorbyl-6-palmitate and in their successive solvent-shift encapsulation in order to impr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/10/9044 |
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| author | Eliana Capecchi Davide Piccinino Chiara Nascimben Elisabetta Tomaino Natalia Ceccotti Vlas Sofia Gabellone Raffaele Saladino |
| author_facet | Eliana Capecchi Davide Piccinino Chiara Nascimben Elisabetta Tomaino Natalia Ceccotti Vlas Sofia Gabellone Raffaele Saladino |
| author_sort | Eliana Capecchi |
| collection | DOAJ |
| description | A dual-target strategy was designed for the application of lignin nanoparticles in the lipase mediated biosynthesis of novel 3-<i>O</i>-ethyl-L-ascorbyl-6-ferulate and 3-<i>O</i>-ethyl-L-ascorbyl-6-palmitate and in their successive solvent-shift encapsulation in order to improve stability and antioxidant activity against temperature and pH-dependent degradation. The loaded lignin nanoparticles were fully characterized in terms of kinetic release, radical scavenging activity and stability under pH 3 and thermal stress (60 °C), showing improved antioxidant activity and high efficacy in the protection of ascorbic acid esters from degradation. |
| first_indexed | 2024-03-11T03:38:40Z |
| format | Article |
| id | doaj.art-914614acc3fe4b9e87ecb6c648d0896d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T03:38:40Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-914614acc3fe4b9e87ecb6c648d0896d2023-11-18T01:46:26ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-05-012410904410.3390/ijms24109044Biosynthesis of Novel Ascorbic Acid Esters and Their Encapsulation in Lignin Nanoparticles as Carriers and Stabilizing SystemsEliana Capecchi0Davide Piccinino1Chiara Nascimben2Elisabetta Tomaino3Natalia Ceccotti Vlas4Sofia Gabellone5Raffaele Saladino6Department of Biological and Ecological Sciences (DEB), University of Tuscia, Via San Camillo de Lellis, 01100 Viterbo, ItalyDepartment of Biological and Ecological Sciences (DEB), University of Tuscia, Via San Camillo de Lellis, 01100 Viterbo, ItalyDepartment of Biological and Ecological Sciences (DEB), University of Tuscia, Via San Camillo de Lellis, 01100 Viterbo, ItalyDepartment of Biological and Ecological Sciences (DEB), University of Tuscia, Via San Camillo de Lellis, 01100 Viterbo, ItalyDepartment of Biological and Ecological Sciences (DEB), University of Tuscia, Via San Camillo de Lellis, 01100 Viterbo, ItalyIstituto Romagnolo per lo Studio dei Tumori “Dino Amadori”—IRST-IRCCS, Via Piero Maroncelli 40, 47014 Meldola, ItalyDepartment of Biological and Ecological Sciences (DEB), University of Tuscia, Via San Camillo de Lellis, 01100 Viterbo, ItalyA dual-target strategy was designed for the application of lignin nanoparticles in the lipase mediated biosynthesis of novel 3-<i>O</i>-ethyl-L-ascorbyl-6-ferulate and 3-<i>O</i>-ethyl-L-ascorbyl-6-palmitate and in their successive solvent-shift encapsulation in order to improve stability and antioxidant activity against temperature and pH-dependent degradation. The loaded lignin nanoparticles were fully characterized in terms of kinetic release, radical scavenging activity and stability under pH 3 and thermal stress (60 °C), showing improved antioxidant activity and high efficacy in the protection of ascorbic acid esters from degradation.https://www.mdpi.com/1422-0067/24/10/9044ascorbic acid esterslipaseheterogenous catalysisencapsulationlignin nanoparticles |
| spellingShingle | Eliana Capecchi Davide Piccinino Chiara Nascimben Elisabetta Tomaino Natalia Ceccotti Vlas Sofia Gabellone Raffaele Saladino Biosynthesis of Novel Ascorbic Acid Esters and Their Encapsulation in Lignin Nanoparticles as Carriers and Stabilizing Systems International Journal of Molecular Sciences ascorbic acid esters lipase heterogenous catalysis encapsulation lignin nanoparticles |
| title | Biosynthesis of Novel Ascorbic Acid Esters and Their Encapsulation in Lignin Nanoparticles as Carriers and Stabilizing Systems |
| title_full | Biosynthesis of Novel Ascorbic Acid Esters and Their Encapsulation in Lignin Nanoparticles as Carriers and Stabilizing Systems |
| title_fullStr | Biosynthesis of Novel Ascorbic Acid Esters and Their Encapsulation in Lignin Nanoparticles as Carriers and Stabilizing Systems |
| title_full_unstemmed | Biosynthesis of Novel Ascorbic Acid Esters and Their Encapsulation in Lignin Nanoparticles as Carriers and Stabilizing Systems |
| title_short | Biosynthesis of Novel Ascorbic Acid Esters and Their Encapsulation in Lignin Nanoparticles as Carriers and Stabilizing Systems |
| title_sort | biosynthesis of novel ascorbic acid esters and their encapsulation in lignin nanoparticles as carriers and stabilizing systems |
| topic | ascorbic acid esters lipase heterogenous catalysis encapsulation lignin nanoparticles |
| url | https://www.mdpi.com/1422-0067/24/10/9044 |
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