Synthesis, oligonucleotide incorporation and fluorescence properties in DNA of a bicyclic thymine analogue

Synthesis, oligonucleotide incorporation and fluorescence properties in DNA of a bicyclic thymine analogue

Abstract Fluorescent base analogues (FBAs) have emerged as a powerful class of molecular reporters of location and environment for nucleic acids. In our overall mission to develop bright and useful FBAs for all natural nucleobases, herein we describe the synthesis and thorough characterization of bi...

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Bibliographic Details
Main Authors: Christopher P. Lawson, Anders F. Füchtbauer, Moa S. Wranne, Tristan Giraud, Thomas Floyd, Blaise Dumat, Nicolai K. Andersen, Afaf H. El-Sagheer, Tom Brown, Henrik Gradén, L. Marcus Wilhelmsson, Morten Grøtli
Format: Article
Language:English
Published: Nature Portfolio 2018-09-01
Series:Scientific Reports
Subjects:
Thymine Analogue
Oligonucleotide Incorporation
Fluorescent Base Analogues (FBAs)
Natural Nucleobases
MeCN Water
Online Access:https://doi.org/10.1038/s41598-018-31897-2

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