Stepwise acquisition of unique epigenetic signatures during differentiation of tissue Treg cells
Regulatory T cells in non-lymphoid tissues are not only critical for maintaining self-tolerance, but are also important for promoting organ homeostasis and tissue repair. It is proposed that the generation of tissue Treg cells is a stepwise, multi-site process, accompanied by extensive epigenome rem...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1082055/full |
| _version_ | 1811178005953773568 |
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| author | Kathrin L. Braband Kathrin L. Braband Tamara Kaufmann Tamara Kaufmann Stefan Floess Mangge Zou Jochen Huehn Jochen Huehn Michael Delacher Michael Delacher |
| author_facet | Kathrin L. Braband Kathrin L. Braband Tamara Kaufmann Tamara Kaufmann Stefan Floess Mangge Zou Jochen Huehn Jochen Huehn Michael Delacher Michael Delacher |
| author_sort | Kathrin L. Braband |
| collection | DOAJ |
| description | Regulatory T cells in non-lymphoid tissues are not only critical for maintaining self-tolerance, but are also important for promoting organ homeostasis and tissue repair. It is proposed that the generation of tissue Treg cells is a stepwise, multi-site process, accompanied by extensive epigenome remodeling, finally leading to the acquisition of unique tissue-specific epigenetic signatures. This process is initiated in the thymus, where Treg cells acquire core phenotypic and functional properties, followed by a priming step in secondary lymphoid organs that permits Treg cells to exit the lymphoid organs and seed into non-lymphoid tissues. There, a final specialization process takes place in response to unique microenvironmental cues in the respective tissue. In this review, we will summarize recent findings on this multi-site tissue Treg cell differentiation and highlight the importance of epigenetic remodeling during these stepwise events. |
| first_indexed | 2024-04-11T06:12:08Z |
| format | Article |
| id | doaj.art-914b0a3aab7543979c780dd8986835e0 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T06:12:08Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-914b0a3aab7543979c780dd8986835e02022-12-22T04:41:14ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-12-011310.3389/fimmu.2022.10820551082055Stepwise acquisition of unique epigenetic signatures during differentiation of tissue Treg cellsKathrin L. Braband0Kathrin L. Braband1Tamara Kaufmann2Tamara Kaufmann3Stefan Floess4Mangge Zou5Jochen Huehn6Jochen Huehn7Michael Delacher8Michael Delacher9Institute for Immunology, University Medical Center Mainz, Mainz, GermanyResearch Center for Immunotherapy, University Medical Center Mainz, Mainz, GermanyInstitute for Immunology, University Medical Center Mainz, Mainz, GermanyResearch Center for Immunotherapy, University Medical Center Mainz, Mainz, GermanyDepartment of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, GermanyDepartment of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, GermanyDepartment of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, GermanyHannover Medical School, Hannover, GermanyInstitute for Immunology, University Medical Center Mainz, Mainz, GermanyResearch Center for Immunotherapy, University Medical Center Mainz, Mainz, GermanyRegulatory T cells in non-lymphoid tissues are not only critical for maintaining self-tolerance, but are also important for promoting organ homeostasis and tissue repair. It is proposed that the generation of tissue Treg cells is a stepwise, multi-site process, accompanied by extensive epigenome remodeling, finally leading to the acquisition of unique tissue-specific epigenetic signatures. This process is initiated in the thymus, where Treg cells acquire core phenotypic and functional properties, followed by a priming step in secondary lymphoid organs that permits Treg cells to exit the lymphoid organs and seed into non-lymphoid tissues. There, a final specialization process takes place in response to unique microenvironmental cues in the respective tissue. In this review, we will summarize recent findings on this multi-site tissue Treg cell differentiation and highlight the importance of epigenetic remodeling during these stepwise events.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1082055/fullTregtissueepigeneticsmethylationhomeostasis |
| spellingShingle | Kathrin L. Braband Kathrin L. Braband Tamara Kaufmann Tamara Kaufmann Stefan Floess Mangge Zou Jochen Huehn Jochen Huehn Michael Delacher Michael Delacher Stepwise acquisition of unique epigenetic signatures during differentiation of tissue Treg cells Frontiers in Immunology Treg tissue epigenetics methylation homeostasis |
| title | Stepwise acquisition of unique epigenetic signatures during differentiation of tissue Treg cells |
| title_full | Stepwise acquisition of unique epigenetic signatures during differentiation of tissue Treg cells |
| title_fullStr | Stepwise acquisition of unique epigenetic signatures during differentiation of tissue Treg cells |
| title_full_unstemmed | Stepwise acquisition of unique epigenetic signatures during differentiation of tissue Treg cells |
| title_short | Stepwise acquisition of unique epigenetic signatures during differentiation of tissue Treg cells |
| title_sort | stepwise acquisition of unique epigenetic signatures during differentiation of tissue treg cells |
| topic | Treg tissue epigenetics methylation homeostasis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1082055/full |
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