Comparison of partial nephrectomy and radical nephrectomy for cystic renal cell carcinoma: a SEER-based and retrospective study
Abstract Cystic renal cell carcinoma (cRCC) is uncommon and surgical indication remains controversial. We compared radical nephrectomy (RN) with partial nephrectomy (PN) in patients with cRCC using data from the Surveillance, Epidemiology and End Results (SEER) database and a retrospective cohort in...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-34950-x |
| _version_ | 1797822885653381120 |
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| author | Wenhao Lin Zhenggang Yang Ling Yan Jun Dai Chen Fang Yining Hao Danfeng Xu Jin Zhang Juping Zhao |
| author_facet | Wenhao Lin Zhenggang Yang Ling Yan Jun Dai Chen Fang Yining Hao Danfeng Xu Jin Zhang Juping Zhao |
| author_sort | Wenhao Lin |
| collection | DOAJ |
| description | Abstract Cystic renal cell carcinoma (cRCC) is uncommon and surgical indication remains controversial. We compared radical nephrectomy (RN) with partial nephrectomy (PN) in patients with cRCC using data from the Surveillance, Epidemiology and End Results (SEER) database and a retrospective cohort including 106 cRCC patients hospitalized in Ruijin and Renji Hospitals from 2013 to 2022. The baseline characteristics between RN and PN groups in both cohorts were adjusted by propensity score-matching (PSM). A total of 640 patients were included in the SEER cohort. Before PSM, PN group in the SEER cohort had a lower level of T stage (p < 0.001) and comprised more Caucasians (p < 0.001). After PSM, RN was associated with worse overall survival (p < 0.001) and cancer-specific survival (p = 0.006) in contrast to PN. In the Chinese cohort, 86 patients who underwent PN and 20 patients who underwent RN were finally included. The mean proportions of estimated glomerular filtration rate preserved after RN were worse than PN. Therefore, PN should be preferred in cRCC patients. |
| first_indexed | 2024-03-13T10:15:55Z |
| format | Article |
| id | doaj.art-914b4d81f7c0487c8827811726779da5 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-13T10:15:55Z |
| publishDate | 2023-05-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-914b4d81f7c0487c8827811726779da52023-05-21T11:15:24ZengNature PortfolioScientific Reports2045-23222023-05-011311710.1038/s41598-023-34950-xComparison of partial nephrectomy and radical nephrectomy for cystic renal cell carcinoma: a SEER-based and retrospective studyWenhao Lin0Zhenggang Yang1Ling Yan2Jun Dai3Chen Fang4Yining Hao5Danfeng Xu6Jin Zhang7Juping Zhao8Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Urology, Renji Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Urology, Renji Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineAbstract Cystic renal cell carcinoma (cRCC) is uncommon and surgical indication remains controversial. We compared radical nephrectomy (RN) with partial nephrectomy (PN) in patients with cRCC using data from the Surveillance, Epidemiology and End Results (SEER) database and a retrospective cohort including 106 cRCC patients hospitalized in Ruijin and Renji Hospitals from 2013 to 2022. The baseline characteristics between RN and PN groups in both cohorts were adjusted by propensity score-matching (PSM). A total of 640 patients were included in the SEER cohort. Before PSM, PN group in the SEER cohort had a lower level of T stage (p < 0.001) and comprised more Caucasians (p < 0.001). After PSM, RN was associated with worse overall survival (p < 0.001) and cancer-specific survival (p = 0.006) in contrast to PN. In the Chinese cohort, 86 patients who underwent PN and 20 patients who underwent RN were finally included. The mean proportions of estimated glomerular filtration rate preserved after RN were worse than PN. Therefore, PN should be preferred in cRCC patients.https://doi.org/10.1038/s41598-023-34950-x |
| spellingShingle | Wenhao Lin Zhenggang Yang Ling Yan Jun Dai Chen Fang Yining Hao Danfeng Xu Jin Zhang Juping Zhao Comparison of partial nephrectomy and radical nephrectomy for cystic renal cell carcinoma: a SEER-based and retrospective study Scientific Reports |
| title | Comparison of partial nephrectomy and radical nephrectomy for cystic renal cell carcinoma: a SEER-based and retrospective study |
| title_full | Comparison of partial nephrectomy and radical nephrectomy for cystic renal cell carcinoma: a SEER-based and retrospective study |
| title_fullStr | Comparison of partial nephrectomy and radical nephrectomy for cystic renal cell carcinoma: a SEER-based and retrospective study |
| title_full_unstemmed | Comparison of partial nephrectomy and radical nephrectomy for cystic renal cell carcinoma: a SEER-based and retrospective study |
| title_short | Comparison of partial nephrectomy and radical nephrectomy for cystic renal cell carcinoma: a SEER-based and retrospective study |
| title_sort | comparison of partial nephrectomy and radical nephrectomy for cystic renal cell carcinoma a seer based and retrospective study |
| url | https://doi.org/10.1038/s41598-023-34950-x |
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