Mechanisms of iron metabolism in Caenorhabditis elegans
Iron is involved in many biological processes essential for sustaining life. In excess, iron is toxic due to its ability to catalyze the formation of free radicals that damage macromolecules. Organisms have developed specialized mechanisms to tightly regulate iron uptake, storage and efflux. Ove...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-05-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00113/full |
| _version_ | 1819089549423280128 |
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| author | Elizabeth A Leibold Cole P Anderson |
| author_facet | Elizabeth A Leibold Cole P Anderson |
| author_sort | Elizabeth A Leibold |
| collection | DOAJ |
| description | Iron is involved in many biological processes essential for sustaining life. In excess, iron is toxic due to its ability to catalyze the formation of free radicals that damage macromolecules. Organisms have developed specialized mechanisms to tightly regulate iron uptake, storage and efflux. Over the past decades, vertebrate model organisms have led to the identification of key genes and pathways that regulate systemic and cellular iron metabolism. This review provides an overview of iron metabolism in the roundworm Caenorhabditis elegans and highlights recent studies on the role of hypoxia and insulin signaling in the regulation of iron metabolism. Given that iron, hypoxia and insulin signaling pathways are evolutionarily conserved, C. elegans provides a genetic model organism that promises to provide new insights into mechanisms regulating mammalian iron metabolism |
| first_indexed | 2024-12-21T22:09:42Z |
| format | Article |
| id | doaj.art-914e6de0caa24b9bab91d9ab4742a5a0 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-21T22:09:42Z |
| publishDate | 2014-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-914e6de0caa24b9bab91d9ab4742a5a02022-12-21T18:48:37ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122014-05-01510.3389/fphar.2014.0011390931Mechanisms of iron metabolism in Caenorhabditis elegansElizabeth A Leibold0Cole P Anderson1University of UtahUniversity of UtahIron is involved in many biological processes essential for sustaining life. In excess, iron is toxic due to its ability to catalyze the formation of free radicals that damage macromolecules. Organisms have developed specialized mechanisms to tightly regulate iron uptake, storage and efflux. Over the past decades, vertebrate model organisms have led to the identification of key genes and pathways that regulate systemic and cellular iron metabolism. This review provides an overview of iron metabolism in the roundworm Caenorhabditis elegans and highlights recent studies on the role of hypoxia and insulin signaling in the regulation of iron metabolism. Given that iron, hypoxia and insulin signaling pathways are evolutionarily conserved, C. elegans provides a genetic model organism that promises to provide new insights into mechanisms regulating mammalian iron metabolismhttp://journal.frontiersin.org/Journal/10.3389/fphar.2014.00113/fullIroniron deficiencyC.elegansferritinhypoxia-inducible factorinsulin signaling pathway |
| spellingShingle | Elizabeth A Leibold Cole P Anderson Mechanisms of iron metabolism in Caenorhabditis elegans Frontiers in Pharmacology Iron iron deficiency C.elegans ferritin hypoxia-inducible factor insulin signaling pathway |
| title | Mechanisms of iron metabolism in Caenorhabditis elegans |
| title_full | Mechanisms of iron metabolism in Caenorhabditis elegans |
| title_fullStr | Mechanisms of iron metabolism in Caenorhabditis elegans |
| title_full_unstemmed | Mechanisms of iron metabolism in Caenorhabditis elegans |
| title_short | Mechanisms of iron metabolism in Caenorhabditis elegans |
| title_sort | mechanisms of iron metabolism in caenorhabditis elegans |
| topic | Iron iron deficiency C.elegans ferritin hypoxia-inducible factor insulin signaling pathway |
| url | http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00113/full |
| work_keys_str_mv | AT elizabethaleibold mechanismsofironmetabolismincaenorhabditiselegans AT colepanderson mechanismsofironmetabolismincaenorhabditiselegans |