High phenylalanine concentrations induce demyelination and microglial activation in mouse cerebellar organotypic slices

High phenylalanine concentrations induce demyelination and microglial activation in mouse cerebellar organotypic slices

Phenylketonuria (PKU) is an inborn error of metabolism. Mutations in the enzyme phenylalanine hydroxylase (PAH)-encoding gene lead to a decreased metabolism of the amino acid phenylalanine (Phe). The deficiency in PAH increases Phe levels in blood and brain. Accumulation of Phe can lead to delayed d...

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Bibliographic Details
Main Authors: Orli Thau-Zuchman, Patrick N. Pallier, Paul J. M. Savelkoul, Almar A. M. Kuipers, J. Martin Verkuyl, Adina T. Michael-Titus
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Neuroscience
Subjects:
white matter
phenylketonuria
organotypic slices
phenylalanine
microglia
cerebellum
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.926023/full

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