High phenylalanine concentrations induce demyelination and microglial activation in mouse cerebellar organotypic slices
Phenylketonuria (PKU) is an inborn error of metabolism. Mutations in the enzyme phenylalanine hydroxylase (PAH)-encoding gene lead to a decreased metabolism of the amino acid phenylalanine (Phe). The deficiency in PAH increases Phe levels in blood and brain. Accumulation of Phe can lead to delayed d...
Main Authors: | Orli Thau-Zuchman, Patrick N. Pallier, Paul J. M. Savelkoul, Almar A. M. Kuipers, J. Martin Verkuyl, Adina T. Michael-Titus |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-09-01
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Series: | Frontiers in Neuroscience |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.926023/full |
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