Small RNA functions in carbon metabolism and virulence of enteric pathogens
Enteric pathogens often cycle between virulent and saprophytic lifestyles. To endure these frequent changes in nutrient availability and composition bacteria possess an arsenal of regulatory and metabolic genes allowing rapid adaptation and high flexibility. While numerous proteins have been charact...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-07-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fcimb.2014.00091/full |
| _version_ | 1828279033090015232 |
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| author | Kai ePapenfort Jörg eVogel |
| author_facet | Kai ePapenfort Jörg eVogel |
| author_sort | Kai ePapenfort |
| collection | DOAJ |
| description | Enteric pathogens often cycle between virulent and saprophytic lifestyles. To endure these frequent changes in nutrient availability and composition bacteria possess an arsenal of regulatory and metabolic genes allowing rapid adaptation and high flexibility. While numerous proteins have been characterized with regard to metabolic control in pathogenic bacteria, small non-coding RNAs have emerged as additional regulators of metabolism. Recent advances in sequencing technology have vastly increased the number of candidate regulatory RNAs and several of them have been found to act at the interface of bacterial metabolism and virulence factor expression. Importantly, studying these riboregulators has not only provided insight into their metabolic control functions but also revealed new mechanisms of post-transcriptional gene control. This review will focus on the recent advances in this area of host-microbe interaction and discuss how regulatory small RNAs may help coordinate metabolism and virulence of enteric pathogens. |
| first_indexed | 2024-04-13T07:38:10Z |
| format | Article |
| id | doaj.art-914f6b796c9e4f63a1ed1eaa5b1cb637 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-13T07:38:10Z |
| publishDate | 2014-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-914f6b796c9e4f63a1ed1eaa5b1cb6372022-12-22T02:56:01ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882014-07-01410.3389/fcimb.2014.0009197277Small RNA functions in carbon metabolism and virulence of enteric pathogensKai ePapenfort0Jörg eVogel1Princeton UniversityUniversity of WürzburgEnteric pathogens often cycle between virulent and saprophytic lifestyles. To endure these frequent changes in nutrient availability and composition bacteria possess an arsenal of regulatory and metabolic genes allowing rapid adaptation and high flexibility. While numerous proteins have been characterized with regard to metabolic control in pathogenic bacteria, small non-coding RNAs have emerged as additional regulators of metabolism. Recent advances in sequencing technology have vastly increased the number of candidate regulatory RNAs and several of them have been found to act at the interface of bacterial metabolism and virulence factor expression. Importantly, studying these riboregulators has not only provided insight into their metabolic control functions but also revealed new mechanisms of post-transcriptional gene control. This review will focus on the recent advances in this area of host-microbe interaction and discuss how regulatory small RNAs may help coordinate metabolism and virulence of enteric pathogens.http://journal.frontiersin.org/Journal/10.3389/fcimb.2014.00091/fullVirulenceHfqCarbon MetabolismCsrAsRNA |
| spellingShingle | Kai ePapenfort Jörg eVogel Small RNA functions in carbon metabolism and virulence of enteric pathogens Frontiers in Cellular and Infection Microbiology Virulence Hfq Carbon Metabolism CsrA sRNA |
| title | Small RNA functions in carbon metabolism and virulence of enteric pathogens |
| title_full | Small RNA functions in carbon metabolism and virulence of enteric pathogens |
| title_fullStr | Small RNA functions in carbon metabolism and virulence of enteric pathogens |
| title_full_unstemmed | Small RNA functions in carbon metabolism and virulence of enteric pathogens |
| title_short | Small RNA functions in carbon metabolism and virulence of enteric pathogens |
| title_sort | small rna functions in carbon metabolism and virulence of enteric pathogens |
| topic | Virulence Hfq Carbon Metabolism CsrA sRNA |
| url | http://journal.frontiersin.org/Journal/10.3389/fcimb.2014.00091/full |
| work_keys_str_mv | AT kaiepapenfort smallrnafunctionsincarbonmetabolismandvirulenceofentericpathogens AT jorgevogel smallrnafunctionsincarbonmetabolismandvirulenceofentericpathogens |