Opposing Effects of ApoE2 and ApoE4 on Glycolytic Metabolism in Neuronal Aging Supports a Warburg Neuroprotective Cascade against Alzheimer’s Disease

Opposing Effects of ApoE2 and ApoE4 on Glycolytic Metabolism in Neuronal Aging Supports a Warburg Neuroprotective Cascade against Alzheimer’s Disease

Apolipoprotein E4 (ApoE4) is the most recognized genetic risk factor for late-onset Alzheimer’s disease (LOAD), whereas ApoE2 reduces the risk for LOAD. The underlying mechanisms are unclear but may include effects on brain energy metabolism. Here, we used neuro-2a (N2a) cells that stably express hu...

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Bibliographic Details
Main Authors: Xin Zhang, Long Wu, Russell H. Swerdlow, Liqin Zhao
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cells
Subjects:
late-onset Alzheimer’s disease (LOAD)
apolipoprotein E
ApoE2
ApoE4
hexokinase
glycolysis
Online Access:https://www.mdpi.com/2073-4409/12/3/410

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