Whole genome typing of the recently emerged Canadian serogroup W Neisseria meningitidis sequence type 11 clonal complex isolates associated with invasive meningococcal disease
Objectives: This study was performed to analyze the Canadian invasive serogroup W Neisseria meningitidis (MenW) sequence type 11 (ST-11) clonal complex (CC) isolates by whole genome typing and to compare Canadian isolates with similar isolates from elsewhere. Methods: Whole genome typing of 30 MenW...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-04-01
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| Series: | International Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971218300201 |
| _version_ | 1819067192393596928 |
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| author | Raymond S.W. Tsang Tauqeer Ahmad Shaun Tyler Brigitte Lefebvre Shelley L. Deeks Rodica Gilca Linda Hoang Gregory Tyrrell Paul Van Caeseele Gary Van Domselaar Frances B. Jamieson |
| author_facet | Raymond S.W. Tsang Tauqeer Ahmad Shaun Tyler Brigitte Lefebvre Shelley L. Deeks Rodica Gilca Linda Hoang Gregory Tyrrell Paul Van Caeseele Gary Van Domselaar Frances B. Jamieson |
| author_sort | Raymond S.W. Tsang |
| collection | DOAJ |
| description | Objectives: This study was performed to analyze the Canadian invasive serogroup W Neisseria meningitidis (MenW) sequence type 11 (ST-11) clonal complex (CC) isolates by whole genome typing and to compare Canadian isolates with similar isolates from elsewhere. Methods: Whole genome typing of 30 MenW ST-11 CC, 20 meningococcal group C (MenC) ST-11 CC, and 31 MenW ST-22 CC isolates was performed on the Bacterial Isolate Genome Sequence database platform. Canadian MenW ST-11 CC isolates were compared with the 2000 MenW Hajj outbreak strain, as well as with MenW ST-11 CC from other countries. Results: Whole genome typing showed that the Canadian MenW ST-11 CC isolates were distinct from the traditional MenW ST-22 CC; they were not capsule-switched contemporary MenC strains that incorporated MenW capsules. While some recent MenW disease cases in Canada were caused by MenW ST-11 CC isolates showing relatedness to the 2000 MenW Hajj strain, many were non-Hajj isolates similar to current MenW ST-11 isolates found globally. Geographical and temporal variations in genotypes and surface protein antigen genes were found among the MenW ST-11 CC isolates. Conclusions: The current MenW ST-11 isolates did not arise by capsule switching from contemporary MenC ST-11 isolates. Both the Hajj-related and non-Hajj MenW ST-11 CC strains were associated with invasive meningococcal disease in Canada. Keywords: Neisseria meningitidis, Invasive meningococcal disease, Whole genome typing |
| first_indexed | 2024-12-21T16:14:21Z |
| format | Article |
| id | doaj.art-9151ceb7f93b4f2880dee20898c03d94 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-21T16:14:21Z |
| publishDate | 2018-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-9151ceb7f93b4f2880dee20898c03d942022-12-21T18:57:43ZengElsevierInternational Journal of Infectious Diseases1201-97122018-04-01695562Whole genome typing of the recently emerged Canadian serogroup W Neisseria meningitidis sequence type 11 clonal complex isolates associated with invasive meningococcal diseaseRaymond S.W. Tsang0Tauqeer Ahmad1Shaun Tyler2Brigitte Lefebvre3Shelley L. Deeks4Rodica Gilca5Linda Hoang6Gregory Tyrrell7Paul Van Caeseele8Gary Van Domselaar9Frances B. Jamieson10Vaccine Preventable Bacterial Diseases, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada; Corresponding author at: National Microbiology Laboratory, 1015 Arlington Street, Winnipeg, Manitoba R3E 3R2, Canada.Vaccine Preventable Bacterial Diseases, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, CanadaVaccine Preventable Bacterial Diseases, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, CanadaLaboratoire de Santé Publique du Québec, Institut National de Santé Publique du Québec, Ste-Anne-Bellevue, Québec, CanadaPublic Health Ontario, Toronto, Ontario, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, CanadaInstitut National de Santé Publique du Québec, Centre de Recherche du CHU-Université Laval, Québec, Canada; Department de Medecine Sociale et Preventive de l’Université Laval, Québec, CanadaBC Public Health Microbiology and Reference Laboratory, Vancouver, British Columbia, CanadaProvincial Laboratory for Public Health, Edmonton, Alberta, CanadaCadham Provincial Laboratory, Winnipeg, Manitoba, CanadaVaccine Preventable Bacterial Diseases, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, CanadaPublic Health Ontario, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, CanadaObjectives: This study was performed to analyze the Canadian invasive serogroup W Neisseria meningitidis (MenW) sequence type 11 (ST-11) clonal complex (CC) isolates by whole genome typing and to compare Canadian isolates with similar isolates from elsewhere. Methods: Whole genome typing of 30 MenW ST-11 CC, 20 meningococcal group C (MenC) ST-11 CC, and 31 MenW ST-22 CC isolates was performed on the Bacterial Isolate Genome Sequence database platform. Canadian MenW ST-11 CC isolates were compared with the 2000 MenW Hajj outbreak strain, as well as with MenW ST-11 CC from other countries. Results: Whole genome typing showed that the Canadian MenW ST-11 CC isolates were distinct from the traditional MenW ST-22 CC; they were not capsule-switched contemporary MenC strains that incorporated MenW capsules. While some recent MenW disease cases in Canada were caused by MenW ST-11 CC isolates showing relatedness to the 2000 MenW Hajj strain, many were non-Hajj isolates similar to current MenW ST-11 isolates found globally. Geographical and temporal variations in genotypes and surface protein antigen genes were found among the MenW ST-11 CC isolates. Conclusions: The current MenW ST-11 isolates did not arise by capsule switching from contemporary MenC ST-11 isolates. Both the Hajj-related and non-Hajj MenW ST-11 CC strains were associated with invasive meningococcal disease in Canada. Keywords: Neisseria meningitidis, Invasive meningococcal disease, Whole genome typinghttp://www.sciencedirect.com/science/article/pii/S1201971218300201 |
| spellingShingle | Raymond S.W. Tsang Tauqeer Ahmad Shaun Tyler Brigitte Lefebvre Shelley L. Deeks Rodica Gilca Linda Hoang Gregory Tyrrell Paul Van Caeseele Gary Van Domselaar Frances B. Jamieson Whole genome typing of the recently emerged Canadian serogroup W Neisseria meningitidis sequence type 11 clonal complex isolates associated with invasive meningococcal disease International Journal of Infectious Diseases |
| title | Whole genome typing of the recently emerged Canadian serogroup W Neisseria meningitidis sequence type 11 clonal complex isolates associated with invasive meningococcal disease |
| title_full | Whole genome typing of the recently emerged Canadian serogroup W Neisseria meningitidis sequence type 11 clonal complex isolates associated with invasive meningococcal disease |
| title_fullStr | Whole genome typing of the recently emerged Canadian serogroup W Neisseria meningitidis sequence type 11 clonal complex isolates associated with invasive meningococcal disease |
| title_full_unstemmed | Whole genome typing of the recently emerged Canadian serogroup W Neisseria meningitidis sequence type 11 clonal complex isolates associated with invasive meningococcal disease |
| title_short | Whole genome typing of the recently emerged Canadian serogroup W Neisseria meningitidis sequence type 11 clonal complex isolates associated with invasive meningococcal disease |
| title_sort | whole genome typing of the recently emerged canadian serogroup w neisseria meningitidis sequence type 11 clonal complex isolates associated with invasive meningococcal disease |
| url | http://www.sciencedirect.com/science/article/pii/S1201971218300201 |
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