Clinical utility of mesenchymal stem/stromal cells in regenerative medicine and cellular therapy
Abstract Mesenchymal stem/stromal cells (MSCs) have been carefully examined to have tremendous potential in regenerative medicine. With their immunomodulatory and regenerative properties, MSCs have numerous applications within the clinical sector. MSCs have the properties of multilineage differentia...
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | Journal of Biological Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13036-023-00361-9 |
| _version_ | 1797778844688580608 |
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| author | Vitali V. Maldonado Neel H. Patel Emma E. Smith C. Lowry Barnes Michael P. Gustafson Raj R. Rao Rebekah M. Samsonraj |
| author_facet | Vitali V. Maldonado Neel H. Patel Emma E. Smith C. Lowry Barnes Michael P. Gustafson Raj R. Rao Rebekah M. Samsonraj |
| author_sort | Vitali V. Maldonado |
| collection | DOAJ |
| description | Abstract Mesenchymal stem/stromal cells (MSCs) have been carefully examined to have tremendous potential in regenerative medicine. With their immunomodulatory and regenerative properties, MSCs have numerous applications within the clinical sector. MSCs have the properties of multilineage differentiation, paracrine signaling, and can be isolated from various tissues, which makes them a key candidate for applications in numerous organ systems. To accentuate the importance of MSC therapy for a range of clinical indications, this review highlights MSC-specific studies on the musculoskeletal, nervous, cardiovascular, and immune systems where most trials are reported. Furthermore, an updated list of the different types of MSCs used in clinical trials, as well as the key characteristics of each type of MSCs are included. Many of the studies mentioned revolve around the properties of MSC, such as exosome usage and MSC co-cultures with other cell types. It is worth noting that MSC clinical usage is not limited to these four systems, and MSCs continue to be tested to repair, regenerate, or modulate other diseased or injured organ systems. This review provides an updated compilation of MSCs in clinical trials that paves the way for improvement in the field of MSC therapy. |
| first_indexed | 2024-03-12T23:23:24Z |
| format | Article |
| id | doaj.art-91522a5e8e264204a0e3c535f236b046 |
| institution | Directory Open Access Journal |
| issn | 1754-1611 |
| language | English |
| last_indexed | 2024-03-12T23:23:24Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Biological Engineering |
| spelling | doaj.art-91522a5e8e264204a0e3c535f236b0462023-07-16T11:19:21ZengBMCJournal of Biological Engineering1754-16112023-07-0117112210.1186/s13036-023-00361-9Clinical utility of mesenchymal stem/stromal cells in regenerative medicine and cellular therapyVitali V. Maldonado0Neel H. Patel1Emma E. Smith2C. Lowry Barnes3Michael P. Gustafson4Raj R. Rao5Rebekah M. Samsonraj6Department of Biomedical Engineering, University of ArkansasDepartment of Biomedical Engineering, University of ArkansasDepartment of Biomedical Engineering, University of ArkansasDepartment of Orthopedic Surgery, University of Arkansas for Medical SciencesNyberg Human Cellular Therapy Laboratory, Mayo ClinicDepartment of Biomedical Engineering, University of ArkansasDepartment of Biomedical Engineering, University of ArkansasAbstract Mesenchymal stem/stromal cells (MSCs) have been carefully examined to have tremendous potential in regenerative medicine. With their immunomodulatory and regenerative properties, MSCs have numerous applications within the clinical sector. MSCs have the properties of multilineage differentiation, paracrine signaling, and can be isolated from various tissues, which makes them a key candidate for applications in numerous organ systems. To accentuate the importance of MSC therapy for a range of clinical indications, this review highlights MSC-specific studies on the musculoskeletal, nervous, cardiovascular, and immune systems where most trials are reported. Furthermore, an updated list of the different types of MSCs used in clinical trials, as well as the key characteristics of each type of MSCs are included. Many of the studies mentioned revolve around the properties of MSC, such as exosome usage and MSC co-cultures with other cell types. It is worth noting that MSC clinical usage is not limited to these four systems, and MSCs continue to be tested to repair, regenerate, or modulate other diseased or injured organ systems. This review provides an updated compilation of MSCs in clinical trials that paves the way for improvement in the field of MSC therapy.https://doi.org/10.1186/s13036-023-00361-9Mesenchymal stem/stromal cellsMSCsClinical trialsMusculoskeletalCardiovascularNervous system |
| spellingShingle | Vitali V. Maldonado Neel H. Patel Emma E. Smith C. Lowry Barnes Michael P. Gustafson Raj R. Rao Rebekah M. Samsonraj Clinical utility of mesenchymal stem/stromal cells in regenerative medicine and cellular therapy Journal of Biological Engineering Mesenchymal stem/stromal cells MSCs Clinical trials Musculoskeletal Cardiovascular Nervous system |
| title | Clinical utility of mesenchymal stem/stromal cells in regenerative medicine and cellular therapy |
| title_full | Clinical utility of mesenchymal stem/stromal cells in regenerative medicine and cellular therapy |
| title_fullStr | Clinical utility of mesenchymal stem/stromal cells in regenerative medicine and cellular therapy |
| title_full_unstemmed | Clinical utility of mesenchymal stem/stromal cells in regenerative medicine and cellular therapy |
| title_short | Clinical utility of mesenchymal stem/stromal cells in regenerative medicine and cellular therapy |
| title_sort | clinical utility of mesenchymal stem stromal cells in regenerative medicine and cellular therapy |
| topic | Mesenchymal stem/stromal cells MSCs Clinical trials Musculoskeletal Cardiovascular Nervous system |
| url | https://doi.org/10.1186/s13036-023-00361-9 |
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