Hyperoxia/Hypoxia Exposure Primes a Sustained Pro-Inflammatory Profile of Preterm Infant Macrophages Upon LPS Stimulation

Hyperoxia/Hypoxia Exposure Primes a Sustained Pro-Inflammatory Profile of Preterm Infant Macrophages Upon LPS Stimulation

Preterm infants are highly susceptible to sustained lung inflammation, which may be triggered by exposure to multiple environmental cues such as supplemental oxygen (O2) and infections. We hypothesized that dysregulated macrophage (MФ) activation is a key feature leading to inflammation-mediated dev...

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Bibliographic Details
Main Authors: Nele Twisselmann, Julia Pagel, Axel Künstner, Markus Weckmann, Annika Hartz, Kirsten Glaser, Anne Hilgendorff, Wolfgang Göpel, Hauke Busch, Egbert Herting, Jason B. Weinberg, Christoph Härtel
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
preterm infants
sustained inflammation
macrophages
hyperoxia
hypoxia
infection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.762789/full

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