Post Hoc Subgroup Analysis of the BCause Study Assessing the Effect of AbobotulinumtoxinA on Post-Stroke Shoulder Pain in Adults
Botulinum toxin type A is approved for the focal treatment of spasticity; however, the effectiveness of abobotulinumtoxinA (aboBoNT-A) in patients with shoulder pain who have set reduced pain as a treatment goal is understudied. In addition, some patients encounter delays in accessing treatment prog...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/14/11/809 |
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| author | Marcelo Riberto João Amaury Frances Regina Chueire Ana Cristina Ferreira Garcia Amorim Denise Xerez Tae Mo Chung Lucia Helena Costa Mercuri Sérgio Lianza Eduardo Carvalho de Melo Rocha Pascal Maisonobe Thais Cuperman-Pohl Patricia Khan |
| author_facet | Marcelo Riberto João Amaury Frances Regina Chueire Ana Cristina Ferreira Garcia Amorim Denise Xerez Tae Mo Chung Lucia Helena Costa Mercuri Sérgio Lianza Eduardo Carvalho de Melo Rocha Pascal Maisonobe Thais Cuperman-Pohl Patricia Khan |
| author_sort | Marcelo Riberto |
| collection | DOAJ |
| description | Botulinum toxin type A is approved for the focal treatment of spasticity; however, the effectiveness of abobotulinumtoxinA (aboBoNT-A) in patients with shoulder pain who have set reduced pain as a treatment goal is understudied. In addition, some patients encounter delays in accessing treatment programs; therefore, the suitability of aboBoNT-A for pain reduction in this population requires investigation. These factors were assessed in aboBoNT-A-naive Brazilian patients in a post hoc analysis of data from BCause, an observational, multicenter, prospective study (NCT02390206). Patients (N = 49, <i>n</i> = 25 female; mean (standard deviation) age of 60.3 (9.1) years; median (range) time since onset of spasticity of 16.1 (0–193) months) received aboBoNT-A injections to shoulder muscles in one or two treatment cycles (<i>n</i> = 47). Using goal attainment scaling (GAS), most patients achieved their goal of shoulder pain reduction after one treatment cycle (72.1%; 95% confidence interval: 57.2–83.4%). Improvements in GAS T-score from baseline, clinically meaningful reductions in pain score at movement, and clinically meaningful increases in passive shoulder abduction angle further improved with repeated treatment more than 4 months later, despite treatment starting at a median of 16.1 months after the onset of spasticity. These findings support the further investigation of aboBoNT-A injections in chronic post-stroke shoulder pain. |
| first_indexed | 2024-03-09T17:57:18Z |
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| id | doaj.art-9155f6becad2408bbfce9e82feba45de |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-09T17:57:18Z |
| publishDate | 2022-11-01 |
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| record_format | Article |
| series | Toxins |
| spelling | doaj.art-9155f6becad2408bbfce9e82feba45de2023-11-24T10:15:34ZengMDPI AGToxins2072-66512022-11-01141180910.3390/toxins14110809Post Hoc Subgroup Analysis of the BCause Study Assessing the Effect of AbobotulinumtoxinA on Post-Stroke Shoulder Pain in AdultsMarcelo Riberto0João Amaury Frances1Regina Chueire2Ana Cristina Ferreira Garcia Amorim3Denise Xerez4Tae Mo Chung5Lucia Helena Costa Mercuri6Sérgio Lianza7Eduardo Carvalho de Melo Rocha8Pascal Maisonobe9Thais Cuperman-Pohl10Patricia Khan11Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, São Paulo 14049-900, BrazilHospital Bettina Ferro de Souza, Campus IV da Universidade Federal do Pará, Belém 66075-110, BrazilFaculdade de Medicina de São José do Rio Preto, Autarquia Estadual 15090-000, BrazilCentro de Reabilitação e Readaptação Dr. Henrique Santillo (CRER), Goiânia 74653-230, BrazilServiço de Medicina Física e Reabilitação, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, BrazilComplexo Hospital das Clinicas, Instituto de Medicina Fisica e Reabilitação, São Paulo 04116-030, BrazilHospital São Paulo—UNIFESP, São Paulo 04024-002, BrazilHospital Alemão Oswaldo Cruz, São Paulo 01323-020, BrazilServiço de Reabilitação da Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo 01221-010, BrazilIpsen, 92100 Boulogne Billancourt, FranceIpsen, São Paulo 04571-010, BrazilCentro Catarinense de Reabilitação, Florianópolis, Santa Catarina 88025-301, BrazilBotulinum toxin type A is approved for the focal treatment of spasticity; however, the effectiveness of abobotulinumtoxinA (aboBoNT-A) in patients with shoulder pain who have set reduced pain as a treatment goal is understudied. In addition, some patients encounter delays in accessing treatment programs; therefore, the suitability of aboBoNT-A for pain reduction in this population requires investigation. These factors were assessed in aboBoNT-A-naive Brazilian patients in a post hoc analysis of data from BCause, an observational, multicenter, prospective study (NCT02390206). Patients (N = 49, <i>n</i> = 25 female; mean (standard deviation) age of 60.3 (9.1) years; median (range) time since onset of spasticity of 16.1 (0–193) months) received aboBoNT-A injections to shoulder muscles in one or two treatment cycles (<i>n</i> = 47). Using goal attainment scaling (GAS), most patients achieved their goal of shoulder pain reduction after one treatment cycle (72.1%; 95% confidence interval: 57.2–83.4%). Improvements in GAS T-score from baseline, clinically meaningful reductions in pain score at movement, and clinically meaningful increases in passive shoulder abduction angle further improved with repeated treatment more than 4 months later, despite treatment starting at a median of 16.1 months after the onset of spasticity. These findings support the further investigation of aboBoNT-A injections in chronic post-stroke shoulder pain.https://www.mdpi.com/2072-6651/14/11/809abobotulinumtoxinApatientspost-strokeshoulder painspasticitytherapeutic goal |
| spellingShingle | Marcelo Riberto João Amaury Frances Regina Chueire Ana Cristina Ferreira Garcia Amorim Denise Xerez Tae Mo Chung Lucia Helena Costa Mercuri Sérgio Lianza Eduardo Carvalho de Melo Rocha Pascal Maisonobe Thais Cuperman-Pohl Patricia Khan Post Hoc Subgroup Analysis of the BCause Study Assessing the Effect of AbobotulinumtoxinA on Post-Stroke Shoulder Pain in Adults Toxins abobotulinumtoxinA patients post-stroke shoulder pain spasticity therapeutic goal |
| title | Post Hoc Subgroup Analysis of the BCause Study Assessing the Effect of AbobotulinumtoxinA on Post-Stroke Shoulder Pain in Adults |
| title_full | Post Hoc Subgroup Analysis of the BCause Study Assessing the Effect of AbobotulinumtoxinA on Post-Stroke Shoulder Pain in Adults |
| title_fullStr | Post Hoc Subgroup Analysis of the BCause Study Assessing the Effect of AbobotulinumtoxinA on Post-Stroke Shoulder Pain in Adults |
| title_full_unstemmed | Post Hoc Subgroup Analysis of the BCause Study Assessing the Effect of AbobotulinumtoxinA on Post-Stroke Shoulder Pain in Adults |
| title_short | Post Hoc Subgroup Analysis of the BCause Study Assessing the Effect of AbobotulinumtoxinA on Post-Stroke Shoulder Pain in Adults |
| title_sort | post hoc subgroup analysis of the bcause study assessing the effect of abobotulinumtoxina on post stroke shoulder pain in adults |
| topic | abobotulinumtoxinA patients post-stroke shoulder pain spasticity therapeutic goal |
| url | https://www.mdpi.com/2072-6651/14/11/809 |
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