Does Metabolic Syndrome Affect the Incidence and Prognosis of Sudden Sensorineural Hearing Loss?
Earlier studies reported that the occurrence of sudden sensorineural hearing loss (SSNHL) is associated with chronic metabolic disorders such as hypertension, diabetes, and hyperlipidemia. Instead of focusing on the relationship between SSNHL and each metabolic disorder, this study aimed to identify...
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MDPI AG
2022-06-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/7/930 |
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| author | Joong Su Park Seung Ho Kim Ikhee Kim Hantai Kim Ji Hyun Kim Jong Bin Lee |
| author_facet | Joong Su Park Seung Ho Kim Ikhee Kim Hantai Kim Ji Hyun Kim Jong Bin Lee |
| author_sort | Joong Su Park |
| collection | DOAJ |
| description | Earlier studies reported that the occurrence of sudden sensorineural hearing loss (SSNHL) is associated with chronic metabolic disorders such as hypertension, diabetes, and hyperlipidemia. Instead of focusing on the relationship between SSNHL and each metabolic disorder, this study aimed to identify the association with metabolic syndrome as a whole, including either prehypertension or prediabetes. As a case-control study, we reviewed 239 patients who experienced SSNHL, and compared them with the same number of healthy subjects (<i>N</i> = 478). Metabolic syndrome-related variables of SSNHL patients were compared to those of healthy control subjects. In addition, patients with SSNHL were classified into two subgroups: the first subgroup showed improvement in hearing (‘response group’), and the second did not present significant improvement (‘non-response group’). Metabolic syndrome was diagnosed according to the US National Heart, Lung, and Blood Institute’s National Cholesterol Education Program Adult Treatment Panel III criteria. The risk for SSNHL was 4.3 times higher in patients with metabolic syndrome compared with patients without the syndrome (95% confidence interval, 1.98 to 9.33), even after adjusting for variables that showed significant between-group differences. The likelihood of being unresponsive to treatment was higher in those with metabolic syndrome (1.21 to 3.93; adjusted odds ratio = 2.18), and when the initial hearing loss pattern on a pure-tone audiometry was high tone or flat. Metabolic syndrome appears to be an independent risk factor for SSNHL and, simultaneously, a predictor of poor prognosis. |
| first_indexed | 2024-03-09T03:17:07Z |
| format | Article |
| id | doaj.art-9158446222894838824f38fd68f95b67 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T03:17:07Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-9158446222894838824f38fd68f95b672023-12-03T15:18:06ZengMDPI AGLife2075-17292022-06-0112793010.3390/life12070930Does Metabolic Syndrome Affect the Incidence and Prognosis of Sudden Sensorineural Hearing Loss?Joong Su Park0Seung Ho Kim1Ikhee Kim2Hantai Kim3Ji Hyun Kim4Jong Bin Lee5Department of Otorhinolaryngology-Head and Neck Surgery, Konyang University College of Medicine, Daejeon 35365, KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, Konyang University College of Medicine, Daejeon 35365, KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, Konyang University College of Medicine, Daejeon 35365, KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, Konyang University College of Medicine, Daejeon 35365, KoreaDepartment of Pediatrics, Dongguk University Hospital, Goyang 10326, KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, Konyang University College of Medicine, Daejeon 35365, KoreaEarlier studies reported that the occurrence of sudden sensorineural hearing loss (SSNHL) is associated with chronic metabolic disorders such as hypertension, diabetes, and hyperlipidemia. Instead of focusing on the relationship between SSNHL and each metabolic disorder, this study aimed to identify the association with metabolic syndrome as a whole, including either prehypertension or prediabetes. As a case-control study, we reviewed 239 patients who experienced SSNHL, and compared them with the same number of healthy subjects (<i>N</i> = 478). Metabolic syndrome-related variables of SSNHL patients were compared to those of healthy control subjects. In addition, patients with SSNHL were classified into two subgroups: the first subgroup showed improvement in hearing (‘response group’), and the second did not present significant improvement (‘non-response group’). Metabolic syndrome was diagnosed according to the US National Heart, Lung, and Blood Institute’s National Cholesterol Education Program Adult Treatment Panel III criteria. The risk for SSNHL was 4.3 times higher in patients with metabolic syndrome compared with patients without the syndrome (95% confidence interval, 1.98 to 9.33), even after adjusting for variables that showed significant between-group differences. The likelihood of being unresponsive to treatment was higher in those with metabolic syndrome (1.21 to 3.93; adjusted odds ratio = 2.18), and when the initial hearing loss pattern on a pure-tone audiometry was high tone or flat. Metabolic syndrome appears to be an independent risk factor for SSNHL and, simultaneously, a predictor of poor prognosis.https://www.mdpi.com/2075-1729/12/7/930metabolic syndromesudden sensorineural hearing lossmicrovascular injurycase-control study |
| spellingShingle | Joong Su Park Seung Ho Kim Ikhee Kim Hantai Kim Ji Hyun Kim Jong Bin Lee Does Metabolic Syndrome Affect the Incidence and Prognosis of Sudden Sensorineural Hearing Loss? Life metabolic syndrome sudden sensorineural hearing loss microvascular injury case-control study |
| title | Does Metabolic Syndrome Affect the Incidence and Prognosis of Sudden Sensorineural Hearing Loss? |
| title_full | Does Metabolic Syndrome Affect the Incidence and Prognosis of Sudden Sensorineural Hearing Loss? |
| title_fullStr | Does Metabolic Syndrome Affect the Incidence and Prognosis of Sudden Sensorineural Hearing Loss? |
| title_full_unstemmed | Does Metabolic Syndrome Affect the Incidence and Prognosis of Sudden Sensorineural Hearing Loss? |
| title_short | Does Metabolic Syndrome Affect the Incidence and Prognosis of Sudden Sensorineural Hearing Loss? |
| title_sort | does metabolic syndrome affect the incidence and prognosis of sudden sensorineural hearing loss |
| topic | metabolic syndrome sudden sensorineural hearing loss microvascular injury case-control study |
| url | https://www.mdpi.com/2075-1729/12/7/930 |
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