Interplay between integrins and cadherins to control bone differentiation upon BMP-2 stimulation

Interplay between integrins and cadherins to control bone differentiation upon BMP-2 stimulation

Introduction: Upon BMP-2 stimulation, the osteoblastic lineage commitment in C2C12 myoblasts is associated with a microenvironmental change that occurs over several days. How does BMP-2 operate a switch in adhesive machinery to adapt to the new microenvironment and to drive bone cell fate is not wel...

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Bibliographic Details
Main Authors: Anne Valat, Laure Fourel, Adria Sales, Paul Machillot, Anne-Pascale Bouin, Carole Fournier, Lauriane Bosc, Mélanie Arboléas, Ingrid Bourrin-Reynard, Amy J. Wagoner Johnson, Franz Bruckert, Corinne Albigès-Rizo, Catherine Picart
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
osteoblast differentation
BMP-2 (bone morphogenetic protein-2)
adhesion receptors
integrins
cadherins
extracellular matrix (ECM)
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.1027334/full

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