Polyvinyl Alcohol-Cellulose Nanocrystal Hydrogel Containing Anti-inflammatory Agent
Hydrogel wound dressings were developed through cross-linking reactions of polyvinyl alcohol (PVA) with glutaraldehyde and by the addition of diclofenac sodium and rutin as anti-inflammatory agents. Cellulose nanocrystals (CNC) were added to improve mechanically and release properties. CNC was isola...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Department of Chemistry, Universitas Gadjah Mada
2022-10-01
|
| Series: | Indonesian Journal of Chemistry |
| Subjects: | |
| Online Access: | https://jurnal.ugm.ac.id/ijc/article/view/73357 |
| _version_ | 1828103634126110720 |
|---|---|
| author | Lia Amelia Tresna Wulan Asri Athiya Anindya Yuni Eva Kartika Dita Puspitasari Untung Triadhi Husaini Ardy |
| author_facet | Lia Amelia Tresna Wulan Asri Athiya Anindya Yuni Eva Kartika Dita Puspitasari Untung Triadhi Husaini Ardy |
| author_sort | Lia Amelia Tresna Wulan Asri |
| collection | DOAJ |
| description | Hydrogel wound dressings were developed through cross-linking reactions of polyvinyl alcohol (PVA) with glutaraldehyde and by the addition of diclofenac sodium and rutin as anti-inflammatory agents. Cellulose nanocrystals (CNC) were added to improve mechanically and release properties. CNC was isolated from pineapple leaf fibers through the ammonium persulfate method resulting in a mixture of rod-like whisker and spherical morphology. The mechanical properties of hydrogels are increasing with the addition of CNC. Hydrogels containing 8% CNC exhibited 7.266 N/mm2 tensile strength, 156.3% maximum strain, and 700.3 N/mm2 elastic modulus. Drug release tests containing sodium diclofenac were done by taking incubated phosphate buffer saline samples in a pH 7.4 environment and showed that all CNC variations tested are controllable for the first 30 min compared to the sample without CNC. Sodium diclofenac is easily eluted from hydrogel due to its polar properties, and all samples almost demonstrated the same release profile. PVA hydrogels showed fluctuating concentrations of diclofenac compared to others. While hydrogels containing rutin showed a controlled release mode, the addition of CNC in PVA resulted in a slower release of rutin, possibly due to the better binding between CNC and rutin. To conclude, CNC has successfully improved the performance of PVA hydrogels, including the drug release properties. |
| first_indexed | 2024-04-11T09:28:05Z |
| format | Article |
| id | doaj.art-915c19da290541998957764a3ecfe148 |
| institution | Directory Open Access Journal |
| issn | 1411-9420 2460-1578 |
| language | English |
| last_indexed | 2024-04-11T09:28:05Z |
| publishDate | 2022-10-01 |
| publisher | Department of Chemistry, Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Chemistry |
| spelling | doaj.art-915c19da290541998957764a3ecfe1482022-12-22T04:31:58ZengDepartment of Chemistry, Universitas Gadjah MadaIndonesian Journal of Chemistry1411-94202460-15782022-10-012251293130310.22146/ijc.7335732538Polyvinyl Alcohol-Cellulose Nanocrystal Hydrogel Containing Anti-inflammatory AgentLia Amelia Tresna Wulan Asri0Athiya Anindya1Yuni Eva Kartika2Dita Puspitasari3Untung Triadhi4Husaini Ardy5Materials Science and Engineering Research Group, Faculty of Mechanical and Aerospace Engineering, Institut Teknologi Bandung, Jl. Ganesha No. 10, Bandung 40132, IndonesiaMaterials Science and Engineering Research Group, Faculty of Mechanical and Aerospace Engineering, Institut Teknologi Bandung, Jl. Ganesha No. 10, Bandung 40132, IndonesiaMaterials Science and Engineering Research Group, Faculty of Mechanical and Aerospace Engineering, Institut Teknologi Bandung, Jl. Ganesha No. 10, Bandung 40132, IndonesiaMaterials Science and Engineering Research Group, Faculty of Mechanical and Aerospace Engineering, Institut Teknologi Bandung, Jl. Ganesha No. 10, Bandung 40132, IndonesiaAnalytical Chemistry Division, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jl. Ganesha No. 10, Bandung 40132, IndonesiaMaterials Science and Engineering Research Group, Faculty of Mechanical and Aerospace Engineering, Institut Teknologi Bandung, Jl. Ganesha No. 10, Bandung 40132, IndonesiaHydrogel wound dressings were developed through cross-linking reactions of polyvinyl alcohol (PVA) with glutaraldehyde and by the addition of diclofenac sodium and rutin as anti-inflammatory agents. Cellulose nanocrystals (CNC) were added to improve mechanically and release properties. CNC was isolated from pineapple leaf fibers through the ammonium persulfate method resulting in a mixture of rod-like whisker and spherical morphology. The mechanical properties of hydrogels are increasing with the addition of CNC. Hydrogels containing 8% CNC exhibited 7.266 N/mm2 tensile strength, 156.3% maximum strain, and 700.3 N/mm2 elastic modulus. Drug release tests containing sodium diclofenac were done by taking incubated phosphate buffer saline samples in a pH 7.4 environment and showed that all CNC variations tested are controllable for the first 30 min compared to the sample without CNC. Sodium diclofenac is easily eluted from hydrogel due to its polar properties, and all samples almost demonstrated the same release profile. PVA hydrogels showed fluctuating concentrations of diclofenac compared to others. While hydrogels containing rutin showed a controlled release mode, the addition of CNC in PVA resulted in a slower release of rutin, possibly due to the better binding between CNC and rutin. To conclude, CNC has successfully improved the performance of PVA hydrogels, including the drug release properties.https://jurnal.ugm.ac.id/ijc/article/view/73357hydrogelwound dressingpolyvinyl alcoholcellulose nanocrystalsanti-inflammatory agents |
| spellingShingle | Lia Amelia Tresna Wulan Asri Athiya Anindya Yuni Eva Kartika Dita Puspitasari Untung Triadhi Husaini Ardy Polyvinyl Alcohol-Cellulose Nanocrystal Hydrogel Containing Anti-inflammatory Agent Indonesian Journal of Chemistry hydrogel wound dressing polyvinyl alcohol cellulose nanocrystals anti-inflammatory agents |
| title | Polyvinyl Alcohol-Cellulose Nanocrystal Hydrogel Containing Anti-inflammatory Agent |
| title_full | Polyvinyl Alcohol-Cellulose Nanocrystal Hydrogel Containing Anti-inflammatory Agent |
| title_fullStr | Polyvinyl Alcohol-Cellulose Nanocrystal Hydrogel Containing Anti-inflammatory Agent |
| title_full_unstemmed | Polyvinyl Alcohol-Cellulose Nanocrystal Hydrogel Containing Anti-inflammatory Agent |
| title_short | Polyvinyl Alcohol-Cellulose Nanocrystal Hydrogel Containing Anti-inflammatory Agent |
| title_sort | polyvinyl alcohol cellulose nanocrystal hydrogel containing anti inflammatory agent |
| topic | hydrogel wound dressing polyvinyl alcohol cellulose nanocrystals anti-inflammatory agents |
| url | https://jurnal.ugm.ac.id/ijc/article/view/73357 |
| work_keys_str_mv | AT liaameliatresnawulanasri polyvinylalcoholcellulosenanocrystalhydrogelcontainingantiinflammatoryagent AT athiyaanindya polyvinylalcoholcellulosenanocrystalhydrogelcontainingantiinflammatoryagent AT yunievakartika polyvinylalcoholcellulosenanocrystalhydrogelcontainingantiinflammatoryagent AT ditapuspitasari polyvinylalcoholcellulosenanocrystalhydrogelcontainingantiinflammatoryagent AT untungtriadhi polyvinylalcoholcellulosenanocrystalhydrogelcontainingantiinflammatoryagent AT husainiardy polyvinylalcoholcellulosenanocrystalhydrogelcontainingantiinflammatoryagent |