Dietary magnesium supplementation improves lifespan in a mouse model of progeria
Abstract Aging is associated with redox imbalance according to the redox theory of aging. Consistently, a mouse model of premature aging (LmnaG609G/+) showed an increased level of mitochondrial reactive oxygen species (ROS) and a reduced basal antioxidant capacity, including loss of the NADPH‐couple...
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| Format: | Article |
| Language: | English |
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Springer Nature
2020-10-01
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| Series: | EMBO Molecular Medicine |
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| Online Access: | https://doi.org/10.15252/emmm.202012423 |
| _version_ | 1797283611022458880 |
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| author | Ricardo Villa‐Bellosta |
| author_facet | Ricardo Villa‐Bellosta |
| author_sort | Ricardo Villa‐Bellosta |
| collection | DOAJ |
| description | Abstract Aging is associated with redox imbalance according to the redox theory of aging. Consistently, a mouse model of premature aging (LmnaG609G/+) showed an increased level of mitochondrial reactive oxygen species (ROS) and a reduced basal antioxidant capacity, including loss of the NADPH‐coupled glutathione redox system. LmnaG609G/+ mice also exhibited reduced mitochondrial ATP synthesis secondary to ROS‐induced mitochondrial dysfunction. Treatment of LmnaG609G/+ vascular smooth muscle cells with magnesium‐enriched medium improved the intracellular ATP level, enhanced the antioxidant capacity, and thereby reduced mitochondrial ROS production. Moreover, treatment of LmnaG609G/+ mice with dietary magnesium improved the proton pumps (complexes I, III, and IV), stimulated extramitochondrial NADH oxidation and enhanced the coupled mitochondrial membrane potential, and thereby increased H+‐coupled mitochondrial NADPH and ATP synthesis, which is necessary for cellular energy supply and survival. Consistently, magnesium treatment reduced calcification of vascular smooth muscle cells in vitro and in vivo, and improved the longevity of mice. This antioxidant property of magnesium may be beneficial in children with HGPS. |
| first_indexed | 2024-03-07T17:34:16Z |
| format | Article |
| id | doaj.art-916114f4fae9467d9b497838bf64f8d0 |
| institution | Directory Open Access Journal |
| issn | 1757-4676 1757-4684 |
| language | English |
| last_indexed | 2024-03-07T17:34:16Z |
| publishDate | 2020-10-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj.art-916114f4fae9467d9b497838bf64f8d02024-03-02T17:15:55ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842020-10-011210n/an/a10.15252/emmm.202012423Dietary magnesium supplementation improves lifespan in a mouse model of progeriaRicardo Villa‐Bellosta0Fundación Instituto de Investigación Sanitaria Fundación Jiménez Díaz Universidad Autónoma de Madrid Madrid SpainAbstract Aging is associated with redox imbalance according to the redox theory of aging. Consistently, a mouse model of premature aging (LmnaG609G/+) showed an increased level of mitochondrial reactive oxygen species (ROS) and a reduced basal antioxidant capacity, including loss of the NADPH‐coupled glutathione redox system. LmnaG609G/+ mice also exhibited reduced mitochondrial ATP synthesis secondary to ROS‐induced mitochondrial dysfunction. Treatment of LmnaG609G/+ vascular smooth muscle cells with magnesium‐enriched medium improved the intracellular ATP level, enhanced the antioxidant capacity, and thereby reduced mitochondrial ROS production. Moreover, treatment of LmnaG609G/+ mice with dietary magnesium improved the proton pumps (complexes I, III, and IV), stimulated extramitochondrial NADH oxidation and enhanced the coupled mitochondrial membrane potential, and thereby increased H+‐coupled mitochondrial NADPH and ATP synthesis, which is necessary for cellular energy supply and survival. Consistently, magnesium treatment reduced calcification of vascular smooth muscle cells in vitro and in vivo, and improved the longevity of mice. This antioxidant property of magnesium may be beneficial in children with HGPS.https://doi.org/10.15252/emmm.202012423agingHGPSmagnesiumprogeriavascular calcification |
| spellingShingle | Ricardo Villa‐Bellosta Dietary magnesium supplementation improves lifespan in a mouse model of progeria EMBO Molecular Medicine aging HGPS magnesium progeria vascular calcification |
| title | Dietary magnesium supplementation improves lifespan in a mouse model of progeria |
| title_full | Dietary magnesium supplementation improves lifespan in a mouse model of progeria |
| title_fullStr | Dietary magnesium supplementation improves lifespan in a mouse model of progeria |
| title_full_unstemmed | Dietary magnesium supplementation improves lifespan in a mouse model of progeria |
| title_short | Dietary magnesium supplementation improves lifespan in a mouse model of progeria |
| title_sort | dietary magnesium supplementation improves lifespan in a mouse model of progeria |
| topic | aging HGPS magnesium progeria vascular calcification |
| url | https://doi.org/10.15252/emmm.202012423 |
| work_keys_str_mv | AT ricardovillabellosta dietarymagnesiumsupplementationimproveslifespaninamousemodelofprogeria |