Successful eradication of chronic myeloid leukemia in a child despite allogeneic graft rejection
Abstract Background Chronic myeloid leukemia (CML) is a rare disease in children and treated with tyrosine kinase inhibitors (TKI) and with allogeneic hematopoietic stem cell transplantation (HSCT) still in many cases. Case We describe an 8‐year‐old patient with CML treated with two different TKIs b...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-10-01
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| Series: | Cancer Reports |
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| Online Access: | https://doi.org/10.1002/cnr2.1663 |
| _version_ | 1817985095376568320 |
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| author | Susanna Vuorenoja Kim Vettenranta Olli Lohi |
| author_facet | Susanna Vuorenoja Kim Vettenranta Olli Lohi |
| author_sort | Susanna Vuorenoja |
| collection | DOAJ |
| description | Abstract Background Chronic myeloid leukemia (CML) is a rare disease in children and treated with tyrosine kinase inhibitors (TKI) and with allogeneic hematopoietic stem cell transplantation (HSCT) still in many cases. Case We describe an 8‐year‐old patient with CML treated with two different TKIs before proceeding to allogeneic HSCT. Despite successful engraftment, prompt rejection of the graft was followed by autologous reconstitution. TKI therapy was reintroduced post‐rejection in anticipation of relapse but shortly discontinued due to low white blood cell and neutrophil counts. The patient has remained disease‐free over 5 years after graft rejection and without further therapy. Conclusion This case suggests that even a short antileukemic effect by an allogeneic transplant may succeed in eradicating CML. |
| first_indexed | 2024-04-13T23:52:44Z |
| format | Article |
| id | doaj.art-916455e956a14ace9fbde8dba274b303 |
| institution | Directory Open Access Journal |
| issn | 2573-8348 |
| language | English |
| last_indexed | 2024-04-13T23:52:44Z |
| publishDate | 2022-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj.art-916455e956a14ace9fbde8dba274b3032022-12-22T02:24:01ZengWileyCancer Reports2573-83482022-10-01510n/an/a10.1002/cnr2.1663Successful eradication of chronic myeloid leukemia in a child despite allogeneic graft rejectionSusanna Vuorenoja0Kim Vettenranta1Olli Lohi2Tampere Center for Child, Adolescent and Maternal Health Research, Tays Cancer Centre Tampere University Hospital, Tampere University Tampere FinlandPediatric Research Center, University of Helsinki Helsinki University Central Hospital, University of Helsinki Helsinki FinlandTampere Center for Child, Adolescent and Maternal Health Research, Tays Cancer Centre Tampere University Hospital, Tampere University Tampere FinlandAbstract Background Chronic myeloid leukemia (CML) is a rare disease in children and treated with tyrosine kinase inhibitors (TKI) and with allogeneic hematopoietic stem cell transplantation (HSCT) still in many cases. Case We describe an 8‐year‐old patient with CML treated with two different TKIs before proceeding to allogeneic HSCT. Despite successful engraftment, prompt rejection of the graft was followed by autologous reconstitution. TKI therapy was reintroduced post‐rejection in anticipation of relapse but shortly discontinued due to low white blood cell and neutrophil counts. The patient has remained disease‐free over 5 years after graft rejection and without further therapy. Conclusion This case suggests that even a short antileukemic effect by an allogeneic transplant may succeed in eradicating CML.https://doi.org/10.1002/cnr2.1663CMLeradicationgraft rejectionHSCTreconstitution |
| spellingShingle | Susanna Vuorenoja Kim Vettenranta Olli Lohi Successful eradication of chronic myeloid leukemia in a child despite allogeneic graft rejection Cancer Reports CML eradication graft rejection HSCT reconstitution |
| title | Successful eradication of chronic myeloid leukemia in a child despite allogeneic graft rejection |
| title_full | Successful eradication of chronic myeloid leukemia in a child despite allogeneic graft rejection |
| title_fullStr | Successful eradication of chronic myeloid leukemia in a child despite allogeneic graft rejection |
| title_full_unstemmed | Successful eradication of chronic myeloid leukemia in a child despite allogeneic graft rejection |
| title_short | Successful eradication of chronic myeloid leukemia in a child despite allogeneic graft rejection |
| title_sort | successful eradication of chronic myeloid leukemia in a child despite allogeneic graft rejection |
| topic | CML eradication graft rejection HSCT reconstitution |
| url | https://doi.org/10.1002/cnr2.1663 |
| work_keys_str_mv | AT susannavuorenoja successfuleradicationofchronicmyeloidleukemiainachilddespiteallogeneicgraftrejection AT kimvettenranta successfuleradicationofchronicmyeloidleukemiainachilddespiteallogeneicgraftrejection AT ollilohi successfuleradicationofchronicmyeloidleukemiainachilddespiteallogeneicgraftrejection |