The dual facilitatory and inhibitory effects of social pain on physical pain perception
Summary: Pain is a multi-dimensional phenomenon that encompasses both physical pain experienced physiologically and social pain experienced emotionally. The interactions between them are thought to lead to increased pain load. However, the effect of social pain on physical pain perception during int...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S258900422400172X |
| _version_ | 1797339159858249728 |
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| author | Ming Zhang Xiaomin Lin Yongkang Zhi Yan Mu Yazhuo Kong |
| author_facet | Ming Zhang Xiaomin Lin Yongkang Zhi Yan Mu Yazhuo Kong |
| author_sort | Ming Zhang |
| collection | DOAJ |
| description | Summary: Pain is a multi-dimensional phenomenon that encompasses both physical pain experienced physiologically and social pain experienced emotionally. The interactions between them are thought to lead to increased pain load. However, the effect of social pain on physical pain perception during interactions remains unclear. Four experiments were conducted merging physical and social pains to examine the behavioral pattern and neural mechanism of the effect of social pain on physical pain perception. Seemingly paradoxical effects of social pain were observed, which both facilitated and inhibited physical pain perception under different attention orientations. Brain imaging revealed that the posterior insula encoded the facilitatory effect, whereas the frontal pole engaged in the inhibitory effect. At a higher level, the thalamus further modulated both processes, playing a switch-like role under different concern statuses of social pain. These results provide direct evidence for the dual-pathway mechanism of the effect of social pain on physical pain. |
| first_indexed | 2024-03-08T09:41:55Z |
| format | Article |
| id | doaj.art-9165b060a1f74aaaa30b3bec3c795d02 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-08T09:41:55Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-9165b060a1f74aaaa30b3bec3c795d022024-01-30T04:17:15ZengElsevieriScience2589-00422024-02-01272108951The dual facilitatory and inhibitory effects of social pain on physical pain perceptionMing Zhang0Xiaomin Lin1Yongkang Zhi2Yan Mu3Yazhuo Kong4CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, ChinaCAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, ChinaCAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, ChinaCAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, ChinaCAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China; Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK; Corresponding authorSummary: Pain is a multi-dimensional phenomenon that encompasses both physical pain experienced physiologically and social pain experienced emotionally. The interactions between them are thought to lead to increased pain load. However, the effect of social pain on physical pain perception during interactions remains unclear. Four experiments were conducted merging physical and social pains to examine the behavioral pattern and neural mechanism of the effect of social pain on physical pain perception. Seemingly paradoxical effects of social pain were observed, which both facilitated and inhibited physical pain perception under different attention orientations. Brain imaging revealed that the posterior insula encoded the facilitatory effect, whereas the frontal pole engaged in the inhibitory effect. At a higher level, the thalamus further modulated both processes, playing a switch-like role under different concern statuses of social pain. These results provide direct evidence for the dual-pathway mechanism of the effect of social pain on physical pain.http://www.sciencedirect.com/science/article/pii/S258900422400172XHealth sciencesBiological sciencesNeuroscience |
| spellingShingle | Ming Zhang Xiaomin Lin Yongkang Zhi Yan Mu Yazhuo Kong The dual facilitatory and inhibitory effects of social pain on physical pain perception iScience Health sciences Biological sciences Neuroscience |
| title | The dual facilitatory and inhibitory effects of social pain on physical pain perception |
| title_full | The dual facilitatory and inhibitory effects of social pain on physical pain perception |
| title_fullStr | The dual facilitatory and inhibitory effects of social pain on physical pain perception |
| title_full_unstemmed | The dual facilitatory and inhibitory effects of social pain on physical pain perception |
| title_short | The dual facilitatory and inhibitory effects of social pain on physical pain perception |
| title_sort | dual facilitatory and inhibitory effects of social pain on physical pain perception |
| topic | Health sciences Biological sciences Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S258900422400172X |
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