In vitro-obtained meropenem-vaborbactam resistance mechanisms among clinical Klebsiella pneumoniae carbapenemase-producing K. pneumoniae isolates

In vitro-obtained meropenem-vaborbactam resistance mechanisms among clinical Klebsiella pneumoniae carbapenemase-producing K. pneumoniae isolates

ABSTRACT: Objectives: A novel ß-lactam-β-lactamase inhibitor (BLBI), meropenem (MEM), combined with the boronate-based inhibitor vaborbactam (VAB), has recently been introduced for the treatment of infections caused by Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacterales. The purpos...

Full description

Bibliographic Details
Main Authors:	Jacqueline Findlay, Laurent Poirel, Patrice Nordmann
Format:	Article
Language:	English
Published:	Elsevier 2023-03-01
Series:	Journal of Global Antimicrobial Resistance
Subjects:	Klebsiella pneumoniae Meropenem-vaborbactam KPC Carbapenemase Antibiotic resistance
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213716523000012

Similar Items

Overview of meropenem-vaborbactam and newer antimicrobial agents for the treatment of carbapenem-resistant Enterobacteriaceae
by: Petty LA, et al.
Published: (2018-09-01)

A Post-Neurosurgical Infection due to KPC-Producing Klebsiella pneumoniae Treated with Meropenem-Vaborbactam: A Case Report
by: Seohyun Choi, et al.
Published: (2022-09-01)

Ceftazidime/avibactam-resistant meropenem-susceptible KPC-producing Klebsiella pneumoniae: Analysis of cases and evaluation of in vitro activity of fosfomycin-containing combinations
by: A. Oliva, et al.
Published: (2023-06-01)

Screening for Klebsiella pneumoniae producing carbapenemase in Prato, Italy
by: Tamara Brunelli, et al.
Published: (2014-06-01)

Review of In Vitro Efficacy of Ceftazidime-Avibactam, Meropenem-Vaborbactam and Imipenem-Relebactam in Carbapenemase Producing Klebsiella pneumoniae Isolates
by: Özlem AYDEMİR, et al.
Published: (2023-09-01)

Simultaneous post-neurosurgical ventriculitis and bacteraemia by two different strains of KPC-producing K. pneumoniae successfully treated with meropenem/vaborbactam and high dose of fosfomycin
by: Lorenzo Volpicelli, et al.
Published: (2024-06-01)

In Vitro Activities of Cefiderocol, Ceftazidime–Avibactam, Meropenem–Vaborbactam, Imipenem–Relebactam and Eravacycline Against Carbapenem-Resistant Klebsiella pneumoniae
by: FATMA SENA TÜRKDOĞAN, et al.
Published: (2024-12-01)

Epidemiology of Carbapenemase-Producing Klebsiella pneumoniae in a Hospital, Portugal
by: Marta Aires-de-Sousa, et al.
Published: (2019-09-01)

A Novel KPC Variant KPC-55 in Klebsiella pneumoniae ST307 of Reinforced Meropenem-Hydrolyzing Activity
by: Eun-Jeong Yoon, et al.
Published: (2020-10-01)

Meropenem–Vaborbactam for the Treatment of Post-Neurosurgical Meningitis Caused by KPC Producer Klebsiella Pneumoniae: A Case Report and Review of the Literature
by: Leonardo Francesco Rezzonico, et al.
Published: (2024-04-01)

Genotypic Evolution of Klebsiella pneumoniae Sequence Type 512 during Ceftazidime/Avibactam, Meropenem/Vaborbactam, and Cefiderocol Treatment, Italy
by: Gabriele Arcari, et al.
Published: (2023-11-01)

Meropenem/Vaborbactam: β-Lactam/β-Lactamase Inhibitor Combination, the Future in Eradicating Multidrug Resistance
by: Anna Duda-Madej, et al.
Published: (2023-11-01)

Epidemiology of carbapenemase-producing Klebsiella pneumoniae in northern Portugal: Predominance of KPC-2 and OXA-48
by: Elizeth Lopes, et al.
Published: (2020-09-01)

Evaluation with E-test of the meropenem/vaborbactam association in carbapenem-resistant and sensitive negative control strains isolates of samples processed at the Laboratory of the Rivoli Hospital
by: Giuseppina Amarù, et al.
Published: (2022-05-01)

Treatment of UTIs Due to <i>Klebsiella pneumoniae</i> Carbapenemase-Producers: How to Use New Antibiotic Drugs? A Narrative Review
by: Caroline Chapelle, et al.
Published: (2021-11-01)

Effect of Colistin, Fosfomycin and Meropenem/Vaborbactam on Carbapenem-Resistant Enterobacterales in Egypt: A Cross-Sectional Study
by: Shrief R, et al.
Published: (2022-10-01)

Klebsiella pneumoniae Carbapenemase–2, Buenos Aires, Argentina
by: Fernando G. Pasteran, et al.
Published: (2008-07-01)

Meropenem/Vaborbactam Plus Aztreonam as a Possible Treatment Strategy for Bloodstream Infections Caused by Ceftazidime/Avibactam-Resistant <i>Klebsiella pneumoniae</i>: A Retrospective Case Series and Literature Review
by: Alessandra Belati, et al.
Published: (2022-03-01)

Cure of recurring Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae septic shock episodes due to complicated soft tissue infection using a ceftazidime and avibactam-based regimen: a case report
by: Giustino Parruti, et al.
Published: (2019-01-01)

An Appraisal of the Pharmacokinetic and Pharmacodynamic Properties of Meropenem-Vaborbactam
by: Eric Wenzler, et al.
Published: (2020-10-01)

Prevalence of carbapenemase-producing <i>Klebsiella pneumoniae</i> in the Gomel Region
by: D. V. Tapalski, et al.
Published: (2019-09-01)

Meropenem MICs at Standard and High Inocula and Mutant Prevention Concentration Inter-Relations: Comparative Study with Non-Carbapenemase-Producing and OXA-48-, KPC- and NDM-Producing <i>Klebsiella pneumoniae</i>
by: Maria V. Golikova, et al.
Published: (2023-05-01)

Activity of meropenem/vaborbactam against international carbapenem-resistant Escherichia coli isolates in relation to clonal background, resistance genes, resistance to comparators and region
by: Brian D. Johnston, et al.
Published: (2021-03-01)

Susceptibility evaluation of novel beta-lactam/beta-lactamase inhibitor combinations against carbapenem-resistant Klebsiella pneumoniae from bloodstream infections in hospitalized patients in Brazil
by: Camila Mörschbächer Wilhelm, et al.
Published: (2024-09-01)

Global emergence of carbapenem-resistant Klebsiella pneumoniae co-carrying multiple carbapenemases
by: Hao Guo, et al.
Published: (2023-01-01)

Epidemiological Study of an Outbreak of KPC-2 Producing Klebsiella pneumoniae in a Tertiary Hospital in Korea
by: Jun Sung Hong, et al.
Published: (2020-06-01)

KPC-producing Klebsiella pneumoniae, finally targeting Turkey
by: J. Labarca, et al.
Published: (2014-03-01)

Clinical and microbiological characterization of KPC-producing Klebsiella pneumoniae infections in Brazil
by: Elisa Maria Beirão, et al.

Association between rectal colonisation by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae and mortality: a prospective, observational study
by: Ángela Cano, et al.
Published: (2022-06-01)

Emergence of New Non–Clonal Group 258 High-Risk Clones among Klebsiella pneumoniae Carbapenemase–Producing K. pneumoniae Isolates, France
by: Rémy A. Bonnin, et al.
Published: (2020-06-01)

In vitro Activity of Meropenem-Vaborbactam versus Other Antibiotics Against Carbapenem-Resistant Escherichia coli from Southeastern China
by: Huang N, et al.
Published: (2021-06-01)

Detection of bla KPC gene among carbapenemase producing Klebsiella pneumoniae isolated from different clinical specimens at tertiary care hospital of Nepal
by: Rakshya Baral, et al.
Published: (2024-04-01)

Meropenem/Vaborbactam—A Mechanistic Review for Insight into Future Development of Combinational Therapies
by: Trae Hillyer, et al.
Published: (2024-05-01)

Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae ST258 isolated from a Japanese patient without a history of foreign travel - a new public health concern in Japan: a case report
by: Yusuke Ainoda, et al.
Published: (2019-01-01)

Treatment of <it>Klebsiella Pneumoniae</it> Carbapenemase (KPC) infections: a review of published case series and case reports
by: Lee Grace C, et al.
Published: (2012-12-01)

In vitro activity of meropenem, imipenem, cefepime, cefoxitin and ciprofloxacin against multiresistant Klebsiella pneumoniae.
by: P Pruekprasert, et al.
Published: (2006-06-01)

Clinical and molecular characteristics of KPC-producing Klebsiella pneumoniae bloodstream infections: Results of a multicentre study
by: Lucia Brescini, et al.
Published: (2025-03-01)

Effect of Ceftaroline, Ceftazidime/Avibactam, Ceftolozane/Tazobactam, and Meropenem/Vaborbactam on Establishment of Colonization by Vancomycin-Resistant Enterococci and Klebsiella pneumoniae in Mice
by: Bryan Hausman, et al.
Published: (2024-09-01)

Clinical Evaluation of Meropenem-Vaborbactam Combination for the Treatment of Urinary Tract Infection: Evidence to Date
by: Herald F, et al.
Published: (2023-01-01)

Klebsiella pneumoniae Carbapenemase-producing Enterobacteria in Hospital, Singapore
by: Indumathi Venkatachalam, et al.
Published: (2012-08-01)