Peptidoglycan-Free Bacterial Ghosts Confer Enhanced Protection against <i>Yersinia pestis</i> Infection

Peptidoglycan-Free Bacterial Ghosts Confer Enhanced Protection against <i>Yersinia pestis</i> Infection

To develop a modern plague vaccine, we used hypo-endotoxic <i>Yersinia</i> <i>pestis</i> bacterial ghosts (BGs) with combinations of genes encoding the bacteriophage ɸX174 lysis-mediating protein E and/or holin-endolysin systems from λ or L-413C phages. Expression of the prot...

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Bibliographic Details
Main Authors: Svetlana V. Dentovskaya, Anastasia S. Vagaiskaya, Mikhail E. Platonov, Alexandra S. Trunyakova, Sergei A. Kotov, Ekaterina A. Krasil’nikova, Galina M. Titareva, Elizaveta M. Mazurina, Tat’yana V. Gapel’chenkova, Rima Z. Shaikhutdinova, Sergei A. Ivanov, Tat’yana I. Kombarova, Vladimir N. Gerasimov, Vladimir N. Uversky, Andrey P. Anisimov
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Vaccines
Subjects:
<i>Yersinia pestis</i>
vaccine
guinea pigs
bubonic plague
inactivated vaccine
phage
Online Access:https://www.mdpi.com/2076-393X/10/1/51

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