The cross-talk between tumor cells and activated fibroblasts mediated by lactate/BDNF/TrkB signaling promotes acquired resistance to anlotinib in human gastric cancer

The cross-talk between tumor cells and activated fibroblasts mediated by lactate/BDNF/TrkB signaling promotes acquired resistance to anlotinib in human gastric cancer

Acquired resistance to tyrosine kinase inhibitors (TKIs) is the major obstacle to improve clinical efficacy in cancer patients. The epithelial-stromal interaction in tumor microenvironment influences cancer drug response to TKIs. Anlotinib is a novel oral multi-targeted TKI, and has recently been pr...

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Bibliographic Details
Main Authors: Zhijian Jin, Yifan Lu, Xiongyan Wu, Tao Pan, Zhenjia Yu, Junyi Hou, Airong Wu, Jianfang Li, Zhongyin Yang, Chen Li, Min Yan, Chao Yan, Zhenggang Zhu, Bingya Liu, Weihua Qiu, Liping Su
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Redox Biology
Subjects:
Fibroblast
Anlotinib
BDNF
TrkB
ROS
Nrf2
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721002354

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