An Extremely Rare Case of Prostate and Bladder Wall Involvement of Chronic Lymphocytic Leukemia
Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults and is characterized by monoclonal proliferation of B-cell lymphocytes which are morphologically mature, but immunologically dysfunctional. The primary sites of disease involvement include peripheral blood, lymph nodes, spleen,...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-04-01
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| Series: | Journal of Investigative Medicine High Impact Case Reports |
| Online Access: | https://doi.org/10.1177/23247096231168105 |
| _version_ | 1797844201093726208 |
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| author | Mathew Thomas Ali Wazir Shridevi Karikehalli Michael Sandhu Aarati Poudel |
| author_facet | Mathew Thomas Ali Wazir Shridevi Karikehalli Michael Sandhu Aarati Poudel |
| author_sort | Mathew Thomas |
| collection | DOAJ |
| description | Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults and is characterized by monoclonal proliferation of B-cell lymphocytes which are morphologically mature, but immunologically dysfunctional. The primary sites of disease involvement include peripheral blood, lymph nodes, spleen, and bone marrow. CLL can also present locally and aggressively at extranodal sites. We describe the case of a 74-year-old gentleman with multiple medical comorbidities who was Foley catheter–dependent at baseline for bladder outlet obstruction. He was detected to have Rai stage I CLL following an inguinal lymph node biopsy and was on regular outpatient surveillance. Later, he underwent a prostate biopsy for evaluation of hematuria, results of which were consistent with CLL involvement in the prostate and urinary bladder. The patient was started on single-agent ibrutinib, and demonstrated an excellent clinical response to bladder outlet obstruction. His long-term Foley catheter was discontinued within 5 days of ibrutinib therapy. Unfortunately, 1 year later, he had disease progression, and therapy was changed to a single-agent rituximab, to which he is responding well. Our case is unique as it brings up the first reported case of prostate and bladder wall CLL. |
| first_indexed | 2024-04-09T17:18:31Z |
| format | Article |
| id | doaj.art-916bdf72dc394b32b4377d176a62e46f |
| institution | Directory Open Access Journal |
| issn | 2324-7096 |
| language | English |
| last_indexed | 2024-04-09T17:18:31Z |
| publishDate | 2023-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Investigative Medicine High Impact Case Reports |
| spelling | doaj.art-916bdf72dc394b32b4377d176a62e46f2023-04-19T07:33:31ZengSAGE PublishingJournal of Investigative Medicine High Impact Case Reports2324-70962023-04-011110.1177/23247096231168105An Extremely Rare Case of Prostate and Bladder Wall Involvement of Chronic Lymphocytic LeukemiaMathew Thomas0Ali Wazir1Shridevi Karikehalli2Michael Sandhu3Aarati Poudel4State University of New York (SUNY) Upstate Medical University, Syracuse, USAState University of New York (SUNY) Upstate Medical University, Syracuse, USAVA Medical Center, Syracuse, NY, USAState University of New York (SUNY) Upstate Medical University, Syracuse, USAVA Medical Center, Syracuse, NY, USAChronic lymphocytic leukemia (CLL) is the most common leukemia in adults and is characterized by monoclonal proliferation of B-cell lymphocytes which are morphologically mature, but immunologically dysfunctional. The primary sites of disease involvement include peripheral blood, lymph nodes, spleen, and bone marrow. CLL can also present locally and aggressively at extranodal sites. We describe the case of a 74-year-old gentleman with multiple medical comorbidities who was Foley catheter–dependent at baseline for bladder outlet obstruction. He was detected to have Rai stage I CLL following an inguinal lymph node biopsy and was on regular outpatient surveillance. Later, he underwent a prostate biopsy for evaluation of hematuria, results of which were consistent with CLL involvement in the prostate and urinary bladder. The patient was started on single-agent ibrutinib, and demonstrated an excellent clinical response to bladder outlet obstruction. His long-term Foley catheter was discontinued within 5 days of ibrutinib therapy. Unfortunately, 1 year later, he had disease progression, and therapy was changed to a single-agent rituximab, to which he is responding well. Our case is unique as it brings up the first reported case of prostate and bladder wall CLL.https://doi.org/10.1177/23247096231168105 |
| spellingShingle | Mathew Thomas Ali Wazir Shridevi Karikehalli Michael Sandhu Aarati Poudel An Extremely Rare Case of Prostate and Bladder Wall Involvement of Chronic Lymphocytic Leukemia Journal of Investigative Medicine High Impact Case Reports |
| title | An Extremely Rare Case of Prostate and Bladder Wall Involvement of Chronic Lymphocytic Leukemia |
| title_full | An Extremely Rare Case of Prostate and Bladder Wall Involvement of Chronic Lymphocytic Leukemia |
| title_fullStr | An Extremely Rare Case of Prostate and Bladder Wall Involvement of Chronic Lymphocytic Leukemia |
| title_full_unstemmed | An Extremely Rare Case of Prostate and Bladder Wall Involvement of Chronic Lymphocytic Leukemia |
| title_short | An Extremely Rare Case of Prostate and Bladder Wall Involvement of Chronic Lymphocytic Leukemia |
| title_sort | extremely rare case of prostate and bladder wall involvement of chronic lymphocytic leukemia |
| url | https://doi.org/10.1177/23247096231168105 |
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