The Ubiquitin–Proteasome System in Immune Cells
The ubiquitin–proteasome system (UPS) is the major intracellular and non-lysosomal protein degradation system. Thanks to its unique capacity of eliminating old, damaged, misfolded, and/or regulatory proteins in a highly specific manner, the UPS is virtually involved in almost all aspects of eukaryot...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-01-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/11/1/60 |
| _version_ | 1797542262475849728 |
|---|---|
| author | Gonca Çetin Sandro Klafack Maja Studencka-Turski Elke Krüger Frédéric Ebstein |
| author_facet | Gonca Çetin Sandro Klafack Maja Studencka-Turski Elke Krüger Frédéric Ebstein |
| author_sort | Gonca Çetin |
| collection | DOAJ |
| description | The ubiquitin–proteasome system (UPS) is the major intracellular and non-lysosomal protein degradation system. Thanks to its unique capacity of eliminating old, damaged, misfolded, and/or regulatory proteins in a highly specific manner, the UPS is virtually involved in almost all aspects of eukaryotic life. The critical importance of the UPS is particularly visible in immune cells which undergo a rapid and profound functional remodelling upon pathogen recognition. Innate and/or adaptive immune activation is indeed characterized by a number of substantial changes impacting various cellular processes including protein homeostasis, signal transduction, cell proliferation, and antigen processing which are all tightly regulated by the UPS. In this review, we summarize and discuss recent progress in our understanding of the molecular mechanisms by which the UPS contributes to the generation of an adequate immune response. In this regard, we also discuss the consequences of UPS dysfunction and its role in the pathogenesis of recently described immune disorders including cancer and auto-inflammatory diseases. |
| first_indexed | 2024-03-10T13:28:11Z |
| format | Article |
| id | doaj.art-916c8a143a9e4f588071c03c857e39ef |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T13:28:11Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-916c8a143a9e4f588071c03c857e39ef2023-11-21T08:39:20ZengMDPI AGBiomolecules2218-273X2021-01-011116010.3390/biom11010060The Ubiquitin–Proteasome System in Immune CellsGonca Çetin0Sandro Klafack1Maja Studencka-Turski2Elke Krüger3Frédéric Ebstein4Institute of Medical Biochemistry and Molecular Biology, Universitätsmedizin Greifswald, D-17475 Greifswald, GermanyInstitute of Medical Biochemistry and Molecular Biology, Universitätsmedizin Greifswald, D-17475 Greifswald, GermanyInstitute of Medical Biochemistry and Molecular Biology, Universitätsmedizin Greifswald, D-17475 Greifswald, GermanyInstitute of Medical Biochemistry and Molecular Biology, Universitätsmedizin Greifswald, D-17475 Greifswald, GermanyInstitute of Medical Biochemistry and Molecular Biology, Universitätsmedizin Greifswald, D-17475 Greifswald, GermanyThe ubiquitin–proteasome system (UPS) is the major intracellular and non-lysosomal protein degradation system. Thanks to its unique capacity of eliminating old, damaged, misfolded, and/or regulatory proteins in a highly specific manner, the UPS is virtually involved in almost all aspects of eukaryotic life. The critical importance of the UPS is particularly visible in immune cells which undergo a rapid and profound functional remodelling upon pathogen recognition. Innate and/or adaptive immune activation is indeed characterized by a number of substantial changes impacting various cellular processes including protein homeostasis, signal transduction, cell proliferation, and antigen processing which are all tightly regulated by the UPS. In this review, we summarize and discuss recent progress in our understanding of the molecular mechanisms by which the UPS contributes to the generation of an adequate immune response. In this regard, we also discuss the consequences of UPS dysfunction and its role in the pathogenesis of recently described immune disorders including cancer and auto-inflammatory diseases.https://www.mdpi.com/2218-273X/11/1/60ubiquitin–proteasome systemproteostasisimmunityautoinflammationcancer |
| spellingShingle | Gonca Çetin Sandro Klafack Maja Studencka-Turski Elke Krüger Frédéric Ebstein The Ubiquitin–Proteasome System in Immune Cells Biomolecules ubiquitin–proteasome system proteostasis immunity autoinflammation cancer |
| title | The Ubiquitin–Proteasome System in Immune Cells |
| title_full | The Ubiquitin–Proteasome System in Immune Cells |
| title_fullStr | The Ubiquitin–Proteasome System in Immune Cells |
| title_full_unstemmed | The Ubiquitin–Proteasome System in Immune Cells |
| title_short | The Ubiquitin–Proteasome System in Immune Cells |
| title_sort | ubiquitin proteasome system in immune cells |
| topic | ubiquitin–proteasome system proteostasis immunity autoinflammation cancer |
| url | https://www.mdpi.com/2218-273X/11/1/60 |
| work_keys_str_mv | AT goncacetin theubiquitinproteasomesysteminimmunecells AT sandroklafack theubiquitinproteasomesysteminimmunecells AT majastudenckaturski theubiquitinproteasomesysteminimmunecells AT elkekruger theubiquitinproteasomesysteminimmunecells AT fredericebstein theubiquitinproteasomesysteminimmunecells AT goncacetin ubiquitinproteasomesysteminimmunecells AT sandroklafack ubiquitinproteasomesysteminimmunecells AT majastudenckaturski ubiquitinproteasomesysteminimmunecells AT elkekruger ubiquitinproteasomesysteminimmunecells AT fredericebstein ubiquitinproteasomesysteminimmunecells |