Nascent peptide-induced translation discontinuation in eukaryotes impacts biased amino acid usage in proteomes
Here the authors find that nascent chains enriched in acidic amino acids destabilize the translating ribosome, eventually leading to stochastic premature termination in eukaryotes as in bacteria. Such risk of premature termination influences the amino acid distribution in the proteomes.
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35156-x |
| _version_ | 1811190403297181696 |
|---|---|
| author | Yosuke Ito Yuhei Chadani Tatsuya Niwa Ayako Yamakawa Kodai Machida Hiroaki Imataka Hideki Taguchi |
| author_facet | Yosuke Ito Yuhei Chadani Tatsuya Niwa Ayako Yamakawa Kodai Machida Hiroaki Imataka Hideki Taguchi |
| author_sort | Yosuke Ito |
| collection | DOAJ |
| description | Here the authors find that nascent chains enriched in acidic amino acids destabilize the translating ribosome, eventually leading to stochastic premature termination in eukaryotes as in bacteria. Such risk of premature termination influences the amino acid distribution in the proteomes. |
| first_indexed | 2024-04-11T14:50:49Z |
| format | Article |
| id | doaj.art-916d1174a4b24e219937c6f63becb21d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T14:50:49Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-916d1174a4b24e219937c6f63becb21d2022-12-22T04:17:29ZengNature PortfolioNature Communications2041-17232022-12-0113111610.1038/s41467-022-35156-xNascent peptide-induced translation discontinuation in eukaryotes impacts biased amino acid usage in proteomesYosuke Ito0Yuhei Chadani1Tatsuya Niwa2Ayako Yamakawa3Kodai Machida4Hiroaki Imataka5Hideki Taguchi6School of Life Science and Technology, Tokyo Institute of TechnologyCell Biology Center, Institute of Innovative Research, Tokyo Institute of TechnologySchool of Life Science and Technology, Tokyo Institute of TechnologySchool of Life Science and Technology, Tokyo Institute of TechnologyGraduate School of Engineering, University of HyogoGraduate School of Engineering, University of HyogoSchool of Life Science and Technology, Tokyo Institute of TechnologyHere the authors find that nascent chains enriched in acidic amino acids destabilize the translating ribosome, eventually leading to stochastic premature termination in eukaryotes as in bacteria. Such risk of premature termination influences the amino acid distribution in the proteomes.https://doi.org/10.1038/s41467-022-35156-x |
| spellingShingle | Yosuke Ito Yuhei Chadani Tatsuya Niwa Ayako Yamakawa Kodai Machida Hiroaki Imataka Hideki Taguchi Nascent peptide-induced translation discontinuation in eukaryotes impacts biased amino acid usage in proteomes Nature Communications |
| title | Nascent peptide-induced translation discontinuation in eukaryotes impacts biased amino acid usage in proteomes |
| title_full | Nascent peptide-induced translation discontinuation in eukaryotes impacts biased amino acid usage in proteomes |
| title_fullStr | Nascent peptide-induced translation discontinuation in eukaryotes impacts biased amino acid usage in proteomes |
| title_full_unstemmed | Nascent peptide-induced translation discontinuation in eukaryotes impacts biased amino acid usage in proteomes |
| title_short | Nascent peptide-induced translation discontinuation in eukaryotes impacts biased amino acid usage in proteomes |
| title_sort | nascent peptide induced translation discontinuation in eukaryotes impacts biased amino acid usage in proteomes |
| url | https://doi.org/10.1038/s41467-022-35156-x |
| work_keys_str_mv | AT yosukeito nascentpeptideinducedtranslationdiscontinuationineukaryotesimpactsbiasedaminoacidusageinproteomes AT yuheichadani nascentpeptideinducedtranslationdiscontinuationineukaryotesimpactsbiasedaminoacidusageinproteomes AT tatsuyaniwa nascentpeptideinducedtranslationdiscontinuationineukaryotesimpactsbiasedaminoacidusageinproteomes AT ayakoyamakawa nascentpeptideinducedtranslationdiscontinuationineukaryotesimpactsbiasedaminoacidusageinproteomes AT kodaimachida nascentpeptideinducedtranslationdiscontinuationineukaryotesimpactsbiasedaminoacidusageinproteomes AT hiroakiimataka nascentpeptideinducedtranslationdiscontinuationineukaryotesimpactsbiasedaminoacidusageinproteomes AT hidekitaguchi nascentpeptideinducedtranslationdiscontinuationineukaryotesimpactsbiasedaminoacidusageinproteomes |