Intraparotid lymph node metastasis affects distant metastasis in parotid adenoid cystic carcinoma
Abstract To evaluate the relationship between factors of metastatic intraparotid lymph node (IPLN) and distant metastasis in parotid adenoid cystic carcinoma (ACC). Patients with surgically treated parotid ACC were retrospectively enrolled, and primary outcome variable was distant metastasis free su...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-38227-1 |
| _version_ | 1797778915709681664 |
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| author | Xiaoxue Han Jia Wang Yuexiao Li Shanlong Xi Weiwei Xiao |
| author_facet | Xiaoxue Han Jia Wang Yuexiao Li Shanlong Xi Weiwei Xiao |
| author_sort | Xiaoxue Han |
| collection | DOAJ |
| description | Abstract To evaluate the relationship between factors of metastatic intraparotid lymph node (IPLN) and distant metastasis in parotid adenoid cystic carcinoma (ACC). Patients with surgically treated parotid ACC were retrospectively enrolled, and primary outcome variable was distant metastasis free survival (DMFS). The effect of factors of metastatic IPLN on DMFS was evaluated using Cox model. In total, 232 patients were included. Extranodal extension of IPLN and cervical lymph nodes did not impact the DMFS, and the 7th but not 8th AJCC N stage was associated with DMFS. Groups of 0 and 1 metastatic IPLN had comparable DMFS, but presence of 2+ positive IPLN was related to increased worse DMFS (p = 0.034, HR 2.09). A new N stage (0 vs 1–2 vs 3+) based on total positive lymph node number exhibited better C-index than traditional N stage. IPLN metastasis increased the risk of distant metastasis, and the impact was mainly determined by the number of metastatic IPLN. Our proposed N stage provided better DMFS prediction than the 8th AJCC N classification. |
| first_indexed | 2024-03-12T23:24:25Z |
| format | Article |
| id | doaj.art-916d3f778f874ca0ad3d5ee5a02a4791 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-12T23:24:25Z |
| publishDate | 2023-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-916d3f778f874ca0ad3d5ee5a02a47912023-07-16T11:16:44ZengNature PortfolioScientific Reports2045-23222023-07-011311710.1038/s41598-023-38227-1Intraparotid lymph node metastasis affects distant metastasis in parotid adenoid cystic carcinomaXiaoxue Han0Jia Wang1Yuexiao Li2Shanlong Xi3Weiwei Xiao4Department of Oral Maxillofacial Surgery, Affiliated Stomatology Hospital of China Medical UniversityDepartment of Oral Maxillofacial Surgery, Affiliated Stomatology Hospital of China Medical UniversityDepartment of Oral Maxillofacial Surgery, Affiliated Stomatology Hospital of China Medical UniversityDepartment of Oral Maxillofacial Surgery, Affiliated Stomatology Hospital of China Medical UniversityDepartment of Thoracic Surgery, The First Affiliated Hospital of China Medical UniversityAbstract To evaluate the relationship between factors of metastatic intraparotid lymph node (IPLN) and distant metastasis in parotid adenoid cystic carcinoma (ACC). Patients with surgically treated parotid ACC were retrospectively enrolled, and primary outcome variable was distant metastasis free survival (DMFS). The effect of factors of metastatic IPLN on DMFS was evaluated using Cox model. In total, 232 patients were included. Extranodal extension of IPLN and cervical lymph nodes did not impact the DMFS, and the 7th but not 8th AJCC N stage was associated with DMFS. Groups of 0 and 1 metastatic IPLN had comparable DMFS, but presence of 2+ positive IPLN was related to increased worse DMFS (p = 0.034, HR 2.09). A new N stage (0 vs 1–2 vs 3+) based on total positive lymph node number exhibited better C-index than traditional N stage. IPLN metastasis increased the risk of distant metastasis, and the impact was mainly determined by the number of metastatic IPLN. Our proposed N stage provided better DMFS prediction than the 8th AJCC N classification.https://doi.org/10.1038/s41598-023-38227-1 |
| spellingShingle | Xiaoxue Han Jia Wang Yuexiao Li Shanlong Xi Weiwei Xiao Intraparotid lymph node metastasis affects distant metastasis in parotid adenoid cystic carcinoma Scientific Reports |
| title | Intraparotid lymph node metastasis affects distant metastasis in parotid adenoid cystic carcinoma |
| title_full | Intraparotid lymph node metastasis affects distant metastasis in parotid adenoid cystic carcinoma |
| title_fullStr | Intraparotid lymph node metastasis affects distant metastasis in parotid adenoid cystic carcinoma |
| title_full_unstemmed | Intraparotid lymph node metastasis affects distant metastasis in parotid adenoid cystic carcinoma |
| title_short | Intraparotid lymph node metastasis affects distant metastasis in parotid adenoid cystic carcinoma |
| title_sort | intraparotid lymph node metastasis affects distant metastasis in parotid adenoid cystic carcinoma |
| url | https://doi.org/10.1038/s41598-023-38227-1 |
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