The effect of metabolic syndrome on postoperative complications and long-term survival of patients with colorectal cancer
BackgroundMetabolic syndrome (MetS) is associated with poor prognosis in many cancers. However, the relationship between metabolic syndrome and overall survival (OS) in patients with colorectal cancer (CRC) remains unclear. We aimed to comprehensively analyze whether MetS could affect postoperative...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1036458/full |
| _version_ | 1797794711975493632 |
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| author | Ce Zhu Chenchen Mao Wentao Cai Jingwei Zheng Hui Yang Tao You Jian Chen Yaojun Yu Xian Shen Xian Shen Liyi Li |
| author_facet | Ce Zhu Chenchen Mao Wentao Cai Jingwei Zheng Hui Yang Tao You Jian Chen Yaojun Yu Xian Shen Xian Shen Liyi Li |
| author_sort | Ce Zhu |
| collection | DOAJ |
| description | BackgroundMetabolic syndrome (MetS) is associated with poor prognosis in many cancers. However, the relationship between metabolic syndrome and overall survival (OS) in patients with colorectal cancer (CRC) remains unclear. We aimed to comprehensively analyze whether MetS could affect postoperative complications and long-term survival in patients with CRC.MethodsWe included patients who underwent CRC resection at our center between January 2016 and December 2018. Bias was reduced through propensity score matching analysis. Patients with CRC were divided into the MetS and non-MetS groups based on whether they had MetS. Univariate and multivariate analyses were used to identify risk factors affecting OS.ResultsWe included 268 patients; among them, 120 were included for further analysis after propensity score matching. There were no significant between-group differences in the clinicopathological features after matching. Compared with the non-MetS group, the MetS group had a shorter OS (P = 0.027); however, there was no significant between-group difference in postoperative complications. Multivariate analysis revealed that MetS (hazard ratio [HR] = 1.997, P = 0.042), tumor-node-metastasis stage (HR = 2.422, P = 0.003), and intestinal obstruction (HR = 2.761, P = 0.010) were independent risk factors for OS.ConclusionsMetS affects the long-term survival of patients with CRC without affecting postoperative complications. |
| first_indexed | 2024-03-13T03:06:54Z |
| format | Article |
| id | doaj.art-916d6784b4f5425aa6bdc3a16a322315 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-13T03:06:54Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-916d6784b4f5425aa6bdc3a16a3223152023-06-26T19:24:41ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-06-011310.3389/fonc.2023.10364581036458The effect of metabolic syndrome on postoperative complications and long-term survival of patients with colorectal cancerCe Zhu0Chenchen Mao1Wentao Cai2Jingwei Zheng3Hui Yang4Tao You5Jian Chen6Yaojun Yu7Xian Shen8Xian Shen9Liyi Li10Department of Gastrointestinal Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Institute of Molecular Virology and Immunology, Wenzhou Medical University, Zhejiang, ChinaDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaBackgroundMetabolic syndrome (MetS) is associated with poor prognosis in many cancers. However, the relationship between metabolic syndrome and overall survival (OS) in patients with colorectal cancer (CRC) remains unclear. We aimed to comprehensively analyze whether MetS could affect postoperative complications and long-term survival in patients with CRC.MethodsWe included patients who underwent CRC resection at our center between January 2016 and December 2018. Bias was reduced through propensity score matching analysis. Patients with CRC were divided into the MetS and non-MetS groups based on whether they had MetS. Univariate and multivariate analyses were used to identify risk factors affecting OS.ResultsWe included 268 patients; among them, 120 were included for further analysis after propensity score matching. There were no significant between-group differences in the clinicopathological features after matching. Compared with the non-MetS group, the MetS group had a shorter OS (P = 0.027); however, there was no significant between-group difference in postoperative complications. Multivariate analysis revealed that MetS (hazard ratio [HR] = 1.997, P = 0.042), tumor-node-metastasis stage (HR = 2.422, P = 0.003), and intestinal obstruction (HR = 2.761, P = 0.010) were independent risk factors for OS.ConclusionsMetS affects the long-term survival of patients with CRC without affecting postoperative complications.https://www.frontiersin.org/articles/10.3389/fonc.2023.1036458/fullmetabolic syndromecolorectal canceroverall survivalpostoperative complicationspropensity score matching |
| spellingShingle | Ce Zhu Chenchen Mao Wentao Cai Jingwei Zheng Hui Yang Tao You Jian Chen Yaojun Yu Xian Shen Xian Shen Liyi Li The effect of metabolic syndrome on postoperative complications and long-term survival of patients with colorectal cancer Frontiers in Oncology metabolic syndrome colorectal cancer overall survival postoperative complications propensity score matching |
| title | The effect of metabolic syndrome on postoperative complications and long-term survival of patients with colorectal cancer |
| title_full | The effect of metabolic syndrome on postoperative complications and long-term survival of patients with colorectal cancer |
| title_fullStr | The effect of metabolic syndrome on postoperative complications and long-term survival of patients with colorectal cancer |
| title_full_unstemmed | The effect of metabolic syndrome on postoperative complications and long-term survival of patients with colorectal cancer |
| title_short | The effect of metabolic syndrome on postoperative complications and long-term survival of patients with colorectal cancer |
| title_sort | effect of metabolic syndrome on postoperative complications and long term survival of patients with colorectal cancer |
| topic | metabolic syndrome colorectal cancer overall survival postoperative complications propensity score matching |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1036458/full |
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