HLA-B*27 is associated with CNO in a European cohort
Abstract Objectives To determine the influence of HLA-B27 positivity on risk of developing chronic nonbacterial osteomyelitis (CNO). Methods HLA-B*27 genotype was assessed in 3 European CNO populations and compared with local control populations (572 cases, 33,256 controls). Regional or whole-body M...
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | Pediatric Rheumatology Online Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12969-023-00826-7 |
| _version_ | 1827928793622249472 |
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| author | Daire O’Leary Dalila Ali Al Julandani Muhammad Zia Jens Klotsche Kirsten Minden Marion Roderick Athimalaipet V. Ramanan Orla G. Killeen Anthony G. Wilson |
| author_facet | Daire O’Leary Dalila Ali Al Julandani Muhammad Zia Jens Klotsche Kirsten Minden Marion Roderick Athimalaipet V. Ramanan Orla G. Killeen Anthony G. Wilson |
| author_sort | Daire O’Leary |
| collection | DOAJ |
| description | Abstract Objectives To determine the influence of HLA-B27 positivity on risk of developing chronic nonbacterial osteomyelitis (CNO). Methods HLA-B*27 genotype was assessed in 3 European CNO populations and compared with local control populations (572 cases, 33,256 controls). Regional or whole-body MRI was performed at diagnosis and follow-up in all cases which reduces the risk of disease misclassification. Genotyping was performed using either next generation DNA sequencing or PCR based molecular typing. Statistical analysis used Fisher’s exact test with Bonferroni correction and a fixed effects model for meta-analysis of odds ratios. Results HLA-B*27 frequency was higher in all 3 populations compared with local controls (combined odds ratio (OR) = 2.2, p-value = 3 × 10–11). This association was much stronger in male compared with female cases (OR = 1.99, corrected p-value = 0.015). However, the HLA-B*27 status was not statistically significantly associated with co-occurrence of psoriasis, arthritis or inflammatory bowel disease. Conclusion Carriage of HLA-B*27 is associated with greater risk of developing CNO, particularly in male cases. |
| first_indexed | 2024-03-13T06:13:44Z |
| format | Article |
| id | doaj.art-916db92c85794bcdb5168be407bbe5d1 |
| institution | Directory Open Access Journal |
| issn | 1546-0096 |
| language | English |
| last_indexed | 2024-03-13T06:13:44Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Pediatric Rheumatology Online Journal |
| spelling | doaj.art-916db92c85794bcdb5168be407bbe5d12023-06-11T11:08:08ZengBMCPediatric Rheumatology Online Journal1546-00962023-06-012111610.1186/s12969-023-00826-7HLA-B*27 is associated with CNO in a European cohortDaire O’Leary0Dalila Ali Al Julandani1Muhammad Zia2Jens Klotsche3Kirsten Minden4Marion Roderick5Athimalaipet V. Ramanan6Orla G. Killeen7Anthony G. Wilson8Centre for Arthritis Research, Conway Institute, School of Medicine, University College DublinDepartment of Paediatric Rheumatology, Bristol Royal Hospital for ChildrenNational Centre for Paediatric Rheumatology, Children’s Health IrelandDeutsches Rheuma-Forschungszentrum Berlin, Leibniz InstituteDeutsches Rheuma-Forschungszentrum Berlin, Leibniz InstituteDepartment of Paediatric Immunology and Infectious Diseases, Bristol Royal Hospital for ChildrenDepartment of Paediatric Rheumatology, Bristol Royal Hospital for ChildrenCentre for Arthritis Research, Conway Institute, School of Medicine, University College DublinCentre for Arthritis Research, Conway Institute, School of Medicine, University College DublinAbstract Objectives To determine the influence of HLA-B27 positivity on risk of developing chronic nonbacterial osteomyelitis (CNO). Methods HLA-B*27 genotype was assessed in 3 European CNO populations and compared with local control populations (572 cases, 33,256 controls). Regional or whole-body MRI was performed at diagnosis and follow-up in all cases which reduces the risk of disease misclassification. Genotyping was performed using either next generation DNA sequencing or PCR based molecular typing. Statistical analysis used Fisher’s exact test with Bonferroni correction and a fixed effects model for meta-analysis of odds ratios. Results HLA-B*27 frequency was higher in all 3 populations compared with local controls (combined odds ratio (OR) = 2.2, p-value = 3 × 10–11). This association was much stronger in male compared with female cases (OR = 1.99, corrected p-value = 0.015). However, the HLA-B*27 status was not statistically significantly associated with co-occurrence of psoriasis, arthritis or inflammatory bowel disease. Conclusion Carriage of HLA-B*27 is associated with greater risk of developing CNO, particularly in male cases.https://doi.org/10.1186/s12969-023-00826-7Paediatric rheumatologyChronic nonbacterial osteomyelitisCNOCRMOHLA |
| spellingShingle | Daire O’Leary Dalila Ali Al Julandani Muhammad Zia Jens Klotsche Kirsten Minden Marion Roderick Athimalaipet V. Ramanan Orla G. Killeen Anthony G. Wilson HLA-B*27 is associated with CNO in a European cohort Pediatric Rheumatology Online Journal Paediatric rheumatology Chronic nonbacterial osteomyelitis CNO CRMO HLA |
| title | HLA-B*27 is associated with CNO in a European cohort |
| title_full | HLA-B*27 is associated with CNO in a European cohort |
| title_fullStr | HLA-B*27 is associated with CNO in a European cohort |
| title_full_unstemmed | HLA-B*27 is associated with CNO in a European cohort |
| title_short | HLA-B*27 is associated with CNO in a European cohort |
| title_sort | hla b 27 is associated with cno in a european cohort |
| topic | Paediatric rheumatology Chronic nonbacterial osteomyelitis CNO CRMO HLA |
| url | https://doi.org/10.1186/s12969-023-00826-7 |
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