Selenium and manganese in depression – preclinical and clinical studies
According to the World Health Organization estimates, approximately 10% of the world’s population is affected by depressive disorders. Furthermore, even in high-income countries, many people with depression are not treated, which can lead to serious health consequences and a global economic loss. Un...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2017-09-01
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| Series: | Current Issues in Pharmacy and Medical Sciences |
| Subjects: | |
| Online Access: | http://www.degruyter.com/view/j/cipms.2017.30.issue-3/cipms-2017-0028/cipms-2017-0028.xml?format=INT |
| _version_ | 1819091799025647616 |
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| author | Slawinska Karolina Bielecka Gabriela Iwaniak Karol Wosko Sylwia Poleszak Ewa |
| author_facet | Slawinska Karolina Bielecka Gabriela Iwaniak Karol Wosko Sylwia Poleszak Ewa |
| author_sort | Slawinska Karolina |
| collection | DOAJ |
| description | According to the World Health Organization estimates, approximately 10% of the world’s population is affected by depressive disorders. Furthermore, even in high-income countries, many people with depression are not treated, which can lead to serious health consequences and a global economic loss. Unfortunately, the current pharmacotherapy of depressive disorders is characterized by unsatisfactory efficacy and the therapeutic effect is accompanied by many side effects. For this reason, there is still ongoing worldwide research to find new antidepressant therapies. In recent years, many data have been shown that essential elements demonstrate the antidepressant action and increase the effect of antidepressants. In this paper we present the results from the preclinical and clinical studies published over the years which show the involvement of selenium and manganese in depressive disorders. In this article, the relationship between the amount of these microelements in a diet and depression is reviewed and what's more, the association among these elements in different biomaterial and their relations to depressive symptoms is presented. Additionally, we discuss the possible influence of selenium and manganese on modulating neurotransmitter system involved in depression. |
| first_indexed | 2024-12-21T22:45:27Z |
| format | Article |
| id | doaj.art-916e42f92aee4a45ad1b4da8624f69ad |
| institution | Directory Open Access Journal |
| issn | 2300-6676 |
| language | English |
| last_indexed | 2024-12-21T22:45:27Z |
| publishDate | 2017-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Current Issues in Pharmacy and Medical Sciences |
| spelling | doaj.art-916e42f92aee4a45ad1b4da8624f69ad2022-12-21T18:47:44ZengSciendoCurrent Issues in Pharmacy and Medical Sciences2300-66762017-09-0130315115510.1515/cipms-2017-0028cipms-2017-0028Selenium and manganese in depression – preclinical and clinical studiesSlawinska Karolina0Bielecka Gabriela1Iwaniak Karol2Wosko Sylwia3Poleszak Ewa4Chair and Department of Applied Pharmacy, Medical University of Lublin, Chodzki 1, 20-093 Lublin, PolandChair and Department of Applied Pharmacy, Medical University of Lublin, Chodzki 1, 20-093 Lublin, PolandChair and Department of Applied Pharmacy, Medical University of Lublin, Chodzki 1, 20-093 Lublin, PolandChair and Department of Applied Pharmacy, Medical University of Lublin, Chodzki 1, 20-093 Lublin, PolandChair and Department of Applied Pharmacy, Medical University of Lublin, Chodzki 1, 20-093 Lublin, PolandAccording to the World Health Organization estimates, approximately 10% of the world’s population is affected by depressive disorders. Furthermore, even in high-income countries, many people with depression are not treated, which can lead to serious health consequences and a global economic loss. Unfortunately, the current pharmacotherapy of depressive disorders is characterized by unsatisfactory efficacy and the therapeutic effect is accompanied by many side effects. For this reason, there is still ongoing worldwide research to find new antidepressant therapies. In recent years, many data have been shown that essential elements demonstrate the antidepressant action and increase the effect of antidepressants. In this paper we present the results from the preclinical and clinical studies published over the years which show the involvement of selenium and manganese in depressive disorders. In this article, the relationship between the amount of these microelements in a diet and depression is reviewed and what's more, the association among these elements in different biomaterial and their relations to depressive symptoms is presented. Additionally, we discuss the possible influence of selenium and manganese on modulating neurotransmitter system involved in depression.http://www.degruyter.com/view/j/cipms.2017.30.issue-3/cipms-2017-0028/cipms-2017-0028.xml?format=INTdepressive disordersdietary intakemanganesepreclinical and clinical studiesselenium |
| spellingShingle | Slawinska Karolina Bielecka Gabriela Iwaniak Karol Wosko Sylwia Poleszak Ewa Selenium and manganese in depression – preclinical and clinical studies Current Issues in Pharmacy and Medical Sciences depressive disorders dietary intake manganese preclinical and clinical studies selenium |
| title | Selenium and manganese in depression – preclinical and clinical studies |
| title_full | Selenium and manganese in depression – preclinical and clinical studies |
| title_fullStr | Selenium and manganese in depression – preclinical and clinical studies |
| title_full_unstemmed | Selenium and manganese in depression – preclinical and clinical studies |
| title_short | Selenium and manganese in depression – preclinical and clinical studies |
| title_sort | selenium and manganese in depression preclinical and clinical studies |
| topic | depressive disorders dietary intake manganese preclinical and clinical studies selenium |
| url | http://www.degruyter.com/view/j/cipms.2017.30.issue-3/cipms-2017-0028/cipms-2017-0028.xml?format=INT |
| work_keys_str_mv | AT slawinskakarolina seleniumandmanganeseindepressionpreclinicalandclinicalstudies AT bieleckagabriela seleniumandmanganeseindepressionpreclinicalandclinicalstudies AT iwaniakkarol seleniumandmanganeseindepressionpreclinicalandclinicalstudies AT woskosylwia seleniumandmanganeseindepressionpreclinicalandclinicalstudies AT poleszakewa seleniumandmanganeseindepressionpreclinicalandclinicalstudies |