The Second Wind in McArdle Patients: Fitness Matters
Background: The “second wind” (SW) phenomenon—commonly referring to both an initial period of marked intolerance to dynamic exercise (e.g., brisk walking) that is not followed by perceived improvement and disappearance of previous tachycardia (i.e., the actual “SW”) until 6–10 min has elapsed—is an...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2021.744632/full |
| _version_ | 1819029488873242624 |
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| author | Eduardo Salazar-Martínez Alfredo Santalla Alfredo Santalla Pedro L. Valenzuela Gisela Nogales-Gadea Tomàs Pinós Tomàs Pinós María Morán María Morán Alejandro Santos-Lozano Alejandro Santos-Lozano Carmen Fiuza-Luces Alejandro Lucia Alejandro Lucia |
| author_facet | Eduardo Salazar-Martínez Alfredo Santalla Alfredo Santalla Pedro L. Valenzuela Gisela Nogales-Gadea Tomàs Pinós Tomàs Pinós María Morán María Morán Alejandro Santos-Lozano Alejandro Santos-Lozano Carmen Fiuza-Luces Alejandro Lucia Alejandro Lucia |
| author_sort | Eduardo Salazar-Martínez |
| collection | DOAJ |
| description | Background: The “second wind” (SW) phenomenon—commonly referring to both an initial period of marked intolerance to dynamic exercise (e.g., brisk walking) that is not followed by perceived improvement and disappearance of previous tachycardia (i.e., the actual “SW”) until 6–10 min has elapsed—is an almost unique feature of McArdle disease that limits adherence to an active lifestyle. In this regard, an increase in the workload eliciting the SW could potentially translate into an improved patients’ exercise tolerance in daily life. We aimed to determine whether aerobic fitness and physical activity (PA) levels are correlated with the minimum workload eliciting the SW in McArdle patients—as well as with the corresponding heart rate value. We also compared the SW variables and aerobic fitness indicators in inactive vs. active patients.Methods: Fifty-four McArdle patients (24 women, mean ± SD age 33 ± 12 years) performed 12-min constant-load and maximum ramp-like cycle-ergometer tests for SW detection and aerobic fitness [peak oxygen uptake (VO2peak) and workload and ventilatory threshold] determination, respectively. They were categorized as physically active/inactive during the prior 6 months (active = reporting ≥150 min/week or ≥75 min/week in moderate or vigorous-intensity aerobic PA, respectively) and were also asked on their self-report of the SW.Results: Both peak and submaximal indicators of aerobic fitness obtained in the ramp tests were significantly correlated with the workload of the SW test, with a particularly strong correlation for the VO2peak and peak workload attained by the patients (both Pearson’s coefficients > 0.70). Twenty (seven women) and 24 patients (18 women) were categorized as physically active and inactive, respectively. Not only the aerobic fitness level [∼18–19% higher values of VO2peak (ml⋅kg–1⋅min–1)] but also the workload of the SW tests was significantly higher in active than in inactive patients. All the inactive patients reported that they experienced the SW during walking/brisk walking in daily life, whereas active patients only reported experiencing this phenomenon during more strenuous activities (very brisk walking/jogging and bicycling).Conclusion: A higher aerobic fitness and an active lifestyle are associated with a higher workload eliciting the so-called SW phenomenon in patients with McArdle disease, which has a positive impact on their exercise tolerance during daily living. |
| first_indexed | 2024-12-21T06:15:04Z |
| format | Article |
| id | doaj.art-916e603d124a47a9a41560072c24ab0d |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-21T06:15:04Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-916e603d124a47a9a41560072c24ab0d2022-12-21T19:13:25ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-10-011210.3389/fphys.2021.744632744632The Second Wind in McArdle Patients: Fitness MattersEduardo Salazar-Martínez0Alfredo Santalla1Alfredo Santalla2Pedro L. Valenzuela3Gisela Nogales-Gadea4Tomàs Pinós5Tomàs Pinós6María Morán7María Morán8Alejandro Santos-Lozano9Alejandro Santos-Lozano10Carmen Fiuza-Luces11Alejandro Lucia12Alejandro Lucia13Centro de Estudios Universitarios Cardenal Spínola-CEU, Seville, SpainDepartment of Sports and Computing, Pablo de Olavide University, Seville, SpainEVOPRED Research Group, Universidad Europea de Canarias, Tenerife, SpainFaculty of Sport Sciences, Universidad Europea de Madrid, Madrid, SpainNeuromuscular and Neuropediatric Research Group, Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Barcelona, SpainCentre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, SpainMitochondrial and Neuromuscular Disorders Unit, Vall d’Hebron Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, SpainCentre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, SpainMitochondrial and Neuromuscular Diseases Laboratory, Instituto de Investigación Sanitaria Hospital ‘12 de Octubre’ (‘imas12’), Madrid, Spaini+HeALTH, European University Miguel de Cervantes, Valladolid, Spain0Physical Activity and Health Research Group, Instituto de Investigación Sanitaria Hospital ‘12 de Octubre’ (‘imas12’), Madrid, Spain0Physical Activity and Health Research Group, Instituto de Investigación Sanitaria Hospital ‘12 de Octubre’ (‘imas12’), Madrid, SpainFaculty of Sport Sciences, Universidad Europea de Madrid, Madrid, Spain0Physical Activity and Health Research Group, Instituto de Investigación Sanitaria Hospital ‘12 de Octubre’ (‘imas12’), Madrid, SpainBackground: The “second wind” (SW) phenomenon—commonly referring to both an initial period of marked intolerance to dynamic exercise (e.g., brisk walking) that is not followed by perceived improvement and disappearance of previous tachycardia (i.e., the actual “SW”) until 6–10 min has elapsed—is an almost unique feature of McArdle disease that limits adherence to an active lifestyle. In this regard, an increase in the workload eliciting the SW could potentially translate into an improved patients’ exercise tolerance in daily life. We aimed to determine whether aerobic fitness and physical activity (PA) levels are correlated with the minimum workload eliciting the SW in McArdle patients—as well as with the corresponding heart rate value. We also compared the SW variables and aerobic fitness indicators in inactive vs. active patients.Methods: Fifty-four McArdle patients (24 women, mean ± SD age 33 ± 12 years) performed 12-min constant-load and maximum ramp-like cycle-ergometer tests for SW detection and aerobic fitness [peak oxygen uptake (VO2peak) and workload and ventilatory threshold] determination, respectively. They were categorized as physically active/inactive during the prior 6 months (active = reporting ≥150 min/week or ≥75 min/week in moderate or vigorous-intensity aerobic PA, respectively) and were also asked on their self-report of the SW.Results: Both peak and submaximal indicators of aerobic fitness obtained in the ramp tests were significantly correlated with the workload of the SW test, with a particularly strong correlation for the VO2peak and peak workload attained by the patients (both Pearson’s coefficients > 0.70). Twenty (seven women) and 24 patients (18 women) were categorized as physically active and inactive, respectively. Not only the aerobic fitness level [∼18–19% higher values of VO2peak (ml⋅kg–1⋅min–1)] but also the workload of the SW tests was significantly higher in active than in inactive patients. All the inactive patients reported that they experienced the SW during walking/brisk walking in daily life, whereas active patients only reported experiencing this phenomenon during more strenuous activities (very brisk walking/jogging and bicycling).Conclusion: A higher aerobic fitness and an active lifestyle are associated with a higher workload eliciting the so-called SW phenomenon in patients with McArdle disease, which has a positive impact on their exercise tolerance during daily living.https://www.frontiersin.org/articles/10.3389/fphys.2021.744632/fullglycogenosis type 5myophosphorylase deficiencycardiorespiratory fitnessventilatory thresholdphysical activity second wind in McArdles 2 |
| spellingShingle | Eduardo Salazar-Martínez Alfredo Santalla Alfredo Santalla Pedro L. Valenzuela Gisela Nogales-Gadea Tomàs Pinós Tomàs Pinós María Morán María Morán Alejandro Santos-Lozano Alejandro Santos-Lozano Carmen Fiuza-Luces Alejandro Lucia Alejandro Lucia The Second Wind in McArdle Patients: Fitness Matters Frontiers in Physiology glycogenosis type 5 myophosphorylase deficiency cardiorespiratory fitness ventilatory threshold physical activity second wind in McArdles 2 |
| title | The Second Wind in McArdle Patients: Fitness Matters |
| title_full | The Second Wind in McArdle Patients: Fitness Matters |
| title_fullStr | The Second Wind in McArdle Patients: Fitness Matters |
| title_full_unstemmed | The Second Wind in McArdle Patients: Fitness Matters |
| title_short | The Second Wind in McArdle Patients: Fitness Matters |
| title_sort | second wind in mcardle patients fitness matters |
| topic | glycogenosis type 5 myophosphorylase deficiency cardiorespiratory fitness ventilatory threshold physical activity second wind in McArdles 2 |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2021.744632/full |
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