Mechanism of increased risk of insulin resistance in aging skeletal muscle
Abstract As age increases, the risk of developing type 2 diabetes increases, which is associated with senile skeletal muscle dysfunction. During skeletal muscle aging, mitochondrial dysfunction, intramyocellular lipid accumulation, increased inflammation, oxidative stress, modified activity of insul...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-02-01
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| Series: | Diabetology & Metabolic Syndrome |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13098-020-0523-x |
| _version_ | 1818957907099648000 |
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| author | Jian Shou Pei-Jie Chen Wei-Hua Xiao |
| author_facet | Jian Shou Pei-Jie Chen Wei-Hua Xiao |
| author_sort | Jian Shou |
| collection | DOAJ |
| description | Abstract As age increases, the risk of developing type 2 diabetes increases, which is associated with senile skeletal muscle dysfunction. During skeletal muscle aging, mitochondrial dysfunction, intramyocellular lipid accumulation, increased inflammation, oxidative stress, modified activity of insulin sensitivity regulatory enzymes, endoplasmic reticulum stress, decreased autophagy, sarcopenia and over-activated renin-angiotensin system may occur. These changes can impair skeletal muscle insulin sensitivity and increase the risk of insulin resistance and type 2 diabetes during skeletal muscle aging. This review of the mechanism of the increased risk of insulin resistance during skeletal muscle aging will provide a more comprehensive explanation for the increased incidence of type 2 diabetes in elderly individuals, and will also provide a more comprehensive perspective for the prevention and treatment of type 2 diabetes in elderly populations. |
| first_indexed | 2024-12-20T11:17:18Z |
| format | Article |
| id | doaj.art-916f28731a1244dcabb0f48329e1d715 |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-12-20T11:17:18Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-916f28731a1244dcabb0f48329e1d7152022-12-21T19:42:35ZengBMCDiabetology & Metabolic Syndrome1758-59962020-02-0112111010.1186/s13098-020-0523-xMechanism of increased risk of insulin resistance in aging skeletal muscleJian Shou0Pei-Jie Chen1Wei-Hua Xiao2School of Kinesiology, Shanghai University of SportSchool of Kinesiology, Shanghai University of SportSchool of Kinesiology, Shanghai University of SportAbstract As age increases, the risk of developing type 2 diabetes increases, which is associated with senile skeletal muscle dysfunction. During skeletal muscle aging, mitochondrial dysfunction, intramyocellular lipid accumulation, increased inflammation, oxidative stress, modified activity of insulin sensitivity regulatory enzymes, endoplasmic reticulum stress, decreased autophagy, sarcopenia and over-activated renin-angiotensin system may occur. These changes can impair skeletal muscle insulin sensitivity and increase the risk of insulin resistance and type 2 diabetes during skeletal muscle aging. This review of the mechanism of the increased risk of insulin resistance during skeletal muscle aging will provide a more comprehensive explanation for the increased incidence of type 2 diabetes in elderly individuals, and will also provide a more comprehensive perspective for the prevention and treatment of type 2 diabetes in elderly populations.https://doi.org/10.1186/s13098-020-0523-xSkeletal muscle agingInsulin resistanceMechanism |
| spellingShingle | Jian Shou Pei-Jie Chen Wei-Hua Xiao Mechanism of increased risk of insulin resistance in aging skeletal muscle Diabetology & Metabolic Syndrome Skeletal muscle aging Insulin resistance Mechanism |
| title | Mechanism of increased risk of insulin resistance in aging skeletal muscle |
| title_full | Mechanism of increased risk of insulin resistance in aging skeletal muscle |
| title_fullStr | Mechanism of increased risk of insulin resistance in aging skeletal muscle |
| title_full_unstemmed | Mechanism of increased risk of insulin resistance in aging skeletal muscle |
| title_short | Mechanism of increased risk of insulin resistance in aging skeletal muscle |
| title_sort | mechanism of increased risk of insulin resistance in aging skeletal muscle |
| topic | Skeletal muscle aging Insulin resistance Mechanism |
| url | https://doi.org/10.1186/s13098-020-0523-x |
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