Exploring the Differences in the Gut Microbiome in Atopic Dermatitis According to the Presence of Gastrointestinal Symptoms
(1) Background: Atopic dermatitis (AD) is a multifactorial chronic allergic skin disease. Gastrointestinal (GI) functions have been suggested to be associated with its incidence or severity. As modulators of the gut–skin axis, gut microbes might affect the pathophysiology of AD. (2) Methods: We divi...
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| Format: | Article |
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MDPI AG
2022-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/13/3690 |
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| author | Chang-Yi Han Soon-Kyeong Kwon Mijung Yeom Dae-Hyun Hahm Jae-Woo Park Hi-Joon Park Kyuseok Kim |
| author_facet | Chang-Yi Han Soon-Kyeong Kwon Mijung Yeom Dae-Hyun Hahm Jae-Woo Park Hi-Joon Park Kyuseok Kim |
| author_sort | Chang-Yi Han |
| collection | DOAJ |
| description | (1) Background: Atopic dermatitis (AD) is a multifactorial chronic allergic skin disease. Gastrointestinal (GI) functions have been suggested to be associated with its incidence or severity. As modulators of the gut–skin axis, gut microbes might affect the pathophysiology of AD. (2) Methods: We divided a cohort of patients with AD according to their GI symptoms as follows: AD with epigastric fullness (ADwEF), AD with epigastric rigidity (ADwER), and AD without GI symptoms (ADw/oGI). The gut microbial profiles were analyzed using 16S rRNA amplicon sequencing. (3) Results: The microbiota of the ADwER group showed low diversity indices in richness and evenness and formed a separate cluster to the other groups. In the ADwER group, the proportion of <i>Bacteroides</i> increased, while that of <i>Prevotella</i> decreased; functional pathways related to phosphotransferase systems were not abundant relative to those in the ADw/oGI group. Taken together, patients with AD with GI symptoms have a different microbiome from patients with simple AD. (4) Conclusions: In an exploratory study aimed at evaluating the relationship between AD and GI symptoms, the gut microbiome in patients with AD with GI symptoms differed from that in patients with simple AD, and this result could serve as a basis for further gut–skin axis studies. |
| first_indexed | 2024-03-09T04:05:44Z |
| format | Article |
| id | doaj.art-9171842069404392aa99cf2131c10f68 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T04:05:44Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-9171842069404392aa99cf2131c10f682023-12-03T14:07:40ZengMDPI AGJournal of Clinical Medicine2077-03832022-06-011113369010.3390/jcm11133690Exploring the Differences in the Gut Microbiome in Atopic Dermatitis According to the Presence of Gastrointestinal SymptomsChang-Yi Han0Soon-Kyeong Kwon1Mijung Yeom2Dae-Hyun Hahm3Jae-Woo Park4Hi-Joon Park5Kyuseok Kim6Department of Ophthalmology, Otorhinolaryngology, and Dermatology of Korean Medicine, Graduate School of Korean Medicine, Kyung Hee University, Seoul 02447, KoreaDivision of Applied Life Science (BK21), Gyeongsang National University, Jinju 52828, KoreaAcupuncture & Meridian Science Research Center, College of Korean Medicine, Kyung Hee University, Seoul 02447, KoreaAcupuncture & Meridian Science Research Center, College of Korean Medicine, Kyung Hee University, Seoul 02447, KoreaDepartment of Gastroenterology, College of Korean Medicine, Kyung Hee University, Seoul 02447, KoreaAcupuncture & Meridian Science Research Center, College of Korean Medicine, Kyung Hee University, Seoul 02447, KoreaDepartment of Ophthalmology, Otorhinolaryngology, and Dermatology of Korean Medicine, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea(1) Background: Atopic dermatitis (AD) is a multifactorial chronic allergic skin disease. Gastrointestinal (GI) functions have been suggested to be associated with its incidence or severity. As modulators of the gut–skin axis, gut microbes might affect the pathophysiology of AD. (2) Methods: We divided a cohort of patients with AD according to their GI symptoms as follows: AD with epigastric fullness (ADwEF), AD with epigastric rigidity (ADwER), and AD without GI symptoms (ADw/oGI). The gut microbial profiles were analyzed using 16S rRNA amplicon sequencing. (3) Results: The microbiota of the ADwER group showed low diversity indices in richness and evenness and formed a separate cluster to the other groups. In the ADwER group, the proportion of <i>Bacteroides</i> increased, while that of <i>Prevotella</i> decreased; functional pathways related to phosphotransferase systems were not abundant relative to those in the ADw/oGI group. Taken together, patients with AD with GI symptoms have a different microbiome from patients with simple AD. (4) Conclusions: In an exploratory study aimed at evaluating the relationship between AD and GI symptoms, the gut microbiome in patients with AD with GI symptoms differed from that in patients with simple AD, and this result could serve as a basis for further gut–skin axis studies.https://www.mdpi.com/2077-0383/11/13/3690atopic dermatitisgastrointestinal symptomsgut microbiomegut–skin axis |
| spellingShingle | Chang-Yi Han Soon-Kyeong Kwon Mijung Yeom Dae-Hyun Hahm Jae-Woo Park Hi-Joon Park Kyuseok Kim Exploring the Differences in the Gut Microbiome in Atopic Dermatitis According to the Presence of Gastrointestinal Symptoms Journal of Clinical Medicine atopic dermatitis gastrointestinal symptoms gut microbiome gut–skin axis |
| title | Exploring the Differences in the Gut Microbiome in Atopic Dermatitis According to the Presence of Gastrointestinal Symptoms |
| title_full | Exploring the Differences in the Gut Microbiome in Atopic Dermatitis According to the Presence of Gastrointestinal Symptoms |
| title_fullStr | Exploring the Differences in the Gut Microbiome in Atopic Dermatitis According to the Presence of Gastrointestinal Symptoms |
| title_full_unstemmed | Exploring the Differences in the Gut Microbiome in Atopic Dermatitis According to the Presence of Gastrointestinal Symptoms |
| title_short | Exploring the Differences in the Gut Microbiome in Atopic Dermatitis According to the Presence of Gastrointestinal Symptoms |
| title_sort | exploring the differences in the gut microbiome in atopic dermatitis according to the presence of gastrointestinal symptoms |
| topic | atopic dermatitis gastrointestinal symptoms gut microbiome gut–skin axis |
| url | https://www.mdpi.com/2077-0383/11/13/3690 |
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