Influences of gestational diabetes mellitus on the oral microbiota in offspring from birth to 1 month old
Abstract Background Maternal gestational diabetes mellitus (GDM) had long-term influences on the health of their children. However, the influences of GDM on the oral microbiota, which was closely related to oral and systemic health in offspring, were less documented. The present study aimed to explo...
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| Format: | Article |
| Language: | English |
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BMC
2022-04-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | https://doi.org/10.1186/s12884-022-04630-1 |
| _version_ | 1819060969073016832 |
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| author | Qiying Song Bin Xiao Hongli Huang Liya Ma Jian V. Zhang Yuanfang Zhu |
| author_facet | Qiying Song Bin Xiao Hongli Huang Liya Ma Jian V. Zhang Yuanfang Zhu |
| author_sort | Qiying Song |
| collection | DOAJ |
| description | Abstract Background Maternal gestational diabetes mellitus (GDM) had long-term influences on the health of their children. However, the influences of GDM on the oral microbiota, which was closely related to oral and systemic health in offspring, were less documented. The present study aimed to explore the oral microbiota of neonates born to mothers with GDM is differentially colonized compared with those born to mothers without GDM, and whether any such differences persist to 1 month of age. Methods Oral samples were collected from children of mothers with (n = 20) and without GDM (n = 34) at birth and again at an average age of 1 month. The oral microbiota was characterized by 16S rRNA sequencing (V3-V4). Differences in diversity and composition according to maternal GDM status were assessed, and different metabolic functional pathways and microbial ecological networks were also analyzed. Results Although no significant differences were observed in diversity metrics between GDM and non-GDM groups (P > 0.05), we found significant differences in the taxonomic composition of oral microbiota from phylum to genus level between the two groups, with the GDM group exhibiting less abundance of Veillonella in both “Day 1” (P < 0.001) and “Day 30” (P < 0.05) phases. Metabolic pathways analysis showed that 5-aminoimidazole ribonucleotide biosynthesis and inosine-5'-phosphate biosynthesis were enriched in GDM subjects in the “Day 30” phase. Moreover, ecological network analysis revealed apparent differences between GDM and control groups, with the non-GDM group containing more high-degree nodes and microbial interactions compared with the GDM group. Conclusion Maternal GDM was associated with an altered oral microbial composition in neonates, although the distinct difference between GDM and non-GDM groups diminished in infancy. The oral microbiota functions and ecological networks differed dramatically between the two groups, highlighting the importance of maternal GDM status on initial oral microbiota in offspring. |
| first_indexed | 2024-12-21T14:35:26Z |
| format | Article |
| id | doaj.art-9171bfd244d34af29fe0a903d6839258 |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-12-21T14:35:26Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-9171bfd244d34af29fe0a903d68392582022-12-21T19:00:21ZengBMCBMC Pregnancy and Childbirth1471-23932022-04-0122111110.1186/s12884-022-04630-1Influences of gestational diabetes mellitus on the oral microbiota in offspring from birth to 1 month oldQiying Song0Bin Xiao1Hongli Huang2Liya Ma3Jian V. Zhang4Yuanfang Zhu5Maternal-Fetal Medicine Institute, Shenzhen Baoan Women’s and Children’s Hospital, Jinan UniversityMaternal-Fetal Medicine Institute, Shenzhen Baoan Women’s and Children’s Hospital, Jinan UniversityShenzhen Luohu Maternity and Child Health Care HospitalDepartment of Child Healthcare, Shenzhen Baoan Women’s and Children’s Hospital, Jinan UniversityCenter for Energy Metabolism and Reproduction, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of SciencesMaternal-Fetal Medicine Institute, Shenzhen Baoan Women’s and Children’s Hospital, Jinan UniversityAbstract Background Maternal gestational diabetes mellitus (GDM) had long-term influences on the health of their children. However, the influences of GDM on the oral microbiota, which was closely related to oral and systemic health in offspring, were less documented. The present study aimed to explore the oral microbiota of neonates born to mothers with GDM is differentially colonized compared with those born to mothers without GDM, and whether any such differences persist to 1 month of age. Methods Oral samples were collected from children of mothers with (n = 20) and without GDM (n = 34) at birth and again at an average age of 1 month. The oral microbiota was characterized by 16S rRNA sequencing (V3-V4). Differences in diversity and composition according to maternal GDM status were assessed, and different metabolic functional pathways and microbial ecological networks were also analyzed. Results Although no significant differences were observed in diversity metrics between GDM and non-GDM groups (P > 0.05), we found significant differences in the taxonomic composition of oral microbiota from phylum to genus level between the two groups, with the GDM group exhibiting less abundance of Veillonella in both “Day 1” (P < 0.001) and “Day 30” (P < 0.05) phases. Metabolic pathways analysis showed that 5-aminoimidazole ribonucleotide biosynthesis and inosine-5'-phosphate biosynthesis were enriched in GDM subjects in the “Day 30” phase. Moreover, ecological network analysis revealed apparent differences between GDM and control groups, with the non-GDM group containing more high-degree nodes and microbial interactions compared with the GDM group. Conclusion Maternal GDM was associated with an altered oral microbial composition in neonates, although the distinct difference between GDM and non-GDM groups diminished in infancy. The oral microbiota functions and ecological networks differed dramatically between the two groups, highlighting the importance of maternal GDM status on initial oral microbiota in offspring.https://doi.org/10.1186/s12884-022-04630-1Gestational diabetes mellitusOral microbiotaInfancy16S rRNA |
| spellingShingle | Qiying Song Bin Xiao Hongli Huang Liya Ma Jian V. Zhang Yuanfang Zhu Influences of gestational diabetes mellitus on the oral microbiota in offspring from birth to 1 month old BMC Pregnancy and Childbirth Gestational diabetes mellitus Oral microbiota Infancy 16S rRNA |
| title | Influences of gestational diabetes mellitus on the oral microbiota in offspring from birth to 1 month old |
| title_full | Influences of gestational diabetes mellitus on the oral microbiota in offspring from birth to 1 month old |
| title_fullStr | Influences of gestational diabetes mellitus on the oral microbiota in offspring from birth to 1 month old |
| title_full_unstemmed | Influences of gestational diabetes mellitus on the oral microbiota in offspring from birth to 1 month old |
| title_short | Influences of gestational diabetes mellitus on the oral microbiota in offspring from birth to 1 month old |
| title_sort | influences of gestational diabetes mellitus on the oral microbiota in offspring from birth to 1 month old |
| topic | Gestational diabetes mellitus Oral microbiota Infancy 16S rRNA |
| url | https://doi.org/10.1186/s12884-022-04630-1 |
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