Polyphenolics with Strong Antioxidant Activity from <i>Acacia nilotica</i> Ameliorate Some Biochemical Signs of Arsenic-Induced Neurotoxicity and Oxidative Stress in Mice
Neurotoxicity is a serious health problem of patients chronically exposed to arsenic. There is no specific treatment of this problem. Oxidative stress has been implicated in the pathological process of neurotoxicity. Polyphenolics have proven antioxidant activity, thereby offering protection against...
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MDPI AG
2022-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/3/1037 |
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| author | Tahira Foyzun Abdullah Al Mahmud Md. Salim Ahammed Md. Imran Nur Manik Md. Kamrul Hasan KM Monirul Islam Simin Sobnom Lopa Md. Yusuf Al-Amin Kushal Biswas Mst. Rejina Afrin AHM Khurshid Alam Golam Sadik |
| author_facet | Tahira Foyzun Abdullah Al Mahmud Md. Salim Ahammed Md. Imran Nur Manik Md. Kamrul Hasan KM Monirul Islam Simin Sobnom Lopa Md. Yusuf Al-Amin Kushal Biswas Mst. Rejina Afrin AHM Khurshid Alam Golam Sadik |
| author_sort | Tahira Foyzun |
| collection | DOAJ |
| description | Neurotoxicity is a serious health problem of patients chronically exposed to arsenic. There is no specific treatment of this problem. Oxidative stress has been implicated in the pathological process of neurotoxicity. Polyphenolics have proven antioxidant activity, thereby offering protection against oxidative stress. In this study, we have isolated the polyphenolics from <i>Acacia nilotica</i> and investigated its effect against arsenic-induced neurotoxicity and oxidative stress in mice. <i>Acacia nilotica</i> polyphenolics prepared from column chromatography of the crude methanol extract using diaion resin contained a phenolic content of 452.185 ± 7.879 mg gallic acid equivalent/gm of sample and flavonoid content of 200.075 ± 0.755 mg catechin equivalent/gm of sample. The polyphenolics exhibited potent antioxidant activity with respect to free radical scavenging ability, total antioxidant activity and inhibition of lipid peroxidation. Administration of arsenic in mice showed a reduction of acetylcholinesterase activity in the brain which was counteracted by <i>Acacia nilotica</i> polyphenolics. Similarly, elevation of lipid peroxidation and depletion of glutathione in the brain of mice was effectively restored to normal level by <i>Acacia nilotica</i> polyphenolics. Gallic acid methyl ester, catechin and catechin-7-gallate were identified in the polyphenolics as the major active compounds. These results suggest that <i>Acacia nilotica</i> polyphenolics due to its strong antioxidant potential might be effective in the management of arsenic induced neurotoxicity. |
| first_indexed | 2024-03-09T23:27:27Z |
| format | Article |
| id | doaj.art-91727766fe044c4fb2c02eaacb01f41e |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T23:27:27Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-91727766fe044c4fb2c02eaacb01f41e2023-11-23T17:16:35ZengMDPI AGMolecules1420-30492022-02-01273103710.3390/molecules27031037Polyphenolics with Strong Antioxidant Activity from <i>Acacia nilotica</i> Ameliorate Some Biochemical Signs of Arsenic-Induced Neurotoxicity and Oxidative Stress in MiceTahira Foyzun0Abdullah Al Mahmud1Md. Salim Ahammed2Md. Imran Nur Manik3Md. Kamrul Hasan4KM Monirul Islam5Simin Sobnom Lopa6Md. Yusuf Al-Amin7Kushal Biswas8Mst. Rejina Afrin9AHM Khurshid Alam10Golam Sadik11Department of Pharmacy, Southeast University, Dhaka 1212, BangladeshDepartment of Pharmacy, University of Rajshahi, Rajshahi 6205, BangladeshDepartment of Pharmacy, University of Rajshahi, Rajshahi 6205, BangladeshDepartment of Pharmacy, Northern University Bangladesh, Dhaka 1205, BangladeshDepartment of Pharmacy, Comilla University, Kotbari, Cumilla 3506, BangladeshDepartment of Pharmacy, University of Rajshahi, Rajshahi 6205, BangladeshDepartment of Pharmacy, University of Rajshahi, Rajshahi 6205, BangladeshDepartment of Pharmacy, University of Rajshahi, Rajshahi 6205, BangladeshDepartment of Pharmacy, East West University, Dhaka 1212, BangladeshDepartment of Pharmacy, East West University, Dhaka 1212, BangladeshDepartment of Pharmacy, University of Rajshahi, Rajshahi 6205, BangladeshDepartment of Pharmacy, University of Rajshahi, Rajshahi 6205, BangladeshNeurotoxicity is a serious health problem of patients chronically exposed to arsenic. There is no specific treatment of this problem. Oxidative stress has been implicated in the pathological process of neurotoxicity. Polyphenolics have proven antioxidant activity, thereby offering protection against oxidative stress. In this study, we have isolated the polyphenolics from <i>Acacia nilotica</i> and investigated its effect against arsenic-induced neurotoxicity and oxidative stress in mice. <i>Acacia nilotica</i> polyphenolics prepared from column chromatography of the crude methanol extract using diaion resin contained a phenolic content of 452.185 ± 7.879 mg gallic acid equivalent/gm of sample and flavonoid content of 200.075 ± 0.755 mg catechin equivalent/gm of sample. The polyphenolics exhibited potent antioxidant activity with respect to free radical scavenging ability, total antioxidant activity and inhibition of lipid peroxidation. Administration of arsenic in mice showed a reduction of acetylcholinesterase activity in the brain which was counteracted by <i>Acacia nilotica</i> polyphenolics. Similarly, elevation of lipid peroxidation and depletion of glutathione in the brain of mice was effectively restored to normal level by <i>Acacia nilotica</i> polyphenolics. Gallic acid methyl ester, catechin and catechin-7-gallate were identified in the polyphenolics as the major active compounds. These results suggest that <i>Acacia nilotica</i> polyphenolics due to its strong antioxidant potential might be effective in the management of arsenic induced neurotoxicity.https://www.mdpi.com/1420-3049/27/3/1037arsenicneurotoxicitybiomarker<i>Acacia nilotica</i>phenolicsflavonoids |
| spellingShingle | Tahira Foyzun Abdullah Al Mahmud Md. Salim Ahammed Md. Imran Nur Manik Md. Kamrul Hasan KM Monirul Islam Simin Sobnom Lopa Md. Yusuf Al-Amin Kushal Biswas Mst. Rejina Afrin AHM Khurshid Alam Golam Sadik Polyphenolics with Strong Antioxidant Activity from <i>Acacia nilotica</i> Ameliorate Some Biochemical Signs of Arsenic-Induced Neurotoxicity and Oxidative Stress in Mice Molecules arsenic neurotoxicity biomarker <i>Acacia nilotica</i> phenolics flavonoids |
| title | Polyphenolics with Strong Antioxidant Activity from <i>Acacia nilotica</i> Ameliorate Some Biochemical Signs of Arsenic-Induced Neurotoxicity and Oxidative Stress in Mice |
| title_full | Polyphenolics with Strong Antioxidant Activity from <i>Acacia nilotica</i> Ameliorate Some Biochemical Signs of Arsenic-Induced Neurotoxicity and Oxidative Stress in Mice |
| title_fullStr | Polyphenolics with Strong Antioxidant Activity from <i>Acacia nilotica</i> Ameliorate Some Biochemical Signs of Arsenic-Induced Neurotoxicity and Oxidative Stress in Mice |
| title_full_unstemmed | Polyphenolics with Strong Antioxidant Activity from <i>Acacia nilotica</i> Ameliorate Some Biochemical Signs of Arsenic-Induced Neurotoxicity and Oxidative Stress in Mice |
| title_short | Polyphenolics with Strong Antioxidant Activity from <i>Acacia nilotica</i> Ameliorate Some Biochemical Signs of Arsenic-Induced Neurotoxicity and Oxidative Stress in Mice |
| title_sort | polyphenolics with strong antioxidant activity from i acacia nilotica i ameliorate some biochemical signs of arsenic induced neurotoxicity and oxidative stress in mice |
| topic | arsenic neurotoxicity biomarker <i>Acacia nilotica</i> phenolics flavonoids |
| url | https://www.mdpi.com/1420-3049/27/3/1037 |
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