Radioembolization-Induced Changes in Hepatic [<sup>18</sup>F]FDG Metabolism in Non-Tumorous Liver Parenchyma
Background: [<sup>18</sup>F]FDG-PET/CT is increasingly used for response assessments after oncologic treatment. The known response criteria for [<sup>18</sup>F]FDG-PET/CT use healthy liver parenchyma as the reference standard. However, the [<sup>18</sup>F]FDG live...
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MDPI AG
2022-10-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/10/2518 |
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| author | Manon N. Braat Caren van Roekel Marnix G. Lam Arthur J. Braat |
| author_facet | Manon N. Braat Caren van Roekel Marnix G. Lam Arthur J. Braat |
| author_sort | Manon N. Braat |
| collection | DOAJ |
| description | Background: [<sup>18</sup>F]FDG-PET/CT is increasingly used for response assessments after oncologic treatment. The known response criteria for [<sup>18</sup>F]FDG-PET/CT use healthy liver parenchyma as the reference standard. However, the [<sup>18</sup>F]FDG liver metabolism results may change as a result of the given therapy. The aim of this study was to assess changes in [<sup>18</sup>F]FDG liver metabolism after hepatic <sup>90</sup>Y resin radioembolization. Methods: [<sup>18</sup>F]FDG-PET/CT scans prior to radioembolization and one and three months after radioembolization (consistent with the PERCIST comparability criteria), as well as <sup>90</sup>Y-PET/CT scans, were analyzed using 3 cm VOIs. The FDG activity concentration and absorbed dose were measured. A linear mixed-effects logistic regression model and logistic mixed-effects model were used to assess the correlation between the FDG-activity concentration, absorbed dose, and biochemical changes. Results: The median SUL<sub>VOI,liver</sub> at baseline was 1.8 (range = 1.2–2.8). The mean change in SUL<sub>VOI,liver</sub> per month with an increase in time was 0.05 (95%CI 0.02–0.09) at <i>p</i> < 0.001. The median absorbed dose per VOI was 31.3 Gy (range = 0.1–82.3 Gy). The mean percent change in ΔSUL<sub>VOI,liver</sub> for every Gy increase in the absorbed dose was –0.04 (95%CI −0.22–0.14) at <i>p</i> = 0.67. The SUL<sub>blood</sub> and SUL<sub>spleen</sub> results showed no increase. Conclusions: The [<sup>18</sup>F]FDG metabolism in the normal liver parenchyma is significantly but mildly increased after radioembolization, which can interfere with its use as a threshold for therapy response. |
| first_indexed | 2024-03-09T20:21:30Z |
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| id | doaj.art-9174e7cf855f44f9b4fa2d186b55a880 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T20:21:30Z |
| publishDate | 2022-10-01 |
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| series | Diagnostics |
| spelling | doaj.art-9174e7cf855f44f9b4fa2d186b55a8802023-11-23T23:46:41ZengMDPI AGDiagnostics2075-44182022-10-011210251810.3390/diagnostics12102518Radioembolization-Induced Changes in Hepatic [<sup>18</sup>F]FDG Metabolism in Non-Tumorous Liver ParenchymaManon N. Braat0Caren van Roekel1Marnix G. Lam2Arthur J. Braat3Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The NetherlandsDepartment of Radiology and Nuclear Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The NetherlandsDepartment of Radiology and Nuclear Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The NetherlandsDepartment of Radiology and Nuclear Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The NetherlandsBackground: [<sup>18</sup>F]FDG-PET/CT is increasingly used for response assessments after oncologic treatment. The known response criteria for [<sup>18</sup>F]FDG-PET/CT use healthy liver parenchyma as the reference standard. However, the [<sup>18</sup>F]FDG liver metabolism results may change as a result of the given therapy. The aim of this study was to assess changes in [<sup>18</sup>F]FDG liver metabolism after hepatic <sup>90</sup>Y resin radioembolization. Methods: [<sup>18</sup>F]FDG-PET/CT scans prior to radioembolization and one and three months after radioembolization (consistent with the PERCIST comparability criteria), as well as <sup>90</sup>Y-PET/CT scans, were analyzed using 3 cm VOIs. The FDG activity concentration and absorbed dose were measured. A linear mixed-effects logistic regression model and logistic mixed-effects model were used to assess the correlation between the FDG-activity concentration, absorbed dose, and biochemical changes. Results: The median SUL<sub>VOI,liver</sub> at baseline was 1.8 (range = 1.2–2.8). The mean change in SUL<sub>VOI,liver</sub> per month with an increase in time was 0.05 (95%CI 0.02–0.09) at <i>p</i> < 0.001. The median absorbed dose per VOI was 31.3 Gy (range = 0.1–82.3 Gy). The mean percent change in ΔSUL<sub>VOI,liver</sub> for every Gy increase in the absorbed dose was –0.04 (95%CI −0.22–0.14) at <i>p</i> = 0.67. The SUL<sub>blood</sub> and SUL<sub>spleen</sub> results showed no increase. Conclusions: The [<sup>18</sup>F]FDG metabolism in the normal liver parenchyma is significantly but mildly increased after radioembolization, which can interfere with its use as a threshold for therapy response.https://www.mdpi.com/2075-4418/12/10/2518FDG-PETradioembolizationSIRTPERCIST |
| spellingShingle | Manon N. Braat Caren van Roekel Marnix G. Lam Arthur J. Braat Radioembolization-Induced Changes in Hepatic [<sup>18</sup>F]FDG Metabolism in Non-Tumorous Liver Parenchyma Diagnostics FDG-PET radioembolization SIRT PERCIST |
| title | Radioembolization-Induced Changes in Hepatic [<sup>18</sup>F]FDG Metabolism in Non-Tumorous Liver Parenchyma |
| title_full | Radioembolization-Induced Changes in Hepatic [<sup>18</sup>F]FDG Metabolism in Non-Tumorous Liver Parenchyma |
| title_fullStr | Radioembolization-Induced Changes in Hepatic [<sup>18</sup>F]FDG Metabolism in Non-Tumorous Liver Parenchyma |
| title_full_unstemmed | Radioembolization-Induced Changes in Hepatic [<sup>18</sup>F]FDG Metabolism in Non-Tumorous Liver Parenchyma |
| title_short | Radioembolization-Induced Changes in Hepatic [<sup>18</sup>F]FDG Metabolism in Non-Tumorous Liver Parenchyma |
| title_sort | radioembolization induced changes in hepatic sup 18 sup f fdg metabolism in non tumorous liver parenchyma |
| topic | FDG-PET radioembolization SIRT PERCIST |
| url | https://www.mdpi.com/2075-4418/12/10/2518 |
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