SENP3 deletion promotes M2 macrophage polarization and accelerates wound healing through smad6/IκB/p65 signaling pathway

SENP3 deletion promotes M2 macrophage polarization and accelerates wound healing through smad6/IκB/p65 signaling pathway

Macrophages preferentially polarize to the anti-inflammatory M2 subtype in response to alterations in the wound microenvironment. SUMO-specific protease 3 (SENP3), a SUMO-specific protease, has been proven to regulate inflammation in macrophages by deSUMOylating substrate proteins, but its contribut...

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Bibliographic Details
Main Authors: Yiwen Ma, Jiateng Hu, Xingjuan Xue, Jianmin Gu, Yuyan Pan, Jun Yang
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Heliyon
Subjects:
SENP3
Macrophage polarization
Inflammatory response
Wound healing
Smad6/IκB/p65 signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023027913

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http://www.sciencedirect.com/science/article/pii/S2405844023027913

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