Cyclodextrin-assisted synthesis of tailored mesoporous silica nanoparticles
Mesoporous silica nanoparticles (MSNs) have sparked considerable interest in drug/gene delivery, catalysis, adsorption, separation, sensing, antireflection coatings and bioimaging because of their tunable structural properties. The shape, size and pore structure of MSNs are greatly influenced by the...
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2018-02-01
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| Series: | Beilstein Journal of Nanotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjnano.9.64 |
| _version_ | 1818525249332838400 |
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| author | Fuat Topuz Tamer Uyar |
| author_facet | Fuat Topuz Tamer Uyar |
| author_sort | Fuat Topuz |
| collection | DOAJ |
| description | Mesoporous silica nanoparticles (MSNs) have sparked considerable interest in drug/gene delivery, catalysis, adsorption, separation, sensing, antireflection coatings and bioimaging because of their tunable structural properties. The shape, size and pore structure of MSNs are greatly influenced by the type of additives used, e.g., solvent and pore-templating agent. Here, we studied the influence of cyclodextrin (CD) molecules on the formation of MSNs. The nanoparticles over 100 nm in diameter were synthesized by surfactant-templated, hydrolysis–polycondensation reactions in the presence of pristine CD (β-CD) or hydroxypropyl-functionalized CDs (HP-γ-CD and HP-β-CD). Depending on the formulation conditions, differently shaped MSNs, such as bean-like, spherical, ellipsoid, aggregate and faceted were generated. The morphology and size of MSNs varied with the CD-type used. Generally, spherical particles were obtained with β-CD, while a faceted morphology was observed for the particles synthesized using HP-CDs. The particle size could be tuned by adjusting the amount of CD used; increasing the CD concentration led to larger particles. MSNs synthesized in the presence of β-CD displayed a smaller particle size than those produced with HP-functional CDs. FTIR, TGA and solid-state 13C NMR demonstrated the adsorption of CDs on the particle surfaces. The proposed concept allows for the synthesis of silica nanoparticles with control over particle shape and size by adjusting the concentration of additives in a simple, one-pot reaction system for a wide range of applications. |
| first_indexed | 2024-12-11T06:06:59Z |
| format | Article |
| id | doaj.art-9176ad9539654247917502b789d4ad6e |
| institution | Directory Open Access Journal |
| issn | 2190-4286 |
| language | English |
| last_indexed | 2024-12-11T06:06:59Z |
| publishDate | 2018-02-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Nanotechnology |
| spelling | doaj.art-9176ad9539654247917502b789d4ad6e2022-12-22T01:18:16ZengBeilstein-InstitutBeilstein Journal of Nanotechnology2190-42862018-02-019169370310.3762/bjnano.9.642190-4286-9-64Cyclodextrin-assisted synthesis of tailored mesoporous silica nanoparticlesFuat Topuz0Tamer Uyar1UNAM-National Nanotechnology Research Center, Bilkent University, 06800 Ankara, TurkeyUNAM-National Nanotechnology Research Center, Bilkent University, 06800 Ankara, TurkeyMesoporous silica nanoparticles (MSNs) have sparked considerable interest in drug/gene delivery, catalysis, adsorption, separation, sensing, antireflection coatings and bioimaging because of their tunable structural properties. The shape, size and pore structure of MSNs are greatly influenced by the type of additives used, e.g., solvent and pore-templating agent. Here, we studied the influence of cyclodextrin (CD) molecules on the formation of MSNs. The nanoparticles over 100 nm in diameter were synthesized by surfactant-templated, hydrolysis–polycondensation reactions in the presence of pristine CD (β-CD) or hydroxypropyl-functionalized CDs (HP-γ-CD and HP-β-CD). Depending on the formulation conditions, differently shaped MSNs, such as bean-like, spherical, ellipsoid, aggregate and faceted were generated. The morphology and size of MSNs varied with the CD-type used. Generally, spherical particles were obtained with β-CD, while a faceted morphology was observed for the particles synthesized using HP-CDs. The particle size could be tuned by adjusting the amount of CD used; increasing the CD concentration led to larger particles. MSNs synthesized in the presence of β-CD displayed a smaller particle size than those produced with HP-functional CDs. FTIR, TGA and solid-state 13C NMR demonstrated the adsorption of CDs on the particle surfaces. The proposed concept allows for the synthesis of silica nanoparticles with control over particle shape and size by adjusting the concentration of additives in a simple, one-pot reaction system for a wide range of applications.https://doi.org/10.3762/bjnano.9.64cyclodextrinfaceted particlesmesoporous silica nanoparticles (MSN)microporous |
| spellingShingle | Fuat Topuz Tamer Uyar Cyclodextrin-assisted synthesis of tailored mesoporous silica nanoparticles Beilstein Journal of Nanotechnology cyclodextrin faceted particles mesoporous silica nanoparticles (MSN) microporous |
| title | Cyclodextrin-assisted synthesis of tailored mesoporous silica nanoparticles |
| title_full | Cyclodextrin-assisted synthesis of tailored mesoporous silica nanoparticles |
| title_fullStr | Cyclodextrin-assisted synthesis of tailored mesoporous silica nanoparticles |
| title_full_unstemmed | Cyclodextrin-assisted synthesis of tailored mesoporous silica nanoparticles |
| title_short | Cyclodextrin-assisted synthesis of tailored mesoporous silica nanoparticles |
| title_sort | cyclodextrin assisted synthesis of tailored mesoporous silica nanoparticles |
| topic | cyclodextrin faceted particles mesoporous silica nanoparticles (MSN) microporous |
| url | https://doi.org/10.3762/bjnano.9.64 |
| work_keys_str_mv | AT fuattopuz cyclodextrinassistedsynthesisoftailoredmesoporoussilicananoparticles AT tameruyar cyclodextrinassistedsynthesisoftailoredmesoporoussilicananoparticles |