Optimized Encapsulation of the FLAP/PGES-1 Inhibitor BRP-187 in PVA-Stabilized PLGA Nanoparticles Using Microfluidics

Optimized Encapsulation of the FLAP/PGES-1 Inhibitor BRP-187 in PVA-Stabilized PLGA Nanoparticles Using Microfluidics

The dual inhibitor of the 5-lipoxygenase-activating protein (FLAP) and the microsomal prostaglandin E<sub>2</sub> synthase-1 (mPGES-1), named BRP-187, represents a promising drug candidate due to its improved anti-inflammatory efficacy along with potentially reduced side effects in compa...

Full description

Bibliographic Details
Main Authors: Mira Behnke, Antje Vollrath, Lea Klepsch, Baerbel Beringer-Siemers, Steffi Stumpf, Justyna A. Czaplewska, Stephanie Hoeppener, Oliver Werz, Ulrich S. Schubert
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Polymers
Subjects:
BRP-187
FLAP inhibitor
mPGES-1 inhibitor
PLGA nanoparticles
microfluidic
staggered herringbone mixer
Online Access:https://www.mdpi.com/2073-4360/12/11/2751

Similar Items

Similar Items