Impact of layered non-pharmacological interventions on COVID-19 transmission dynamics in Yucatan, Mexico
Background: The pandemic propagation of SARS-CoV-2 led to the adoption of a myriad of non-pharmacological interventions (NPIs, e.g., social distancing, mobility restrictions, gathering restrictions) in the Americas. Using national epidemiological data, here we report the impact of the layered adopti...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Preventive Medicine Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211335522001504 |
| _version_ | 1811296510893096960 |
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| author | G. Ayora-Talavera P. Granja-Perez M. Sauri-Vivas C.I. Hernández-Fuentes I.P. Hennessee I. López-Martínez G. Barrera-Badillo A. Che-Mendoza P. Manrique-Saide J.A. Clennon H. Gómez-Dantés G. Vazquez-Prokopec |
| author_facet | G. Ayora-Talavera P. Granja-Perez M. Sauri-Vivas C.I. Hernández-Fuentes I.P. Hennessee I. López-Martínez G. Barrera-Badillo A. Che-Mendoza P. Manrique-Saide J.A. Clennon H. Gómez-Dantés G. Vazquez-Prokopec |
| author_sort | G. Ayora-Talavera |
| collection | DOAJ |
| description | Background: The pandemic propagation of SARS-CoV-2 led to the adoption of a myriad of non-pharmacological interventions (NPIs, e.g., social distancing, mobility restrictions, gathering restrictions) in the Americas. Using national epidemiological data, here we report the impact of the layered adoption of multiple NPIs aimed at curving SARS-CoV-2 transmission in Yucatan State, Mexico. Methods: Data from suspected and laboratory confirmed COVID-19 cases during 2020 were analyzed by age groups and sex, clinical signs, and symptoms as well as outcome. The impact of NPIs was quantified using time-varying reproduction numbers (Rt) estimated as a time-series and by sectors of the city. Findings: A total of 69,602 suspected cases were reported, 39.3% were laboratory-confirmed. Men were hospitalized (60.2%), more severely ill (3% vs 1.9%) and more likely to die (62%) than women. Early in the outbreak, all sectors in Merida had Rt estimates above unity. Once all NPÍs were in place, Rt values were dramatically reduced below one, and in the last interval transmission estimates of Rt remained below one in all sectors. Interpretation: In the absence of a COVID-19 vaccination program, the combination and wide adherence of NPÍs led to a low and stable trend in SARS-CoV-2 transmission that did not overwhelm the health sector. Our study reflects that a controlled and planned ease of restrictions to balance health, social and economic recovery resulted in a single wave of transmission that prolonged at low and stable levels. Funding: GVP received funding from Emory University via the MP3 Initiative. |
| first_indexed | 2024-04-13T05:50:27Z |
| format | Article |
| id | doaj.art-9177ca82f4104e66bc97455d601a08d2 |
| institution | Directory Open Access Journal |
| issn | 2211-3355 |
| language | English |
| last_indexed | 2024-04-13T05:50:27Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Preventive Medicine Reports |
| spelling | doaj.art-9177ca82f4104e66bc97455d601a08d22022-12-22T02:59:49ZengElsevierPreventive Medicine Reports2211-33552022-08-0128101843Impact of layered non-pharmacological interventions on COVID-19 transmission dynamics in Yucatan, MexicoG. Ayora-Talavera0P. Granja-Perez1M. Sauri-Vivas2C.I. Hernández-Fuentes3I.P. Hennessee4I. López-Martínez5G. Barrera-Badillo6A. Che-Mendoza7P. Manrique-Saide8J.A. Clennon9H. Gómez-Dantés10G. Vazquez-Prokopec11Laboratorio de Virología, Centro de Investigaciones Regionales “Dr. Hideyo Noguchi”, Universidad Autónoma de Yucatán, Mérida, MexicoLaboratorio Estatal de Salud Pública, Servicios de Salud de Yucatán, Mérida, MexicoServicios de Salud de Yucatán, Mérida, MexicoServicios de Salud de Yucatán, Mérida, MexicoDepartment of Environmental Health. Rollins School of Public Health. Emory University. Atlanta, GA, USAInstituto de Referencia y Diagnóstico Epidemiológicos (InDRE), Secretaría de Salud, México, DF, MexicoInstituto de Referencia y Diagnóstico Epidemiológicos (InDRE), Secretaría de Salud, México, DF, MexicoCampus de Ciencias Biológicas y Agropecuarias, Universidad Autónoma de Yucatán, Mérida, MexicoCampus de Ciencias Biológicas y Agropecuarias, Universidad Autónoma de Yucatán, Mérida, MexicoDepartment of Environmental Sciences, Emory University, Atlanta, GA, USACenter for Health Systems Research National Institute of Public Health, Cuernavaca, MexicoDepartment of Environmental Health. Rollins School of Public Health. Emory University. Atlanta, GA, USA; Corresponding author.Background: The pandemic propagation of SARS-CoV-2 led to the adoption of a myriad of non-pharmacological interventions (NPIs, e.g., social distancing, mobility restrictions, gathering restrictions) in the Americas. Using national epidemiological data, here we report the impact of the layered adoption of multiple NPIs aimed at curving SARS-CoV-2 transmission in Yucatan State, Mexico. Methods: Data from suspected and laboratory confirmed COVID-19 cases during 2020 were analyzed by age groups and sex, clinical signs, and symptoms as well as outcome. The impact of NPIs was quantified using time-varying reproduction numbers (Rt) estimated as a time-series and by sectors of the city. Findings: A total of 69,602 suspected cases were reported, 39.3% were laboratory-confirmed. Men were hospitalized (60.2%), more severely ill (3% vs 1.9%) and more likely to die (62%) than women. Early in the outbreak, all sectors in Merida had Rt estimates above unity. Once all NPÍs were in place, Rt values were dramatically reduced below one, and in the last interval transmission estimates of Rt remained below one in all sectors. Interpretation: In the absence of a COVID-19 vaccination program, the combination and wide adherence of NPÍs led to a low and stable trend in SARS-CoV-2 transmission that did not overwhelm the health sector. Our study reflects that a controlled and planned ease of restrictions to balance health, social and economic recovery resulted in a single wave of transmission that prolonged at low and stable levels. Funding: GVP received funding from Emory University via the MP3 Initiative.http://www.sciencedirect.com/science/article/pii/S2211335522001504Non-Pharmacological InterventionsCOVID-19YucatanMexico |
| spellingShingle | G. Ayora-Talavera P. Granja-Perez M. Sauri-Vivas C.I. Hernández-Fuentes I.P. Hennessee I. López-Martínez G. Barrera-Badillo A. Che-Mendoza P. Manrique-Saide J.A. Clennon H. Gómez-Dantés G. Vazquez-Prokopec Impact of layered non-pharmacological interventions on COVID-19 transmission dynamics in Yucatan, Mexico Preventive Medicine Reports Non-Pharmacological Interventions COVID-19 Yucatan Mexico |
| title | Impact of layered non-pharmacological interventions on COVID-19 transmission dynamics in Yucatan, Mexico |
| title_full | Impact of layered non-pharmacological interventions on COVID-19 transmission dynamics in Yucatan, Mexico |
| title_fullStr | Impact of layered non-pharmacological interventions on COVID-19 transmission dynamics in Yucatan, Mexico |
| title_full_unstemmed | Impact of layered non-pharmacological interventions on COVID-19 transmission dynamics in Yucatan, Mexico |
| title_short | Impact of layered non-pharmacological interventions on COVID-19 transmission dynamics in Yucatan, Mexico |
| title_sort | impact of layered non pharmacological interventions on covid 19 transmission dynamics in yucatan mexico |
| topic | Non-Pharmacological Interventions COVID-19 Yucatan Mexico |
| url | http://www.sciencedirect.com/science/article/pii/S2211335522001504 |
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