IL-6 from cerebrospinal fluid causes widespread pain via STAT3-mediated astrocytosis in chronic constriction injury of the infraorbital nerve

IL-6 from cerebrospinal fluid causes widespread pain via STAT3-mediated astrocytosis in chronic constriction injury of the infraorbital nerve

Abstract Background The spinal inflammatory signal often spreads to distant segments, accompanied by widespread pain symptom under neuropathological conditions. Multiple cytokines are released into the cerebrospinal fluid (CSF), potentially inducing the activation of an inflammatory cascade at remot...

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Bibliographic Details
Main Authors: Ning Yu, Huan Cui, Sixuan Jin, Penghao Liu, Yehong Fang, Fengrun Sun, Yan Cao, Bo Yuan, Yikuan Xie, Wanru Duan, Chao Ma
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Journal of Neuroinflammation
Subjects:
Widespread pain
Cerebrospinal fluid
Interleukin-6
Astrocyte
Signal transducer and activator of transcription 3
Online Access:https://doi.org/10.1186/s12974-024-03049-z

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