Complete genome characterization of foot-and-mouth disease virus My-466 belonging to the novel lineage O/ME-SA/SA-2018
Foot-and-mouth disease virus (FMDV), the causative agent of the foot-and-mouth disease of cattle population possesses a rapid evolutionary rate. In Bangladesh, the first circulation of the O/ME-SA/SA-2018 lineage as a novel sublineage, MYMBD21 was reported from our laboratory. The first whole genome...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024027476 |
| _version_ | 1827316476509421568 |
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| author | Humaira Anjume Kazi Alamgir Hossain Anamica Hossain M. Anwar Hossain Munawar Sultana |
| author_facet | Humaira Anjume Kazi Alamgir Hossain Anamica Hossain M. Anwar Hossain Munawar Sultana |
| author_sort | Humaira Anjume |
| collection | DOAJ |
| description | Foot-and-mouth disease virus (FMDV), the causative agent of the foot-and-mouth disease of cattle population possesses a rapid evolutionary rate. In Bangladesh, the first circulation of the O/ME-SA/SA-2018 lineage as a novel sublineage, MYMBD21 was reported from our laboratory. The first whole genome sequence of an isolate, BAN/MY/My-466/2021 (shortly named My-466) of the SA-2018 lineage is characterized and represented in this study. The genome is 8216 nucleotides long with 6996 nucleotides open reading frame flanked by 5ꞌ UTR (1–1100) and 3ꞌ UTR (8097–8216). VP1 was found to be highly variable among the structural proteins with crucial mutations in the major antigenic region, G-H loop. Structural variations of the VP1 against both field and proposed local vaccine strains were evidenced by the G-H loop displacement in a superimposed 3D model. The complete genome information of the isolate would be valuable for undertaking proper control measures needed to limit the spread of the newly emerged FMDV strain. |
| first_indexed | 2024-03-07T14:29:13Z |
| format | Article |
| id | doaj.art-9179909cb65c43cb81267f3d4b5fbe6f |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T23:16:22Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-9179909cb65c43cb81267f3d4b5fbe6f2024-03-17T07:56:04ZengElsevierHeliyon2405-84402024-03-01105e26716Complete genome characterization of foot-and-mouth disease virus My-466 belonging to the novel lineage O/ME-SA/SA-2018Humaira Anjume0Kazi Alamgir Hossain1Anamica Hossain2M. Anwar Hossain3Munawar Sultana4Department of Microbiology, University of Dhaka, Dhaka, 1000, BangladeshDepartment of Microbiology, University of Dhaka, Dhaka, 1000, BangladeshDepartment of Microbiology, University of Dhaka, Dhaka, 1000, BangladeshDepartment of Microbiology, University of Dhaka, Dhaka, 1000, BangladeshCorresponding author. Department of Microbiology, University of Dhaka, Bangladesh.; Department of Microbiology, University of Dhaka, Dhaka, 1000, BangladeshFoot-and-mouth disease virus (FMDV), the causative agent of the foot-and-mouth disease of cattle population possesses a rapid evolutionary rate. In Bangladesh, the first circulation of the O/ME-SA/SA-2018 lineage as a novel sublineage, MYMBD21 was reported from our laboratory. The first whole genome sequence of an isolate, BAN/MY/My-466/2021 (shortly named My-466) of the SA-2018 lineage is characterized and represented in this study. The genome is 8216 nucleotides long with 6996 nucleotides open reading frame flanked by 5ꞌ UTR (1–1100) and 3ꞌ UTR (8097–8216). VP1 was found to be highly variable among the structural proteins with crucial mutations in the major antigenic region, G-H loop. Structural variations of the VP1 against both field and proposed local vaccine strains were evidenced by the G-H loop displacement in a superimposed 3D model. The complete genome information of the isolate would be valuable for undertaking proper control measures needed to limit the spread of the newly emerged FMDV strain.http://www.sciencedirect.com/science/article/pii/S2405844024027476Foot-and-mouth disease (FMD)Foot-and-mouth disease virus (FMDV)O/ME-SA/SA-2018Novel sublineageFirst complete genome |
| spellingShingle | Humaira Anjume Kazi Alamgir Hossain Anamica Hossain M. Anwar Hossain Munawar Sultana Complete genome characterization of foot-and-mouth disease virus My-466 belonging to the novel lineage O/ME-SA/SA-2018 Heliyon Foot-and-mouth disease (FMD) Foot-and-mouth disease virus (FMDV) O/ME-SA/SA-2018 Novel sublineage First complete genome |
| title | Complete genome characterization of foot-and-mouth disease virus My-466 belonging to the novel lineage O/ME-SA/SA-2018 |
| title_full | Complete genome characterization of foot-and-mouth disease virus My-466 belonging to the novel lineage O/ME-SA/SA-2018 |
| title_fullStr | Complete genome characterization of foot-and-mouth disease virus My-466 belonging to the novel lineage O/ME-SA/SA-2018 |
| title_full_unstemmed | Complete genome characterization of foot-and-mouth disease virus My-466 belonging to the novel lineage O/ME-SA/SA-2018 |
| title_short | Complete genome characterization of foot-and-mouth disease virus My-466 belonging to the novel lineage O/ME-SA/SA-2018 |
| title_sort | complete genome characterization of foot and mouth disease virus my 466 belonging to the novel lineage o me sa sa 2018 |
| topic | Foot-and-mouth disease (FMD) Foot-and-mouth disease virus (FMDV) O/ME-SA/SA-2018 Novel sublineage First complete genome |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024027476 |
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