Disease-Associated Regulation of Non-Coding RNAs by Resveratrol: Molecular Insights and Therapeutic Applications
There have been significant advances, particularly over the last 20 years, in the identification of non-coding RNAs (ncRNAs) and their pathophysiological role in a wide range of disease states, particularly cancer and other chronic conditions characterized by excess inflammation and oxidative stress...
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| Format: | Article |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.894305/full |
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| author | Roberta Giordo Zena Wehbe Anna Maria Posadino Gian Luca Erre Ali H. Eid Arduino A. Mangoni Arduino A. Mangoni Gianfranco Pintus Gianfranco Pintus |
| author_facet | Roberta Giordo Zena Wehbe Anna Maria Posadino Gian Luca Erre Ali H. Eid Arduino A. Mangoni Arduino A. Mangoni Gianfranco Pintus Gianfranco Pintus |
| author_sort | Roberta Giordo |
| collection | DOAJ |
| description | There have been significant advances, particularly over the last 20 years, in the identification of non-coding RNAs (ncRNAs) and their pathophysiological role in a wide range of disease states, particularly cancer and other chronic conditions characterized by excess inflammation and oxidative stress such as atherosclerosis, diabetes, obesity, multiple sclerosis, osteoporosis, liver and lung fibrosis. Such discoveries have potential therapeutic implications as a better understanding of the molecular mechanisms underpinning the effects of ncRNAs on critical homeostatic control mechanisms and biochemical pathways might lead to the identification of novel druggable targets. In this context, increasing evidence suggests that several natural compounds can target ncRNAs at different levels and, consequently, influence processes involved in the onset and progression of disease states. The natural phenol resveratrol has been extensively studied for therapeutic purposes in view of its established anti-inflammatory and antioxidant effects, particularly in disease states such as cancer and cardiovascular disease that are associated with human aging. However, increasing in vitro and in vivo evidence also suggests that resveratrol can directly target various ncRNAs and that this mediates, at least in part, its potential therapeutic effects. This review critically appraises the available evidence regarding the resveratrol-mediated modulation of different ncRNAs in a wide range of disease states characterized by a pro-inflammatory state and oxidative stress, the potential therapeutic applications, and future research directions. |
| first_indexed | 2024-12-11T01:05:01Z |
| format | Article |
| id | doaj.art-9179ce35d8274560931764febe5d5eed |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-11T01:05:01Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-9179ce35d8274560931764febe5d5eed2022-12-22T01:26:13ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-07-011010.3389/fcell.2022.894305894305Disease-Associated Regulation of Non-Coding RNAs by Resveratrol: Molecular Insights and Therapeutic ApplicationsRoberta Giordo0Zena Wehbe1Anna Maria Posadino2Gian Luca Erre3Ali H. Eid4Arduino A. Mangoni5Arduino A. Mangoni6Gianfranco Pintus7Gianfranco Pintus8College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab EmiratesVascular Biology Research Centre, Molecular and Clinical Research Institute, University of London, London, United KingdomDepartment of Biomedical Sciences, University of Sassari, Sassari, ItalyRheumatology Unit, Department of Clinical and Experimental Medicine, University Hospital (AOUSS) and University of Sassari, Sassari, ItalyDepartment of Basic Medical Sciences, College of Medicine, Q.U. Health. Qatar University, Doha, QatarDiscipline of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Adelaide, SA, AustraliaDepartment of Clinical Pharmacology, Flinders Medical Centre, Adelaide, SA, AustraliaDepartment of Biomedical Sciences, University of Sassari, Sassari, ItalyDepartment of Medical Laboratory Sciences, College of Health Sciences and Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab EmiratesThere have been significant advances, particularly over the last 20 years, in the identification of non-coding RNAs (ncRNAs) and their pathophysiological role in a wide range of disease states, particularly cancer and other chronic conditions characterized by excess inflammation and oxidative stress such as atherosclerosis, diabetes, obesity, multiple sclerosis, osteoporosis, liver and lung fibrosis. Such discoveries have potential therapeutic implications as a better understanding of the molecular mechanisms underpinning the effects of ncRNAs on critical homeostatic control mechanisms and biochemical pathways might lead to the identification of novel druggable targets. In this context, increasing evidence suggests that several natural compounds can target ncRNAs at different levels and, consequently, influence processes involved in the onset and progression of disease states. The natural phenol resveratrol has been extensively studied for therapeutic purposes in view of its established anti-inflammatory and antioxidant effects, particularly in disease states such as cancer and cardiovascular disease that are associated with human aging. However, increasing in vitro and in vivo evidence also suggests that resveratrol can directly target various ncRNAs and that this mediates, at least in part, its potential therapeutic effects. This review critically appraises the available evidence regarding the resveratrol-mediated modulation of different ncRNAs in a wide range of disease states characterized by a pro-inflammatory state and oxidative stress, the potential therapeutic applications, and future research directions.https://www.frontiersin.org/articles/10.3389/fcell.2022.894305/fullnon-coding RNAsncRNAsresveratrolatherosclerosisdiabetesobesity |
| spellingShingle | Roberta Giordo Zena Wehbe Anna Maria Posadino Gian Luca Erre Ali H. Eid Arduino A. Mangoni Arduino A. Mangoni Gianfranco Pintus Gianfranco Pintus Disease-Associated Regulation of Non-Coding RNAs by Resveratrol: Molecular Insights and Therapeutic Applications Frontiers in Cell and Developmental Biology non-coding RNAs ncRNAs resveratrol atherosclerosis diabetes obesity |
| title | Disease-Associated Regulation of Non-Coding RNAs by Resveratrol: Molecular Insights and Therapeutic Applications |
| title_full | Disease-Associated Regulation of Non-Coding RNAs by Resveratrol: Molecular Insights and Therapeutic Applications |
| title_fullStr | Disease-Associated Regulation of Non-Coding RNAs by Resveratrol: Molecular Insights and Therapeutic Applications |
| title_full_unstemmed | Disease-Associated Regulation of Non-Coding RNAs by Resveratrol: Molecular Insights and Therapeutic Applications |
| title_short | Disease-Associated Regulation of Non-Coding RNAs by Resveratrol: Molecular Insights and Therapeutic Applications |
| title_sort | disease associated regulation of non coding rnas by resveratrol molecular insights and therapeutic applications |
| topic | non-coding RNAs ncRNAs resveratrol atherosclerosis diabetes obesity |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.894305/full |
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