Association between the triglyceride glucose index and diabetic retinopathy in type 2 diabetes: a meta-analysis
The triglyceride-glucose (TyG) index is an accessible and reliable surrogate indicator of insulin resistance and is strongly associated with diabetes. However, its relationship with diabetic retinopathy (DR) remains controversial. This meta-analysis aimed to assess the relationship between the TyG i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1302127/full |
| _version_ | 1797401427890405376 |
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| author | Jianlong Zhou Lv Zhu Yadi Li |
| author_facet | Jianlong Zhou Lv Zhu Yadi Li |
| author_sort | Jianlong Zhou |
| collection | DOAJ |
| description | The triglyceride-glucose (TyG) index is an accessible and reliable surrogate indicator of insulin resistance and is strongly associated with diabetes. However, its relationship with diabetic retinopathy (DR) remains controversial. This meta-analysis aimed to assess the relationship between the TyG index and the prevalence of DR. Initial studies were searched from PubMed, Embase, Web of Science, and China National Knowledge Infrastructure (CNKI) electronic databases. The retrieval time range was from the establishment of the database to June 2023. Pooled estimates were derived using a random-effects model and reported as odds ratio (OR) with 95% confidence intervals (CIs). Two researchers independently assessed the methodological quality of the included studies. The Newcastle-Ottawa Quality Scale (NOS) was utilized to assess cohort studies or case-control studies. The Agency for Healthcare Research and Quality (AHRQ) methodology checklist was applied to assess cross-sectional studies. Ten observational studies encompassing 13716 patients with type 2 diabetes were included in the meta-analysis. The results showed that a higher TyG index increased the risk of DR compared with a low TyG index (OR: 2.34, 95% CI: 1.31-4.19, P < 0.05). When the index was analyzed as a continuous variable, consistent results were observed (OR: 1.48, 95% CI: 1.12-1.97, P < 0.005). There was no significant effect on the results of the sensitivity analyses excluding one study at a time (P all < 0.05). A higher TyG index may be associated with an increased prevalence of DR in patients with type 2 diabetes. However, high-quality cohort or case-control studies are needed to further substantiate this evidence.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023432747. |
| first_indexed | 2024-03-09T02:09:56Z |
| format | Article |
| id | doaj.art-9179e5b8a6f14edbb0bc9d1945e31f59 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-09T02:09:56Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-9179e5b8a6f14edbb0bc9d1945e31f592023-12-07T14:39:57ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-12-011410.3389/fendo.2023.13021271302127Association between the triglyceride glucose index and diabetic retinopathy in type 2 diabetes: a meta-analysisJianlong Zhou0Lv Zhu1Yadi Li2Department of Traditional Chinese Medicine, People’s Hospital of Deyang City, Deyang, ChinaDepartment of Integrative Medicine, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Traditional Chinese Medicine, People’s Hospital of Deyang City, Deyang, ChinaThe triglyceride-glucose (TyG) index is an accessible and reliable surrogate indicator of insulin resistance and is strongly associated with diabetes. However, its relationship with diabetic retinopathy (DR) remains controversial. This meta-analysis aimed to assess the relationship between the TyG index and the prevalence of DR. Initial studies were searched from PubMed, Embase, Web of Science, and China National Knowledge Infrastructure (CNKI) electronic databases. The retrieval time range was from the establishment of the database to June 2023. Pooled estimates were derived using a random-effects model and reported as odds ratio (OR) with 95% confidence intervals (CIs). Two researchers independently assessed the methodological quality of the included studies. The Newcastle-Ottawa Quality Scale (NOS) was utilized to assess cohort studies or case-control studies. The Agency for Healthcare Research and Quality (AHRQ) methodology checklist was applied to assess cross-sectional studies. Ten observational studies encompassing 13716 patients with type 2 diabetes were included in the meta-analysis. The results showed that a higher TyG index increased the risk of DR compared with a low TyG index (OR: 2.34, 95% CI: 1.31-4.19, P < 0.05). When the index was analyzed as a continuous variable, consistent results were observed (OR: 1.48, 95% CI: 1.12-1.97, P < 0.005). There was no significant effect on the results of the sensitivity analyses excluding one study at a time (P all < 0.05). A higher TyG index may be associated with an increased prevalence of DR in patients with type 2 diabetes. However, high-quality cohort or case-control studies are needed to further substantiate this evidence.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023432747.https://www.frontiersin.org/articles/10.3389/fendo.2023.1302127/fulltriglyceride glucose indexdiabetic retinopathytype 2 diabetesmeta-analysisobservational study |
| spellingShingle | Jianlong Zhou Lv Zhu Yadi Li Association between the triglyceride glucose index and diabetic retinopathy in type 2 diabetes: a meta-analysis Frontiers in Endocrinology triglyceride glucose index diabetic retinopathy type 2 diabetes meta-analysis observational study |
| title | Association between the triglyceride glucose index and diabetic retinopathy in type 2 diabetes: a meta-analysis |
| title_full | Association between the triglyceride glucose index and diabetic retinopathy in type 2 diabetes: a meta-analysis |
| title_fullStr | Association between the triglyceride glucose index and diabetic retinopathy in type 2 diabetes: a meta-analysis |
| title_full_unstemmed | Association between the triglyceride glucose index and diabetic retinopathy in type 2 diabetes: a meta-analysis |
| title_short | Association between the triglyceride glucose index and diabetic retinopathy in type 2 diabetes: a meta-analysis |
| title_sort | association between the triglyceride glucose index and diabetic retinopathy in type 2 diabetes a meta analysis |
| topic | triglyceride glucose index diabetic retinopathy type 2 diabetes meta-analysis observational study |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1302127/full |
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