Elimination of Extracellular Adenosine Triphosphate for the Rapid Prediction of Quantitative Plate Counts in 24 h Time-Kill Studies against Carbapenem-Resistant Gram-Negative Bacteria

Elimination of Extracellular Adenosine Triphosphate for the Rapid Prediction of Quantitative Plate Counts in 24 h Time-Kill Studies against Carbapenem-Resistant Gram-Negative Bacteria

Traditional in vitro time-kill studies (TKSs) require viable plating, which is tedious and time-consuming. We used ATP bioluminescence, with the removal of extracellular ATP (EC-ATP), as a surrogate for viable plating in TKSs against carbapenem-resistant Gram-negative bacteria (CR-GNB). Twenty-four-...

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Bibliographic Details
Main Authors: Yiying Cai, Jonathan J. Ng, Hui Leck, Jocelyn Q. Teo, Jia-Xuan Goh, Winnie Lee, Tse-Hsien Koh, Thuan-Tong Tan, Tze-Peng Lim, Andrea L. Kwa
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Microorganisms
Subjects:
time-kill studies
ATP bioluminescence
apyrase
Online Access:https://www.mdpi.com/2076-2607/8/10/1489

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