Risk Factors in Predicting Prognosis of Neonatal Bacterial Meningitis—A Systematic Review
Background: Neonatal bacterial meningitis is a severe infection with high mortality and morbidity. It is necessary to identify factors associated with a high risk of a poor prognosis so that we can prevent them with more appropriate treatments. This study was performed to summarize the prognostic fa...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-11-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2018.00929/full |
| _version_ | 1828387709223174144 |
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| author | Dan-Hua Mao Jing-Kun Miao Xian Zou Na Chen Lin-Chao Yu Xin Lai Meng-Yuan Qiao Qi-Xiong Chen Qi-Xiong Chen |
| author_facet | Dan-Hua Mao Jing-Kun Miao Xian Zou Na Chen Lin-Chao Yu Xin Lai Meng-Yuan Qiao Qi-Xiong Chen Qi-Xiong Chen |
| author_sort | Dan-Hua Mao |
| collection | DOAJ |
| description | Background: Neonatal bacterial meningitis is a severe infection with high mortality and morbidity. It is necessary to identify factors associated with a high risk of a poor prognosis so that we can prevent them with more appropriate treatments. This study was performed to summarize the prognostic factors known to predict adverse outcomes in neonatal bacterial meningitis.Methods: The Medline/PubMed, Cochrane Library and Embase databases were searched for studies of prognostic risk factors in neonates with bacterial meningitis. Studies published from the initiation of the database to April 30th, 2017 were included. The quality of cohort studies was assessed by the Newcastle-Ottawa Scale (NOS). The quality of cross-section studies was assessed by the Agency for Healthcare Research and Quality (AHRQ) scale. Each prognostic factor known to cause adverse outcomes is summarized.Results: Sixteen studies were identified, including 7 cohort studies and 9 cross section studies. Seizure and high protein levels in the cerebrospinal fluid (CSF) predict a poor prognosis in this disease. Coma, the need for ventilation support, and leukopenia also had some value for predicting poor prognoses. A bulging anterior fontanelle was valuable for predicting mortality. Low CSF glucose levels, thrombocytopenia, gestational age (GA) < 37 weeks and an altered sensorium were correlated with a poor prognosis. A birth weight < 2500 g, early onset meningitis and positive CSF cultures were correlated with mortality.Conclusions: This study provides a preliminary exploration of prognostic factors in neonatal bacterial meningitis and thereby fills some of the gaps in the study of prognoses in this disease. These prognostic factors can be used to predict and estimate outcomes in neonatal bacterial meningitis. Without a meta-analysis, the reliability of these factors cannot be assured. In addition, these results emphasize that there is an urgent need for a standardized protocol for follow-up and well-designed prognostic studies in neonatal bacterial meningitis. |
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| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-10T05:59:41Z |
| publishDate | 2018-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-917ce61469d74584a725f8869e34049b2022-12-22T01:59:51ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-11-01910.3389/fneur.2018.00929410210Risk Factors in Predicting Prognosis of Neonatal Bacterial Meningitis—A Systematic ReviewDan-Hua Mao0Jing-Kun Miao1Xian Zou2Na Chen3Lin-Chao Yu4Xin Lai5Meng-Yuan Qiao6Qi-Xiong Chen7Qi-Xiong Chen8Department of Neonatology, Children's Hospital, Chongqing Medical University, Chongqing, ChinaChongqing International Science and Technology Cooperation base of Child Development and Critical Disorders, Chongqing, ChinaChongqing International Science and Technology Cooperation base of Child Development and Critical Disorders, Chongqing, ChinaMinistry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaMinistry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaChongqing Key Laboratory of Pediatrics, Chongqing, ChinaChongqing Key Laboratory of Pediatrics, Chongqing, ChinaDepartment of Neonatology, Children's Hospital, Chongqing Medical University, Chongqing, ChinaChongqing Traditional Chinese Medicine Hospital, Chongqing, ChinaBackground: Neonatal bacterial meningitis is a severe infection with high mortality and morbidity. It is necessary to identify factors associated with a high risk of a poor prognosis so that we can prevent them with more appropriate treatments. This study was performed to summarize the prognostic factors known to predict adverse outcomes in neonatal bacterial meningitis.Methods: The Medline/PubMed, Cochrane Library and Embase databases were searched for studies of prognostic risk factors in neonates with bacterial meningitis. Studies published from the initiation of the database to April 30th, 2017 were included. The quality of cohort studies was assessed by the Newcastle-Ottawa Scale (NOS). The quality of cross-section studies was assessed by the Agency for Healthcare Research and Quality (AHRQ) scale. Each prognostic factor known to cause adverse outcomes is summarized.Results: Sixteen studies were identified, including 7 cohort studies and 9 cross section studies. Seizure and high protein levels in the cerebrospinal fluid (CSF) predict a poor prognosis in this disease. Coma, the need for ventilation support, and leukopenia also had some value for predicting poor prognoses. A bulging anterior fontanelle was valuable for predicting mortality. Low CSF glucose levels, thrombocytopenia, gestational age (GA) < 37 weeks and an altered sensorium were correlated with a poor prognosis. A birth weight < 2500 g, early onset meningitis and positive CSF cultures were correlated with mortality.Conclusions: This study provides a preliminary exploration of prognostic factors in neonatal bacterial meningitis and thereby fills some of the gaps in the study of prognoses in this disease. These prognostic factors can be used to predict and estimate outcomes in neonatal bacterial meningitis. Without a meta-analysis, the reliability of these factors cannot be assured. In addition, these results emphasize that there is an urgent need for a standardized protocol for follow-up and well-designed prognostic studies in neonatal bacterial meningitis.https://www.frontiersin.org/article/10.3389/fneur.2018.00929/fullneonatebacterial meningitisprognostic factorsrisk factorssystematic review |
| spellingShingle | Dan-Hua Mao Jing-Kun Miao Xian Zou Na Chen Lin-Chao Yu Xin Lai Meng-Yuan Qiao Qi-Xiong Chen Qi-Xiong Chen Risk Factors in Predicting Prognosis of Neonatal Bacterial Meningitis—A Systematic Review Frontiers in Neurology neonate bacterial meningitis prognostic factors risk factors systematic review |
| title | Risk Factors in Predicting Prognosis of Neonatal Bacterial Meningitis—A Systematic Review |
| title_full | Risk Factors in Predicting Prognosis of Neonatal Bacterial Meningitis—A Systematic Review |
| title_fullStr | Risk Factors in Predicting Prognosis of Neonatal Bacterial Meningitis—A Systematic Review |
| title_full_unstemmed | Risk Factors in Predicting Prognosis of Neonatal Bacterial Meningitis—A Systematic Review |
| title_short | Risk Factors in Predicting Prognosis of Neonatal Bacterial Meningitis—A Systematic Review |
| title_sort | risk factors in predicting prognosis of neonatal bacterial meningitis a systematic review |
| topic | neonate bacterial meningitis prognostic factors risk factors systematic review |
| url | https://www.frontiersin.org/article/10.3389/fneur.2018.00929/full |
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