Associations between air pollutants and acute exacerbation of drug-resistant tuberculosis: evidence from a prospective cohort study
Abstract Background Short-term exposure to air pollution may trigger symptoms of drug-resistant tuberculosis (DR-TB) through stimulating lung tissue, damaging tracheobronchial mucosa, the key anti-mycobacterium T cell immune function, and production and release of inflammatory cytokines. Objective T...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-024-09011-x |
| _version_ | 1797276691110821888 |
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| author | Chan-Na Zhao Zhiwei Xu Peng Wang Jie Liu Rong Wang Hai-Feng Pan Fangjin Bao |
| author_facet | Chan-Na Zhao Zhiwei Xu Peng Wang Jie Liu Rong Wang Hai-Feng Pan Fangjin Bao |
| author_sort | Chan-Na Zhao |
| collection | DOAJ |
| description | Abstract Background Short-term exposure to air pollution may trigger symptoms of drug-resistant tuberculosis (DR-TB) through stimulating lung tissue, damaging tracheobronchial mucosa, the key anti-mycobacterium T cell immune function, and production and release of inflammatory cytokines. Objective To investigate the association between acute exacerbations of DR-TB and short-term residential exposure to air pollutants (PM10, PM2.5, SO2, NO2, CO and O3) based on a large prospective cohort in Anhui Province, China. Method Patients were derived from a prospective cohort study of DR-TB in Anhui Province. All DR-TB patients underwent drug-susceptibility testing and prefecture-level reference laboratories confirmed their microbiologies. The case-crossover design was performed to evaluate the association between the risk of acute exacerbations of DR-TB and short-term residential exposure to air pollution. Results Short-term NO2 exposure was significantly related to an elevated risk of first-time outpatient visit due to acute exacerbations of DR-TB(relative risk:1.159, 95% confidence interval:1.011 ~ 1.329). Stratification analyses revealed that the relationship between the risk of acute exacerbations and NO2 exposure was stronger in the elderly (age ≥ 65) DR-TB patients, and in individuals with a history of TB treatment. Conclusions NO2 Exposure was significantly associated with an elevated risk of acute exacerbation of DR-TB in Anhui Province, China. |
| first_indexed | 2024-03-07T15:32:51Z |
| format | Article |
| id | doaj.art-917d8e813ac847aa909b4b2c1e2d9732 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-03-07T15:32:51Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-917d8e813ac847aa909b4b2c1e2d97322024-03-05T16:21:17ZengBMCBMC Infectious Diseases1471-23342024-01-012411910.1186/s12879-024-09011-xAssociations between air pollutants and acute exacerbation of drug-resistant tuberculosis: evidence from a prospective cohort studyChan-Na Zhao0Zhiwei Xu1Peng Wang2Jie Liu3Rong Wang4Hai-Feng Pan5Fangjin Bao6Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical UniversitySchool of Medicine and Dentistry, Griffith UniversityTeaching Center for Preventive Medicine, School of Public Health, Anhui Medical UniversityDepartment of Tuberculosis Control, Tuberculosis Control Institute of Anhui ProvinceDepartment of Tuberculosis Control, Tuberculosis Control Institute of Anhui ProvinceDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical UniversityDepartment of Tuberculosis Control, Tuberculosis Control Institute of Anhui ProvinceAbstract Background Short-term exposure to air pollution may trigger symptoms of drug-resistant tuberculosis (DR-TB) through stimulating lung tissue, damaging tracheobronchial mucosa, the key anti-mycobacterium T cell immune function, and production and release of inflammatory cytokines. Objective To investigate the association between acute exacerbations of DR-TB and short-term residential exposure to air pollutants (PM10, PM2.5, SO2, NO2, CO and O3) based on a large prospective cohort in Anhui Province, China. Method Patients were derived from a prospective cohort study of DR-TB in Anhui Province. All DR-TB patients underwent drug-susceptibility testing and prefecture-level reference laboratories confirmed their microbiologies. The case-crossover design was performed to evaluate the association between the risk of acute exacerbations of DR-TB and short-term residential exposure to air pollution. Results Short-term NO2 exposure was significantly related to an elevated risk of first-time outpatient visit due to acute exacerbations of DR-TB(relative risk:1.159, 95% confidence interval:1.011 ~ 1.329). Stratification analyses revealed that the relationship between the risk of acute exacerbations and NO2 exposure was stronger in the elderly (age ≥ 65) DR-TB patients, and in individuals with a history of TB treatment. Conclusions NO2 Exposure was significantly associated with an elevated risk of acute exacerbation of DR-TB in Anhui Province, China.https://doi.org/10.1186/s12879-024-09011-xAir pollutantsDrug-resistant tuberculosisNO2 |
| spellingShingle | Chan-Na Zhao Zhiwei Xu Peng Wang Jie Liu Rong Wang Hai-Feng Pan Fangjin Bao Associations between air pollutants and acute exacerbation of drug-resistant tuberculosis: evidence from a prospective cohort study BMC Infectious Diseases Air pollutants Drug-resistant tuberculosis NO2 |
| title | Associations between air pollutants and acute exacerbation of drug-resistant tuberculosis: evidence from a prospective cohort study |
| title_full | Associations between air pollutants and acute exacerbation of drug-resistant tuberculosis: evidence from a prospective cohort study |
| title_fullStr | Associations between air pollutants and acute exacerbation of drug-resistant tuberculosis: evidence from a prospective cohort study |
| title_full_unstemmed | Associations between air pollutants and acute exacerbation of drug-resistant tuberculosis: evidence from a prospective cohort study |
| title_short | Associations between air pollutants and acute exacerbation of drug-resistant tuberculosis: evidence from a prospective cohort study |
| title_sort | associations between air pollutants and acute exacerbation of drug resistant tuberculosis evidence from a prospective cohort study |
| topic | Air pollutants Drug-resistant tuberculosis NO2 |
| url | https://doi.org/10.1186/s12879-024-09011-x |
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