Subjects suffering from bipolar disorder taking lithium are less likely to report physical pain: a FACE-BD study
Abstract Background Physical pain is a common issue in people with bipolar disorder (BD). It worsens mental health and quality of life, negatively impacts treatment response, and increases the risk of suicide. Lithium, which is prescribed in BD as a mood stabilizer, has shown promising effects on...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2024-01-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933823024768/type/journal_article |
| _version_ | 1827378611691192320 |
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| author | Nathan Risch Jonathan Dubois Bruno Etain Bruno Aouizerate Frank Bellivier Raoul Belzeaux Caroline Dubertret Emmanuel Haffen Dominique Januel Marion Leboyer Antoine Lefrere Ludovic Samalin Mircea Polosan Romain Rey Paul Roux Raymund Schwan Michel Walter FondaMental Advanced Centres of Expertise in Bipolar Disorders (FACE-BD) Collaborators Philippe Courtet Emilie Olié |
| author_facet | Nathan Risch Jonathan Dubois Bruno Etain Bruno Aouizerate Frank Bellivier Raoul Belzeaux Caroline Dubertret Emmanuel Haffen Dominique Januel Marion Leboyer Antoine Lefrere Ludovic Samalin Mircea Polosan Romain Rey Paul Roux Raymund Schwan Michel Walter FondaMental Advanced Centres of Expertise in Bipolar Disorders (FACE-BD) Collaborators Philippe Courtet Emilie Olié |
| author_sort | Nathan Risch |
| collection | DOAJ |
| description |
Abstract
Background
Physical pain is a common issue in people with bipolar disorder (BD). It worsens mental health and quality of life, negatively impacts treatment response, and increases the risk of suicide. Lithium, which is prescribed in BD as a mood stabilizer, has shown promising effects on pain.
Methods
This naturalistic study included 760 subjects with BD ( FACE-BD cohort) divided in two groups: with and without self-reported pain (evaluated with the EQ-5D-5L questionnaire). In this sample, 176 subjects were treated with lithium salts. The objectives of the study were to determine whether patients receiving lithium reported less pain, and whether this effect was associated with the recommended mood-stabilizing blood concentration of lithium.
Results
Subjects with lithium intake were less likely to report pain (odds ratio [OR] = 0.59, 95% confidence interval [CI], 0.35–0.95; p = 0.036) after controlling for sociodemographic variables, BD type, lifetime history of psychiatric disorders, suicide attempt, personality traits, current depression and anxiety levels, sleep quality, and psychomotor activity. Subjects taking lithium were even less likely to report pain when lithium concentration in blood was ≥0.5 mmol/l (OR = 0.45, 95% CI, 0.24–0.79; p = 0.008).
Conclusions
This is the first naturalistic study to show lithium’s promising effect on pain in subjects suffering from BD after controlling for many confounding variables. This analgesic effect seems independent of BD severity and comorbid conditions. Randomized controlled trials are needed to confirm the analgesic effect of lithium salts and to determine whether lithium decreases pain in other vulnerable populations.
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| first_indexed | 2024-03-08T12:58:19Z |
| format | Article |
| id | doaj.art-917ea1ebda7145a88931075a7a5c57bd |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-08T12:58:19Z |
| publishDate | 2024-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-917ea1ebda7145a88931075a7a5c57bd2024-01-19T13:16:13ZengCambridge University PressEuropean Psychiatry0924-93381778-35852024-01-016710.1192/j.eurpsy.2023.2476Subjects suffering from bipolar disorder taking lithium are less likely to report physical pain: a FACE-BD studyNathan Risch0https://orcid.org/0000-0002-9632-6077Jonathan Dubois1https://orcid.org/0000-0002-1656-499XBruno Etain2https://orcid.org/0000-0002-5377-1488Bruno Aouizerate3https://orcid.org/0000-0002-7092-7747Frank Bellivier4Raoul Belzeaux5Caroline Dubertret6Emmanuel Haffen7https://orcid.org/0000-0002-4091-518XDominique Januel8Marion Leboyer9Antoine Lefrere10Ludovic Samalin11https://orcid.org/0000-0003-0740-4019Mircea Polosan12Romain Rey13Paul Roux14https://orcid.org/0000-0003-0321-4189Raymund Schwan15Michel Walter16https://orcid.org/0000-0002-3071-7673FondaMental Advanced Centres of Expertise in Bipolar Disorders (FACE-BD) CollaboratorsPhilippe Courtet17https://orcid.org/0000-0002-6519-8586Emilie Olié18Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, Montpellier, France Department of Emergency Psychiatry and Post-Acute Care, CHU Montpellier, Montpellier, France Clinique de la Lironde, Clinea Psychiatrie, Saint-Clément-de-Rivière, FranceInstitute of Functional Genomics, University of Montpellier, CNRS, INSERM, Montpellier, France Department of Emergency Psychiatry and Post-Acute Care, CHU Montpellier, Montpellier, FranceFondation FondaMental, Créteil, France Département de Psychiatrie et de Médecine Addictologique, AP-HP, Groupe Hospitalo-Universitaire AP-HP Nord, DMU Neurosciences, Hôpital Fernand Widal, Paris, France Optimisation Thérapeutique en Neuropsychopharmacologie OTeN, Université Paris Cité, INSERM UMR-S 1144, Paris, FranceFondation FondaMental, Créteil, France Centre Hospitalier Charles Perrens, Bordeaux, France Laboratoire NutriNeuro (UMR INRA 1286), Université de Bordeaux, Bordeaux, FranceFondation FondaMental, Créteil, France Département de Psychiatrie et de Médecine Addictologique, AP-HP, Groupe Hospitalo-Universitaire AP-HP Nord, DMU Neurosciences, Hôpital Fernand Widal, Paris, France Optimisation Thérapeutique en Neuropsychopharmacologie OTeN, Université Paris Cité, INSERM UMR-S 1144, Paris, FranceFondation FondaMental, Créteil, France Pôle Universitaire de Psychiatrie, CHU de Montpellier, Montpellier, France /INT-UMR7289, CNRS Aix-Marseille Université, FranceFondation FondaMental, Créteil, France AP-HP, Groupe Hospitalo-Universitaire AP-HP Nord, DMU ESPRIT, Service de Psychiatrie et Addictologie, Hôpital Louis Mourier, Colombes, France Université de Paris, Inserm UMR1266, Sorbonne Paris Cité, Faculté de Médecine, Paris, FranceFondation FondaMental, Créteil, France Service de Psychiatrie de l’Adulte, CIC-1431 INSERM, CHU de Besançon, Laboratoire de Neurosciences, UFC, UBFC, Besançon, FranceFondation FondaMental, Créteil, France Pôle universitaire 93G03 EPS ville Evrard, Neuilly-sur- Marne, France Université Sorbonne Paris Nord, Bobigny, FranceFondation FondaMental, Créteil, France Translational NeuroPsychiatry Laboratory, Univ Paris Est Créteil, INSERM U955, IMRB, Créteil, France AP-HP, Hôpitaux Universitaires Henri Mondor, Département Médico-Universitaire de Psychiatrie et d’Addictologie (DMU IMPACT), Fédération Hospitalo-Universitaire de Médecine de Précision en Psychiatrie (FHU ADAPT), Créteil, FranceFondation FondaMental, Créteil, France Assistance Publique Hôpitaux de Marseille, Pôle de Psychiatrie, Marseille, France Institut de neurosciences de la Timone UMR 7289, Aix-Marseille Université & CNRS, Marseille, FranceFondation FondaMental, Créteil, France University of Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut Pascal, CHU Clermont-Ferrand, Department of Psychiatry, Clermont-Ferrand, FranceFondation FondaMental, Créteil, France Univ. Grenoble Alpes, Inserm, U1216, CHU Grenoble Alpes, Grenoble Institut Neurosciences, Grenoble, FranceFondation FondaMental, Créteil, France Centre Hospitalier Le Vinatier, INSERM U1028, CNRS UMR5292, Université Claude Bernard Lyon 1, Centre de Recherche en Neurosciences de Lyon, Equipe PSYR2, Pole Est, 95 bd Pinel, BP 30039, Bron Cedex, FranceFondation FondaMental, Créteil, France Centre Hospitalier de Versailles, Service Universitaire de Psychiatrie d’Adultes et d’Addictologie, Le Chesnay, Université Paris-Saclay; Université de Versailles Saint-Quentin-En-Yvelines; DisAP-DevPsy-CESP, INSERM UMR1018, Villejuif, FranceFondation FondaMental, Créteil, France Centre Psychothérapique de Nancy, Inserm, Université de Lorraine, Nancy, FranceFondation FondaMental, Créteil, France Service Hospitalo-Universitaire de Psychiatrie Générale et de Réhabilitation Psycho Sociale 29G01 et 29G02, CHRU de Brest, Hôpital de Bohars, Brest, FranceInstitute of Functional Genomics, University of Montpellier, CNRS, INSERM, Montpellier, France Department of Emergency Psychiatry and Post-Acute Care, CHU Montpellier, Montpellier, France Fondation FondaMental, Créteil, FranceInstitute of Functional Genomics, University of Montpellier, CNRS, INSERM, Montpellier, France Department of Emergency Psychiatry and Post-Acute Care, CHU Montpellier, Montpellier, France Fondation FondaMental, Créteil, France Abstract Background Physical pain is a common issue in people with bipolar disorder (BD). It worsens mental health and quality of life, negatively impacts treatment response, and increases the risk of suicide. Lithium, which is prescribed in BD as a mood stabilizer, has shown promising effects on pain. Methods This naturalistic study included 760 subjects with BD ( FACE-BD cohort) divided in two groups: with and without self-reported pain (evaluated with the EQ-5D-5L questionnaire). In this sample, 176 subjects were treated with lithium salts. The objectives of the study were to determine whether patients receiving lithium reported less pain, and whether this effect was associated with the recommended mood-stabilizing blood concentration of lithium. Results Subjects with lithium intake were less likely to report pain (odds ratio [OR] = 0.59, 95% confidence interval [CI], 0.35–0.95; p = 0.036) after controlling for sociodemographic variables, BD type, lifetime history of psychiatric disorders, suicide attempt, personality traits, current depression and anxiety levels, sleep quality, and psychomotor activity. Subjects taking lithium were even less likely to report pain when lithium concentration in blood was ≥0.5 mmol/l (OR = 0.45, 95% CI, 0.24–0.79; p = 0.008). Conclusions This is the first naturalistic study to show lithium’s promising effect on pain in subjects suffering from BD after controlling for many confounding variables. This analgesic effect seems independent of BD severity and comorbid conditions. Randomized controlled trials are needed to confirm the analgesic effect of lithium salts and to determine whether lithium decreases pain in other vulnerable populations. https://www.cambridge.org/core/product/identifier/S0924933823024768/type/journal_articlebipolar disorderlithiumlithium plasma levelmood disorderspain |
| spellingShingle | Nathan Risch Jonathan Dubois Bruno Etain Bruno Aouizerate Frank Bellivier Raoul Belzeaux Caroline Dubertret Emmanuel Haffen Dominique Januel Marion Leboyer Antoine Lefrere Ludovic Samalin Mircea Polosan Romain Rey Paul Roux Raymund Schwan Michel Walter FondaMental Advanced Centres of Expertise in Bipolar Disorders (FACE-BD) Collaborators Philippe Courtet Emilie Olié Subjects suffering from bipolar disorder taking lithium are less likely to report physical pain: a FACE-BD study European Psychiatry bipolar disorder lithium lithium plasma level mood disorders pain |
| title | Subjects suffering from bipolar disorder taking lithium are less likely to report physical pain: a FACE-BD study |
| title_full | Subjects suffering from bipolar disorder taking lithium are less likely to report physical pain: a FACE-BD study |
| title_fullStr | Subjects suffering from bipolar disorder taking lithium are less likely to report physical pain: a FACE-BD study |
| title_full_unstemmed | Subjects suffering from bipolar disorder taking lithium are less likely to report physical pain: a FACE-BD study |
| title_short | Subjects suffering from bipolar disorder taking lithium are less likely to report physical pain: a FACE-BD study |
| title_sort | subjects suffering from bipolar disorder taking lithium are less likely to report physical pain a face bd study |
| topic | bipolar disorder lithium lithium plasma level mood disorders pain |
| url | https://www.cambridge.org/core/product/identifier/S0924933823024768/type/journal_article |
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